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INC-5.2 presents a critical opportunity to protect the health of current and future generations

Published online by Cambridge University Press:  04 July 2025

Cressida Bowyer*
Affiliation:
Revolution Plastics Institute, University of Portsmouth , Portsmouth, UK
*
Corresponding author: Cressida Bowyer; Email: cressida.bowyer@port.ac.uk
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Abstract

Plastic pollution poses a critical and escalating threat to human health across the full life cycle of plastics. Scientific evidence links exposure to plastics and associated pollution to a range of adverse health outcomes. Vulnerable populations, particularly those in informal settlements and low-resource settings, bear disproportionate health burdens. The UN Global Plastics Treaty presents a vital opportunity to embed human health protection at its core. To be effective, the treaty must apply the precautionary principle, recognise and address health impacts across the full plastics life cycle, and phase out the most harmful plastic products and chemicals. The treaty must be adaptable to emerging scientific evidence, and inclusive of equity and human rights to protect present and future generations. Inclusion of a dedicated health article, alongside specific health considerations across a number of key provisions in the treaty text, and consideration of the right to health throughout all aspects of the treaty, will be essential for delivering on the treaty’s objective to protect human health and the environment from plastic pollution.

Information

Type
Letter to the Editor
Creative Commons
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and/or adaptation of the article.
Copyright
© The Author(s), 2025. Published by Cambridge University Press

Impact statement

Plastic pollution is a global health emergency. This article summarises some of the scientific evidence linking plastic pollution to human health harms, and demonstrates that plastics pose serious health risks across the full life cycle. The article recommends that the global plastics treaty applies the precautionary principle in order to minimise and prevent human health risks. The article also highlights the unequal burden of health harms from plastic pollution and reminds that a right to health is a fundamental human right. It argues that human health must be considered throughout the treaty and should be explicitly addressed in relevant treaty provisions. The article discusses opportunities to reduce plastic use in the healthcare setting, and outlines the important role of the healthcare sector in shaping and implementing an ambitious and effective treaty.

Introduction

Plastic pollution is a global health crisis. A growing body of evidence demonstrates that plastics and plastic pollution pose serious risks to human health, with a wide range of adverse health impacts occurring across the full life cycle of plastics, from extraction and manufacturing, through to use and disposal (Landrigan et al., Reference Landrigan, Raps, Cropper, Bald, Brunner, Canonizado, Charles, Chiles, Donohue, Enck, Fenichel, Fleming, Ferrier-Pages, Fordham, Gozt, Griffin, Hahn, Haryanto, Hixson, Ianelli, James, Kumar, Laborde, Law, Martin, Mu, Mulders, Mustapha, Niu, Pahl, Park, Pedrotti, Pitt, Ruchirawat, Seewoo, Spring, Stegeman, Suk, Symeonides, Takada, Thompson, Vicini, Wang, Whitman, Wirth, Wolff, Yousuf and Dunlop2023).

At the conclusion of the United Nations Environment Assembly in March 2022, representatives from the Member States of the United Nations agreed on a mandate to create a first-of-its-kind international, legally binding instrument to end plastic pollution. And so began the series of five Intergovernmental Negotiating Committee (INC) meetings to develop the instrument. The urgent need to protect human health from plastic pollution is evident in the current draft treaty text that will form the basis for negotiations at the upcoming INC-5.2 meeting (UNEP, 2024). The Preamble of this draft text states: “Noting with concern that the high and rapidly increasing levels of plastic pollution, including in the marine environment, represent a serious environmental and human health problem, negatively impacting the environmental, social and economic dimensions of sustainable development,” whilst the Objective states: “The objective of this Convention is to protect human health and the environment from plastic pollution, including in the marine environment [based on a comprehensive approach that address the full life cycle of plastics]” (all bolding author’s own). The agreed treaty must therefore be fit for purpose to deliver on this objective.

In order to do so, the treaty must address the human health impacts across the full plastics life cycle. This can be achieved through addressing these impacts in all relevant operative provisions of the treaty text and ensuring that implementation effectively supports and enables achievement of the instrument’s objective.

Do no harm: The precautionary principle and known health impacts of plastics and plastic pollution

The precautionary principle “enables decision-makers to adopt precautionary measures when scientific evidence about an environmental or human health hazard is uncertain and the stakes are high” (EU Parliament Think Tank, 2015). The evidence that plastics harm human health is, in fact, clear. The treaty must be ground truthed in robust science and the precautionary principle.

