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Thalamocortical connectivity and its relationship with symptoms and cognition across the psychosis continuum

Published online by Cambridge University Press:  01 September 2022

Ian S. Ramsay Open the ORCID record for Ian S. Ramsay [Opens in a new window] ,
Bryon Mueller ,
Yizhou Ma ,
Chen Shen  and
Scott R. Sponheim
Ian S. Ramsay*
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of Minnesota School of Medicine, Minneapolis, MN, USA
Bryon Mueller
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of Minnesota School of Medicine, Minneapolis, MN, USA
Yizhou Ma
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA Maryland Psychiatric Research Center, University of Maryland School of Medicine, Catonsville, MD, USA
Chen Shen
Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
Scott R. Sponheim
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of Minnesota School of Medicine, Minneapolis, MN, USA Minneapolis Veterans Affairs Healthcare System, Minneapolis, MN, USA
*
Author for correspondence: Ian S. Ramsay, E-mail: ramsa045@umn.edu
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Abstract

Background

Coordination between the thalamus and cortex is necessary for efficient processing of sensory information and appears disrupted in schizophrenia. The significance of this disrupted coordination (i.e. thalamocortical dysconnectivity) to the symptoms and cognitive deficits of schizophrenia is unclear. It is also unknown whether similar dysconnectivity is observed in other forms of psychotic psychopathology and associated with familial risk for psychosis. Here we examine the relevance of thalamocortical connectivity to the clinical symptoms and cognition of patients with psychotic psychopathology, their first-degree biological relatives, and a group of healthy controls.

Method

Patients with a schizophrenia-spectrum diagnosis (N = 100) or bipolar disorder with a history of psychosis (N = 33), their first-degree relatives (N = 73), and a group of healthy controls (N = 43) underwent resting functional MRI in addition to clinical and cognitive assessments as part of the Psychosis Human Connectome Project. A bilateral mediodorsal thalamus seed-based analysis was used to measure thalamocortical connectivity and test for group differences, as well as associations with symptomatology and cognition.

Results

Reduced connectivity from mediodorsal thalamus to insular, orbitofrontal, and cerebellar regions was seen in schizophrenia. Across groups, greater symptomatology was related to less thalamocortical connectivity to the left middle frontal gyrus, anterior cingulate, right insula, and cerebellum. Poorer cognition was related to less thalamocortical connectivity to bilateral insula. Analyses revealed similar patterns of dysconnectivity across patient groups and their relatives.

Conclusions

Reduced thalamo-prefrontal-cerebellar and thalamo-insular connectivity may contribute to clinical symptomatology and cognitive deficits in patients with psychosis as well as individuals with familial risk for psychotic psychopathology.

Keywords

CognitionfMRIpsychosissymptomsthalamocortical connectivity

Information

Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 12 , September 2023 , pp. 5582 - 5591
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Copyright © The Author(s), 2022. Published by Cambridge University Press

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