Christian Connection women – Deborah Peirce, Harriet Livermore, and Rebecca Miller – who penned three of America’s earliest defenses of a woman’s right to preach from 1820 to 1841, conceived of themselves not only as exhorters, evangelists, and preachers but also as interpreters of the Bible. This analysis of their distinctive hermeneutical strategies demonstrates how they interpreted Philippians 4:2–3 as ballast for Christian Connection female laborers to preach and how they exploited the church’s distinction between worship and business meetings to limit Paul’s injunction to silence (1 Corinthians 14:34–35) to business meetings only. It illuminates their distinctive contributions as biblical interpreters by setting their defenses alongside influential commentaries written by men, Sarah Grimké’s defense of women’s preaching (1838), and memoirs authored by early American women preachers. Without the writings of Peirce, Livermore, and Miller, it might be possible to draw an artificial bifurcation in antebellum Christianity between interpretation and experience, that is, between commentaries and Grimké’s Letters, whose primary purpose is to interpret the Bible without explicit reference to experience, and the memoirs of women called to preach, for whom the ascendant attribute of their call was an experience that no text or interpretation could invalidate. These Christian Connection defenses mitigate such a dichotomy.