Plastics and chemicals

We have decades of evidence regarding the environmental and health impacts of chemical additives used in the production of plastics (UNEP, 2023). Chemical additives leach from plastic products when we use and dispose of them, and they are present in our food, soil, air and water (Hahladakis et al., Reference Hahladakis, Velis, Weber, Iacovidou and Purnell2018; Maddela et al., Reference Maddela, Kakarla, Venkateswarlu and Megharaj2023).

Plastic additives with known toxic effects include bisphenols, phthalates, PFAS (per- and polyfluoroalkyl substances) and flame retardants, and these have been linked to health impacts including endocrine disruption, cancers, neurological disorders, infertility and metabolic disorders (Maddela et al., Reference Maddela, Kakarla, Venkateswarlu and Megharaj2023). Concerningly, we know nothing about the risks to human health of more than half of the 16,000+ plastic additives in use today (Wagner et al., Reference Wagner, Monclús, Arp, Groh, Løseth, Muncke, Wang, Wolf and Zimmermann2024).

It is not only plastic additives that pose a chemical threat. We also know that plastic fragments, microplastics and nanoplastics can act as carriers for other environmental pollutants, adsorbing organic and inorganic compounds from the environment and carrying them into our bodies (Okoye et al., Reference Okoye, Addey, Oderinde, Okoro, Uwamungu, Ikechukwu, Okeke, Ejeromedoghene and Odii2022).

Plastics and disease transmission

The microbiology of plastics, and its impacts thereof, is another cause for concern. This is a relatively new field of study, but research suggests that plastics can become breeding grounds for disease-causing microorganisms, increasing the risk of cholera; this risk is increased where plastic pollution blocks waterways and drains, worsening flooding and spreading waterborne pathogens (Ormsby et al., Reference Ormsby, Woodford, White, Fellows, Oliver and Quilliam2024). Furthermore, waste dumps create niches for other disease vectors such as protozoa, mosquitos and vermin and can aid the spread of vector-borne diseases such as dengue and malaria (Krystosik et al., Reference Krystosik, Njoroge, Odhiambo, Forsyth, Mutuku and LaBeaud2020). There is also emerging evidence that the use of plastics in a hospital setting may increase the risk of microbial disease transmission; a recent study has identified a pathogenic Pseudomonas bacterial species that “eats” medical plastic, enabling them to persist in the hospital environment (Howard et al., Reference Howard, de Dios, McCarthy, Maslova, Myridakis and Miller2025).

Microplastics and health

Microplastics – fragments of plastic measuring less than 5 mm in length – enter the body through inhalation, ingestion and dermal contact (Enyoh et al., Reference Enyoh, Shafea, Verla, Verla, Qingyue, Chowdhury and Paredes2020). Sources of environmental microplastics include synthetic textiles, vehicle tyres, plastic pellets, personal care products, dust, mechanical recycling facilities, incineration and waste burning and the degradation of plastics in the environment (Brown et al., Reference Brown, MacDonald, Allen and Allen2023; Osman et al., Reference Osman, Hosny, Eltaweil, Omar, Elgarahy, Farghali, Yap, Wu, Nagandran, Batumalaie, Gopinath, John, Sekar, Saikia, Karunanithi, Hatta and Akinyede2023; Suzuki et al., Reference Suzuki, Uchida, Tanaka, Higashi, Takahashi, Kuramochi, Yamaguchi and Osako2024).

We still know very little about the impacts of microplastics on human health. What we do know is that humans are internalising microplastics. Microplastics have been detected in digestive, respiratory, cardiovascular, endocrine, lymphatic, reproductive and urinary tissues and organ systems, as well as in breastmilk, semen, faeces, sputum and urine (Roslan et al., Reference Roslan, Lee, Ibrahim, Tuan Anuar, Yusof, Lai and Brentnall2024). Worryingly, one study reported a rising prevalence of microplastics observed in post-mortem brain tissue from 1997 to 2024 (Nihart et al., Reference Nihart, Garcia, El Hayek, Liu, Olewine, Kingston, Castillo, Gullapalli, Howard, Bleske, Scott, Gonzalez-Estrella, Gross, Spilde, Adolphi, Gallego, Jarrell, Dvorscak, Zuluaga-Ruiz, West and Campen2025), in line with increased plastic production over the same period. Evidence of the health harms is beginning to emerge, and the presence of microplastics has been associated with inflammation (Gaspar et al., Reference Gaspar, Bartman, Coppotelli and Ross2023), cardiovascular events (Marfella et al., Reference Marfella, Prattichizzo, Sardu, Fulgenzi, Graciotti, Spadoni, D’Onofrio, Scisciola, Grotta, Frigé, Pellegrini, Municinò, Siniscalchi, Spinetti, Vigliotti, Vecchione, Carrizzo, Accarino, Squillante, Spaziano, Mirra, Esposito, Altieri, Falco, Fenti, Galoppo, Canzano, Sasso, Matacchione, Olivieri, Ferraraccio, Panarese, Paolisso, Barbato, Lubritto, Balestrieri, Mauro, Caballero, Rajagopalan, Ceriello, D’Agostino, Iovino and Giuseppe Paolisso2024), dementia (Wang et al., Reference Wang, Lin and Shen2024; Nihart et al., Reference Nihart, Garcia, El Hayek, Liu, Olewine, Kingston, Castillo, Gullapalli, Howard, Bleske, Scott, Gonzalez-Estrella, Gross, Spilde, Adolphi, Gallego, Jarrell, Dvorscak, Zuluaga-Ruiz, West and Campen2025) and premature birth (Halfar et al., Reference Halfar, Čabanová, Vávra, Delongová, Motyka, Špaček, Kukutschová, Šimetka and Heviánková2023).

