Scholars, beginning with Hippolyte Delehaye, have long claimed a distinction between eastern and western customs of relic veneration in late antiquity: westerners left martyrial corpses intact and did not translate them, using contact relics instead, while easterners readily moved and divided these relics. They base this distinction on two papal letters from Pope Hormisdas’s legates and from Gregory the Great that distinguish between Roman and Greek customs of relics veneration. Yet scholars have almost totally neglected one piece of late antique evidence highly instructive for this topic: a letter from Eusebios of Thessaloniki, a contemporary of Gregory the Great, responding to a request from the emperor Maurice to send a corporeal relic of the Thessalonian martyr Demetrios. I argue that Eusebios’s letter demonstrates that the distinction between Roman and Greek customs of relic veneration proposed by the papal letters does not hold in late sixth-/early seventh-century Thessaloniki; furthermore, rather than giving evidence for sweeping, regional patterns, these letters all offer reflections on local, municipal customs of relic veneration in Rome and Thessaloniki in response to local imperial customs in Constantinople.