Common milkweed is a creeping perennial weed that is problematic in row crops and pastures. Its ability to readily reproduce via adventitious root buds enables it to persist, and full control often requires several growing seasons of management. Although it is a troublesome agricultural weed, common milkweed is ecologically important due to its use as a food source for many arthropod species. Declines in common milkweed populations in North America have been correlated with and blamed for declines in monarch butterfly populations. This review summarizes available information on the biology, ecology, and management of common milkweed, as well as its potential uses and provisioning of ecosystem services.