Plastics and air pollution

Burning plastic presents serious risks to human health. As plastic combusts, it releases a cocktail of hazardous air pollutants, including greenhouse gases, volatile organic compounds, heavy metals and particulate matter. Globally, around 19% of managed plastic waste is incinerated (OECD, 2022), and in low- and middle-income countries with limited waste management infrastructure, 40–65% of plastic waste is openly burned (Pathak et al., Reference Pathak, Nichter, Hardon, Moyer, Latkar, Simbaya, Pakasi, Taqueban and Love2023). Exposure to air pollutants released by burning plastics can lead to respiratory and cardiovascular diseases, cancers, diabetes and neurological damage (Pathak et al., Reference Pathak, Nichter, Hardon, Moyer, Latkar, Simbaya, Pakasi, Taqueban and Love2023).

We are all impacted by plastic pollution, but some are more impacted than others

The health risks associated with plastics and plastic pollution are unequally distributed, with economically and politically marginalised populations often experiencing the greatest harms (UNEP, 2023). The 1.1 billion people who reside in informal settlements and slums are among the world’s most vulnerable to plastic pollution. An ambitious treaty must take a human rights–based approach, mainstreaming a right to health as a fundamental human right throughout the treaty, as enshrined in the Universal Declaration of Human Rights (1948) and in line with the World Health Organisation (WHO) Constitution (1948), a legally binding agreement for international health cooperation.

Plastics in the health sector

No one (to the author’s knowledge) is suggesting that all medical plastics should be banned, nor should there be a blanket exemption for medical plastics within the treaty (Street et al., Reference Street, Stringer, Mangesho and Ralston2024). However, we do need to ensure that medical plastics are safe and more sustainable. Exemptions need to be phased and prioritised so that safe and affordable medical plastics are available to all.

Recent years have seen a big rise in the use of disposable single-use medical plastics such as gloves, gowns, catheters and syringes (Rizan et al., Reference Rizan, Mortimer, Stancliffe and Bhutta2020), and reducing single-use plastics in medical settings is challenging due to sterility and safety concerns. However, we need to recognise and support opportunities to boost innovation and take a more circular approach when designing and manufacturing safe medical products. Thirty to fifty percent of healthcare waste is plastic, of which only 5% is recycled (Rizan et al., Reference Rizan, Mortimer, Stancliffe and Bhutta2020).

To reduce plastics in healthcare, we need to differentiate between essential and non-essential single-use plastics and switch to reusable alternatives where possible. Life cycle assessments of disposables vs reusables used in healthcare settings evidence the reduced environmental impact of reusables compared to single-use, and suggest that adopting reusable devices is more sustainable than continuing to use disposable items (Keil et al., Reference Keil, Viere, Helms and Rogowski2023).

A major barrier to efficient waste disposal in healthcare is the improper disposal of non-hazardous materials as clinical waste. By clearly separating hazardous from non-hazardous medical waste, we can improve recycling rates, decrease reliance on incineration and reduce waste management costs (Cho et al., Reference Cho, Withana, Rhee, Lim, Lim, Park and Ok2024). Excessive packaging, often double or triple-wrapped, contributes substantially to plastic waste generated in healthcare settings. We need to eliminate unnecessary wrapping, redesign packaging to minimise waste and use more sustainable materials where possible and safe.

