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Covariation between spontaneous neural activity in the insula and affective temperaments is related to sleep disturbance in individuals with major depressive disorder

Published online by Cambridge University Press:  16 December 2019

Huawang Wu ,
Yingjun Zheng ,
Qianqian Zhan ,
Jie Dong ,
Hongjun Peng ,
Jinguo Zhai ,
Jingping Zhao ,
Shenglin She  and
Chao Wu Open the ORCID record for Chao Wu [Opens in a new window]
Huawang Wu
Affiliation:
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510370, China
Yingjun Zheng
Affiliation:
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510370, China
Qianqian Zhan
Affiliation:
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510370, China
Jie Dong
Affiliation:
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510370, China
Hongjun Peng
Affiliation:
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510370, China
Jinguo Zhai
Affiliation:
School of Mental Health, Jining Medical University, Jining 272067, China
Jingping Zhao
Affiliation:
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510370, China
Shenglin She*
Affiliation:
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510370, China
Chao Wu*
Affiliation:
School of Nursing, Peking University Health Science Center, Beijing 100191, China
*
Author for correspondence: Shenglin She, E-mail: shenglinshe@gzhmu.edu.cn; Chao Wu, E-mail: chelseawu@pku.edu.cn
Author for correspondence: Shenglin She, E-mail: shenglinshe@gzhmu.edu.cn; Chao Wu, E-mail: chelseawu@pku.edu.cn
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Abstract

Background

Affective temperaments have been considered antecedents of major depressive disorder (MDD). However, little is known about how the covariation between alterations in brain activity and distinct affective temperaments work collaboratively to contribute to MDD. Here, we focus on the insular cortex, a critical hub for the integration of subjective feelings, emotions, and motivations, to examine the neural correlates of affective temperaments and their relationship to depressive symptom dimensions.

Methods

Twenty-nine medication-free patients with MDD and 58 healthy controls underwent magnetic resonance imaging scanning and completed the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS). Patients also received assessments of the Hamilton Depression Rating Scale (HDRS). We used multivariate analyses of partial least squares regression and partial correlation analyses to explore the associations among the insular activity, affective temperaments, and depressive symptom dimensions.

Results

A profile (linear combination) of increased fractional amplitude of low-frequency fluctuations (fALFF) of the anterior insular subregions (left dorsal agranular–dysgranular insula and right ventral agranuar insula) was positively associated with an affective-temperament (depressive, irritable, anxious, and less hyperthymic) profile. The covariation between the insula-fALFF profile and the affective-temperament profile was significantly correlated with the sleep disturbance dimension (especially the middle and late insomnia scores) in the medication-free MDD patients.

Conclusions

The resting-state spontaneous activity of the anterior insula and affective temperaments collaboratively contribute to sleep disturbances in medication-free MDD patients. The approach used in this study provides a practical way to explore the relationship of multivariate measures in investigating the etiology of mental disorders.

Keywords

Affective temperamentsfractional amplitude of low-frequency fluctuationsinsulamajor depressive disorderpartial least squares

Information

Type
Original Article
Information
Psychological Medicine , Volume 51 , Issue 5 , April 2021 , pp. 731 - 740
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Copyright
Copyright © Cambridge University Press 2019

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Footnotes

*

These authors contributed equally to this work.

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