Abstract: Anne and Jack researched the effects of dopamine on striatal cells. They worked with graduate student Helen Pan, fellow Roger Albin and colleague Anton Reiner. Anne and Jack were invited to present their theory at a symposium on basal ganglia research in Manchester, UK. In August 1987, the Michigan Chapter of the Committee to Combat Huntington’s Disease hosted the national organization’s annual meeting in Ann Arbor, where Jack and Anne gave talks to the attendees. Nancy stayed at Anne and Jack’s and spent time with Jessie and Ellen. They witnessed an explosion in the sky, which turned out to be a terrible plane crash. When Anne was in London for an Alzheimer’s symposium, Jack had a life-threatening internal bleed from taking 12 aspirin a day. Jack was very stoic and didn’t like to complain about his health. Anne and Jack’s lab became the most popular among MD/PhD students interested in neuroscience. The longer Jack and Anne lived together, the more they became one person. Anne, Roger Albin and Jack put together a manuscript titled, “The Functional Anatomy of Basal Ganglia Disorders” as a speculative review for the journal Trends in Neuroscience, which was published in 1989. The model has stood the test of time and is cited often 35 years after it was published.

Abstract: At Ann Arbor, Anne applied for grants from the National Institutes of Health (NIH) and the National Institute of Neurological Disorders and Stroke, which she received. Sid Gilman suggested Anne speak with her health science administrator (HSA) Nancy Wexler for advice. Wexler told Anne her grant proposal was accepted. With the grants, Anne and Jack could spend 80 percent of their time in the laboratory and 20 percent of their time seeing patients (one day a week). The experiments Anne proposed turned out to be complete failures. She decided that it was not worth pursuing further. Instead, Anne and Jack used their time to study the main pathways of the motor system. Jack did the surgery, made and evaluated the lesions and Anne conducted the biochemical experiments. They proposed the idea of a Movement Disorders Clinic to Sid. They hoped to focus on Parkinson’s disease, Huntington’s disease and related disorders. Movement disorders fascinated both Anne and Jack because it was a subspecialty relying on direct patient observation. With the stability provided by the grants, Anne and Jack decided to have another child, Ellen. Anne met Nancy Wexler at the Society for Neuroscience meeting in Atlanta after Ellen was born.