This paper examines the complex political-economic processes that shape contemporary forced displacement from Guatemala to the U.S. The study was driven by the following research question: How does capitalism and the historical context of forced migration in Guatemala relate to the creation and development of migrant-led organizations in the U.S. and the various types of leadership and political participation? Examining the political economy of Guatemalan migration to the Greater Los Angeles region and the activities of migrants and community organizations, I argue that neoliberal capitalism not only provokes the displacement of Guatemalan migrants as a social class of people from multiple racial and ethnic backgrounds, but it has also contributed to the emergence of distinct political Guatemalan diaspora organizations in the U.S. at the community, national, and transnational level. Furthermore, due to historical social relations in Guatemala, organizations have emerged in Southern California along ethnic, racial, and gender lines. Moreover, activism emerges within destination countries because exploitation and exclusion take on distinct forms beyond the specific economic and political forces that generate displacement in migrants’ origin countries. As such, these organizations have made significant contributions by safeguarding the human rights of Guatemalan migrants in the U.S. and have emerged based on the differences and inequalities faced by indigenous communities compared to non-indigenous (mestizo/ladino) groups as they and their organizations endure processes of “exclusionary inclusion” in the U.S.