Inclusion of the health sector in global treaty negotiations

WHO plays a critical leadership role in supporting an ambitious global treaty to protect human health and has been present and engaging in the treaty negotiations since INC-1. In 2023, the 76th World Health Assembly adopted a resolution calling on the WHO to scale up efforts to address the impact of chemicals, waste and pollution – including plastics – on human health, and in 2024 the WHO submitted a briefing note to INC-5 entitled “Ensuring the integration of health aspects within the international legally binding instrument on plastic pollution, including in the marine environment” (UNEP, 2024).

To support treaty implementation, the WHO can play a key role in developing evidence-based guidelines and policies on sustainable healthcare practices. These should include recommendations for procurement, the adoption of safe and effective reusable alternatives to single-use plastics and segregation and disposal of medical waste, and should provide technical support and build capacity within health systems to implement these practices effectively. By leveraging global networks, the WHO can assess the state of the science with regard to the health impacts of plastics and provide robust global health-related data sets which can be used to monitor the effectiveness of treaty article implementation. The wider healthcare sector can support the generation of new scientific evidence relating to plastic pollution and seek opportunities for reducing the use of plastics in healthcare settings, as well as lobbying and advocating for ambition within the treaty and the implementation thereof.

Priorities for an ambitious treaty to protect human health

There is clear and growing evidence that plastic poses serious risks to human health. Yet the approach to health protection in the future treaty still hangs in the balance. In order to operationalise the global plastics treaty objective to “protect human health and the environment from plastic pollution,” the treaty must directly address human health impacts in the core obligations of the treaty. The current Chair’s Text includes two options for doing so: Option 1 proposes strengthening and adding references to human health throughout the treaty; Option 2 proposes a standalone article on health. However, these options need not be binary; an ambitious treaty should include a dedicated article on health protection in Article 19, as well as consider complementary approaches in all relevant provisions of the treaty. In light of the range of impacts discussed above, it is imperative to consider and address these impacts across a range of key provisions in the treaty text, including – without limitation – in relation to the most harmful plastic products and chemicals of concern in plastic products (Article 3), to ensure safer and more sustainable plastic product design (Article 5), address releases and leakages, including of microplastics and chemicals of concern (Article 7) and ensure environmentally sound waste management practice that also protect human health (Article 8).

Research into the human health impacts of plastic pollution continues apace. It is vital that the treaty includes mechanisms to update lists of chemicals of concern and other health risks of plastics and microplastics, according to new scientific evidence. Clear criteria must be set with regard to the identification and classification of chemicals of concern, and problematic, unnecessary and avoidable plastics and plastic products. An ambitious treaty should take a precautionary approach, phase out the most harmful plastic products, problematic plastics and plastics containing harmful additives. We need transparency across the value chain. Given that toxic plastic pollutants respect no boundaries, we need globally harmonised rules.

It is likely that INC-5.2 will end with many details yet to be developed before the first Conference of the Parties. It is essential that the treaty includes a process for strengthening treaty mandates through future decisions at the Conference of the Parties. INC-5.2 is not the end; it is the beginning. There is still plenty of work to be done, and health professionals, scientists and the healthcare sector have a key role to play.

Open peer review

To view the open peer review materials for this article, please visit http://doi.org/10.1017/plc.2025.10015.

Author contribution

Cressida Bowyer is the sole author of this work.

Financial support

This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Competing interests

None.

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Author comment: INC-5.2 presents a critical opportunity to protect the health of current and future generations — R0/PR1

Comments

No accompanying comment.

Review: INC-5.2 presents a critical opportunity to protect the health of current and future generations — R0/PR2

Conflict of interest statement

The author is my colleague

Comments

Dear Cress,

Thank you for submitting the revised version of your letter. I am pleased to confirm that it has been accepted for publication in Cambridge Prisms: Plastics. Your contribution adds an extremely valuable perspective to the discussion ahead on INC-5.2, and I appreciate your engagement with the review process. I look forward to sharing your letter as part of the upcoming collection.

In my final review, I noticed a small number of additional possible edits. Please could you consider these during the final pre-publication proofing of the letter:

An impact statement is needed for the letter.

Page 4, Line 32. Should “an” be inserted between “is” and “imperative’?

Page 4, Line 52. Should “yet to be developed before” be replaced with “deferred to”?

Many thanks again for your letter, and best wishes

Steve

Recommendation: INC-5.2 presents a critical opportunity to protect the health of current and future generations — R0/PR3

Comments

No accompanying comment.

Decision: INC-5.2 presents a critical opportunity to protect the health of current and future generations — R0/PR4

Comments

No accompanying comment.