Hostname: page-component-cb9f654ff-w5vf4 Total loading time: 0 Render date: 2025-09-01T04:55:50.489Z Has data issue: false hasContentIssue false
  • English
  • Français

Positive and Negative Schizophrenic Symptoms and the Role of Dopamine

Published online by Cambridge University Press:  29 January 2018

A. V. P. Mackay
A. V. P. Mackay*
Affiliation:
MRC Neurochemical Pharmacology Unit, Cambridge
Get access Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Information

Type
Discussion
Information
The British Journal of Psychiatry , Volume 137 , Issue 4 , October 1980 , pp. 379 - 383
Copyright
Copyright © Royal College of Psychiatrists, 1980 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Andrews, W. M. (1973) Long-acting tranquillisers and the amotivational syndrome in the treatment of schizophrenics. In Community Management of the Schizophrenic in Chemical Remission (ed. E. H. King), 1–4, Excerpta Medica, Amsterdam.Google Scholar
Bird, E. D., Spokes, E. G. & Iversen, L. L. (1979) Increased dopamine concentration in limbic areas of brain from patients dying with schizophrenia. Brain, 102, 347–60.CrossRefGoogle ScholarPubMed
Bleuler, E. (1911) Dementia Praecox or the Group of Schizophrenias. Translated by Zinkin, H., International Universities Press, 1950, New York.Google Scholar
Bowers, M. B. (1974) Central dopamine turnover in schizophrenic syndromes. Archives of General Psychiatry, 31, 50–4.CrossRefGoogle ScholarPubMed
Chouinard, G. & Jones, B. D. (1978) SchizoSphrenia as dopamine-deficiency disease. Lancet, ii, 99–100.CrossRefGoogle Scholar
Crow, T. J. (1980) Molecular pathology of schizophrenia; more than one disease process? British Medical Journal, 280, 66–8.CrossRefGoogle ScholarPubMed
Johnstone, E. C., Crow, T. J., Frith, C. D., Stevens, M., Kreel, L. & Husband, J. (1978) The dementia of dementia praecox. Acta Psychiatrica Scandinavica, 57, 305–24.CrossRefGoogle ScholarPubMed
Kraepelin, E. (1913) Dementia Praecox and Paraphrenia. Translated by Barclay, R. M. and Robertson, G. M. E. & Livingstone, S. (1919), Edinburgh.Google Scholar
Lee, T., Seeman, P., Rajput, A., Farley, I. J. & Hornykiewicz, O. (1978) Receptor basis for dopaminergic supersensitivity in Parkinson's disease. Nature, 273, 59–61.Google ScholarPubMed
Mackay, A. V. P., Bird, E. D., Iversen, L. L., Spokes, E. G., Creese, I. & Snyder, S. H. (1980) Dopaminergic abnormalities in post mortem schizophrenic brain. In Long-Term Effects of Neuroleptics, Advances in Biochemical Psychopharmacology, Vol. 24 (eds. F. Cattabeni, G. Racagni, P. F. Spano & E. Costa), 325–33, Raven Press, New York.Google Scholar
Owen, F., Cross, A. J., Crow, T. J., Longden, A., Poulter, M. & Riley, G. J. (1978) Increased dopamine receptor sensitivity in schizophrenia. Lancet, ii, 223–5.Google Scholar
Owens, D. G. C. & Johnstone, E. C. (1980) The disabilities of chronic schizophrenia—their nature and the factors contributing to their development. British Journal of Psychiatry, 136, 384–5.CrossRefGoogle Scholar
Post, R. M., Fink, E., Carpenter, W. T. & Goodwin, F. F. (1975) Cerebrospinal fluid amine metabolites in acute schizophrenia. Archives of General Psychiatry, 32, 1063–9.CrossRefGoogle ScholarPubMed
Roth, R. H., Walters, J. R. & Aghajanian, G. K. (1973) Effect of impulse flow on the relase and synthesis of dopamine in the rat striatum. In Frontiers in Catecholamine Research, (eds. E. Usdin and S. H. Snyder), 567–74, Pergamon Press Inc, Oxford.Google Scholar
Schwartz, J. C., Costentin, J., Martres, M. P., Protais, P. & Baudry, M. (1978) Modulation of receptor mechanisms in the CNS: hyper- and hyposensitivity to catecholamines. Neuropharmacology, 17, 665–85.CrossRefGoogle ScholarPubMed
Stein, L. & Wise, C. D. (1971) Possible etiology of schizophrenia; progressive damage to the noradrenergic reward system by 6-hydroxydopamine. Science, 171, 1032–6.CrossRefGoogle Scholar
Sutter, J. M., Debrie, M. L. & Scotto, J. C. (1966) Recherches sur les effets psychologiques de la fluphenazine dans les psychoses chroniques. Annales Médico-Psychologiques (Paris), 124, 19–33.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979) Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry, 36, 735–9.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.