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Isotretinoin use, mood changes and suicidality. What is the link? Commentary, Duan and Chen

Published online by Cambridge University Press:  22 July 2025

Yinan Duan  and
Runsen Chen Open the ORCID record for Runsen Chen [Opens in a new window]
Yinan Duan
Affiliation:
Vanke School of Public Health, Tsinghua University, Beijing, China
Runsen Chen*
Affiliation:
Vanke School of Public Health, Tsinghua University, Beijing, China
*
Correspondence: Runsen Chen. Email: runsenchen@tsinghua.edu.cn
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Abstract

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Keywords

Depressionsuicideclinical practice

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Type
Commentary
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The British Journal of Psychiatry , First View , pp. 1 - 2
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Royal College of Psychiatrists

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References

Samamé, C. Isotretinoin use, mood changes and suicidality. What is the link? BJPsych, 2025, in press.Google ScholarPubMed
Paljarvi, T, McPherson, T, Luciano, S, Herttua, K, Fazel, S. Isotretinoin and adverse neuropsychiatric outcomes: retrospective cohort study using routine data. Br J Dermatol 2022; 187: 64–72.CrossRefGoogle ScholarPubMed
Chen, Y-H, Wang, W-M, Chung, C-H, Tsao, C-H, Chien, W-C, Hung, C-T. Risk of psychiatric disorders in patients taking isotretinoin: a nationwide, population-based, cohort study in Taiwan. J Affect Disord 2022; 296: 277–82.CrossRefGoogle ScholarPubMed
Droitcourt, C, Poizeau, F, Kerbrat, S, Balusson, F, Drezen, E, Happe, A, et al. Isotretinoin and risk factors for suicide attempt: a population-based comprehensive case series and nested case–control study using 2010–2014 French health insurance data. J Eur Acad Dermatol Venereol 2020; 34: 1293–301.CrossRefGoogle ScholarPubMed
Singer, S, Tkachenko, E, Sharma, P, Barbieri, JS, Mostaghimi, A. Psychiatric adverse events in patients taking isotretinoin as reported in a food and drug administration database from 1997 to 2017. JAMA Dermatol 2019; 155: 1162.CrossRefGoogle Scholar
Wysowski, DK, Pitts, M, Beitz, J. An analysis of reports of depression and suicide in patients treated with isotretinoin. J Am Acad Dermatol 2001; 45: 515–9.CrossRefGoogle ScholarPubMed
Hu, P, Van Dam, A-M, Wang, Y, Lucassen, PJ, Zhou, J-N. Retinoic acid and depressive disorders: evidence and possible neurobiological mechanisms. Neurosci Biobehav Rev 2020; 112: 376–91.CrossRefGoogle ScholarPubMed
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