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Structural brain changes in patients with anorexia nervosa

Published online by Cambridge University Press:  09 July 2009

R. J. Dolan ,
J. Mitchell  and
A. Wakeling
R. J. Dolan*
Affiliation:
Academic Department of Psychiatry, Royal Free Hospital, London
J. Mitchell
Affiliation:
Academic Department of Psychiatry, Royal Free Hospital, London
A. Wakeling
Affiliation:
Academic Department of Psychiatry, Royal Free Hospital, London
*
1Address for correspondence: Dr R. J. Dolan, The National Hospital, Queen Square, London WC1N 3BG.
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Synopsis

Twenty-five patients with anorexia nervosa were compared with 17 normal healthy control subjects in terms of their cerebral computed tomographic (CT) scan appearances. The patients displayed significantly greater ventricular and sulcal enlargement when compared to control subjects. There were no relationships between the CT scan appearance and clinical indices of illness severity or weight loss in the patient group. In 14 patients who had repeat scans after attaining normal body weight, no significant change was observed in the ventricular appearance, but there was a significant lessening in the degree of sulcal widening.

Information

Type
Research Article
Information
Psychological Medicine , Volume 18 , Issue 2 , May 1988 , pp. 349 - 353
Copyright
Copyright © Cambridge University Press 1988

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References

Artmann, H., Grau, H., Adelmann, M. & Scleiffer, R. (1985). Reversible and non-reversible enlargement of cerebrospinal fluid spaces in anorexia nervosa. Neuroradiology 27, 304–312.CrossRefGoogle ScholarPubMed
Bentson, J., Reza, M., Winter, J. & Wilson, G. (1978). Steroids and apparent cerebral atrophy on computed tomography scans. Journal of Computer Assisted Tomography 2, 16–23.CrossRefGoogle ScholarPubMed
Carlen, P. L., Wortzman, G., Holgate, R C., Wilkinson, D. A. & Rankin, J. G. (1978). Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomographic scans. Science 200, 1076–1078.CrossRefGoogle Scholar
Datlof, S., Coleman, P. D., Forbes, G. B. & Kreipe, R. E. (1986). Ventricular dilation on CAT scans of patients with anorexia nervosa. American Journal of Psychiatry 143, 96–98.Google ScholarPubMed
Dolan, R J., Calloway, S. P. & Mann, A. H. (1985). Cerebral ventricular size in depressed subjects Psychological Medicine 15, 873–878.CrossRefGoogle ScholarPubMed
Dolan, R. J., Calloway, S. P., Thacker, P. F. & Mann, A. H. (1986). The cerebral cortical appearance in depressed subjects. Psychological Medicine 16, 775–779.CrossRefGoogle ScholarPubMed
Enzmen, D. R & Lane, B. (1977). Cranial computed tomography findings in anorexia nervosa. Journal of Computer Assisted Tomography 1, 410–414.CrossRefGoogle Scholar
Hampsher, K., Halmi, K. A. & Benton, A. L. (1981). Prediction of outcome in anorexia nervosa from neuropsychological status. Psychiatry Research 4, 79–88.CrossRefGoogle Scholar
Haug, G. (1977). Age and sex dependence of the size of normal ventricles in computed tomography. Neuroradiology 10, 205–213Google Scholar
Heidrich, R. & Schmidt-Matthias, H. (1961). Encephalographische Befunde bei Anorexia Nervosa. Archiv für Psychiatrie und Nervenkrankheiten 202, 183–201.CrossRefGoogle Scholar
Heinz, R. E., Martinez, J. & Haegeli, A. (1977). Reversibility of cerebral atrophy in anorexia nervosa. Journal of Computer Assisted Tomography 1, 414–418CrossRefGoogle ScholarPubMed
Kay, D. W., Schapira, K. & Brandon, S. (1967). Early factors in anorexia nervosa compared with non-anorexic groups. A preliminary report with a discussion on methdology. Journal of Psychiatric Research 11, 133–139.Google Scholar
Kolmeyer, K., Lehmkuhl, G. & Poutska, F. (1983). Computed tomography of anorexia nervosa. American Journal of Neuroradiology 4, 437–438.Google Scholar
Krieg, K. C., Backmund, H. & Pirke, K. M. (1986). Endocrine, metabolic and brain morphological abnormalities in patients with eating disorders. International Journal of Eating Disorders 5, 999–1005.3.0.CO;2-A>CrossRefGoogle Scholar
Lankenau, H., Swigar, M. E., Bhimani, S., Luchins, S. & Quinlan, D. M. (1985). Cranial CT scans in eating disorder patients and controls. Comprehensive Psychiatry 26, 136–147.CrossRefGoogle ScholarPubMed
Martin, P. F. (1955). Pathologie des aspects neurologiques et psychiatriques dans quelques manifestations carentielles avec troubles digestifs et neuroendocriniens. II. Études des altérations du systéme nerveux central dans deux cas d'anorexie survenue chez la jeune fille (dite anorexie mantale). Helvetica Medica Acta 22 522–529.Google Scholar
Nussbaum, M., Shenker, I. R., Marc, J. & Klein, M. (1980). Cerebral atrophy and anorexia nervosa. Journal of Paediatrics 96, 867–869.CrossRefGoogle ScholarPubMed
Okuno, T., Ito, M., Konishi, Y., Yashioka, M. & Nakana, Y. (1980). Cerebral atrophy following ACTH therapy. Journal of Computer Assisted Tomography 4, 20–23.CrossRefGoogle ScholarPubMed
Reveley, A. M., Reveley, M. A. & Murray, R. M. (1984). Cerebral ventricular enlargement in non-genetic schizophrenia: a controlled twin study. British Journal of Psychiatry 144, 89–93.CrossRefGoogle ScholarPubMed
Ron, M. A. (1983). The alcoholic brain: CT scan and psychological findings. Psychological Medicine Monograph Suppt. 3 8–35.Google Scholar
Russell, G. F M. (1970). Anorexia nervosa: its identity as an illness and its treatment. In Modern Trends in Psychological Medicine Vol. 2 (ed. Price, J. H.), pp. 131–164. Butterworths: London.Google Scholar
Sein, P., Pearson, S., Nicol, A. R. & Hall, K. (1981). Anorexia nervosa and pseudo-atrophy of the brain. British Journal of Psychiatry 139, 257–258.CrossRefGoogle ScholarPubMed
Turner, S. W., Toone, B. K. & Brett-Jones, J. R. (1986). Computerised tomographic scan changes in early schizophrenia– preliminary findings. Psychological Medicine 16, 219–225.CrossRefGoogle ScholarPubMed