Abstract: By 2001, two years after approval, the new MassGeneral Institute for Neurodegenerative Disease (MIND) building was designed, built and opened. About 30 independent faculty laboratory heads occupied the laboratory floors. Each lab head had 5–15 people in their lab and in total about 300 people worked on the two main floors. Anne’s lab and office moved to MIND. Early on, she was still very depressed about Jack’s death and needed help to continue her research. Without Jack, Anne didn’t have enthusiasm or ambition. Zane Hollingsworth and Anne’s previous trainees, Jang-Ho Cha and David Standaert, helped Anne with her students, postdocs, technicians and grants. Anne was elected president of the American Neurological Association and then president of the Society for Neuroscience. Six years after Jack died, Anne received an email from her old eighth-grade and sometimes high school boyfriend, Stetson Ames. He was coming to Boston in May and asked Anne if she would like to meet. She and Stets eventually married. Anne inherited $2 million when her mother died, a million of which she donated to Mass General. Nancy Wexler began showing signs of Huntington’s disease. It was undeniable, but neither Anne nor Nancy could face the devastating possibility.

Abstract: After Jack’s death, it took Anne time to get back into any routine at work. Because she was in a lot of pain, Anne wasn’t on call for patient care for the first year after Jack was gone. She fell into a deep depression from her grief but tried her best to function. Anne’s colleagues and friends such as Beverly Mahfuz, Walter Koroshetz, Jane Holtz, Sherri O’Grady and Rita Zollo (Jack’s secretary) all pitched in. Anne also turned to alcohol to ease her pain. She didn’t recognize that she had a problem with alcohol. Alice Flaherty, Anne’s colleague and trainee, helped her find a psychiatrist. Anne went to work every day and completed all her administrative work. There was a lot to do planning the new building – meeting with the architects and construction crews. Anne’s daughters managed at school despite their grief. Anne held a memorial in honor of Jack at a church. People came from the hospital and laboratory. Friends and family were there. Jack’s patients came. Neurologists from all over the country came. The next day, Anne took the urn of ashes with Jack’s dad, his wife, Jack’s sister and brother and their spouses, Ellen and Jessie, Jang-Ho and his wife and Nancy Serrell up to the graveyard in New Hampshire to say their goodbyes and put notes in the urn.