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n-3 Polyunsaturated fatty acids and immune function

Published online by Cambridge University Press:  18 April 2008

Dayong Wu  and
Simin Nikbin Meydani
Dayong Wu
Affiliation:
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tuffs University, Boston, MA 02111, USA
Simin Nikbin Meydani*
Affiliation:
Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tuffs University, Boston, MA 02111, USA
*
*Corresponding author: Dr Simin Nikbin Meydani, fax +1 617 556 3224, email S_Meydani_im@hnrc.tufts.edu
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Abstract

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Information

Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 57 , Issue 4 , November 1998 , pp. 503 - 509
Copyright
Copyright © The Nutrition Society 1998

References

Aki, H, Morinaga, SI, Yamazaki, K, Suzuki, H & Nakamura, N (1992) Reduction of delayed-type hypersensitivity by the injection of n-3 polyunsaturated fatty acid in mice. Transplantation 54, 511–514.Google Scholar
Berger, A, German, JB, Chiang, BL, Ansari, AA, Keen, CL, Fletcher, MP & Gershwin, ME (1993) Influence of feeding unsaturated fats on growth and immune status of mice. Journal of Nutrition 123, 225–233.Google ScholarPubMed
Brunda, MJ, Heberman, RB & Holden, HT (1980) Inhibition of natural killer cell activity by prostaglandins. Journal of Immunology 124, 2682–2687.CrossRefGoogle ScholarPubMed
Calder, PC (1996) Immunomodulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids. Proceedings of the Nutrition Society 55, 737774.CrossRefGoogle ScholarPubMed
Calder, PC & Newsholme, EA (1992) Polyunsaturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production. Clinical Science 37, 695–700.CrossRefGoogle Scholar
Caughey, GE, Mantzioris, E, Gibson, RA, Cleland, LG & James, MJ (1996) The effect on human tumor necrosis factor α and interleukin 1β production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. American Journal of Clinical Nutrition 63, 116–122.CrossRefGoogle ScholarPubMed
Chang, HR, Dulloo, AG, Vladoianu, IR, Piguet, PF, Arsenijevic, D, Girardier, L & Pechere, JC (1992) Fish oil decreases natural resistance of mice infection with Salmonella typhimurium. Metabolism 41. 1–2.CrossRefGoogle ScholarPubMed
Christophe, B & Pascaud, M (1990) Effects of moderate dietary supplementations with n-3 fatty acids on macrophage eicosanoid synthesis in the rat. Biochimica et Biophysica Acta 1047, 19–28.Google Scholar
Clandinin, MT, Cheema, S, Field, CJ, Garg, ML, Venkatraman, J & Clandinin, TR (1991) Dietary fat: exogenous determination of membrane structure and cell function. FASEB Journal 5, 2761–2769.CrossRefGoogle ScholarPubMed
Davits, FA & Nugteren, A (1988) The urinary excretion of prostaglandin E and their corresponding tetranor metabolites by rats fed a diet rich in eicosapentaenoate. Biochimica et Biophysica Acta 958, 289–299.Google Scholar
Dyerberg, J & Bang, HO (1979) Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet ii, 433–435.CrossRefGoogle Scholar
Dyerberg, J, Bang, HO, Stoffersen, E, Moncada, S & Vane, J (1978) Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis. Lancet ii, 117–119.CrossRefGoogle Scholar
Endres, S, Ghorbani, R, Kelley, VE, Georgilis, K, Lonneman, G, Van der Meer, WM, Cannon, JG, Rogers, TS, Klempner, MS, Webber, PC, Schaefer, EJ, Wolf, SM & Dinarello, DA (1989) The effect of dietary supplementation with (n-3) polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. New England Journal of Medicine 320, 265–271.CrossRefGoogle ScholarPubMed
Endres, S, Meydani, SN, Ghorbani, R, Schindler, R & Dinarello, CA (1993) Dietary n-3 fatty acids suppress interleukin-2 production and mononuclear cell proliferation. Journal of Leukocyte Biology 54, 599–603.CrossRefGoogle ScholarPubMed
Engstrom, K, Luostarinen, R & Saldeen, T (1996) Whole blood production of thromboxane, prostacyclin and leukotriene B4 after dietary fish oil supplementation in man: effect of vitamin E. Prostaglandins, Leukotrienes and Essential Fatty Acids 54, 419–425.CrossRefGoogle ScholarPubMed
Farwer, SR (1994) The vitamin E nutritional status of rats fed on diets high in fish oil, linseed oil, or sunflower seed oil. British Journal of Nutrition 72, 127–145.CrossRefGoogle ScholarPubMed
Fernandes, G & Venkatraman, JT (1993) Role of omega-3 fatty acids in health and disease. Nutrition Research 13, S19–S45.CrossRefGoogle Scholar
Fowler, KH, Chapkin, RS & McMurray, DN (1993) Effects of purified dietary n-3 ethyl esters on murine T lymphocyte function. Journal of Immunology 151, 5186–5197.CrossRefGoogle Scholar
Fritsche, KL, Cassity, NA & Huang, S-C (1992) Dietary (n-3) fatty acid and vitamin E interactions in rats: effects on vitamin E status, immune cell prostaglandin E production and primary anti-body response. Journal of Nutrition 122, 1009–1018.CrossRefGoogle Scholar
Fritsche, KL, Shahbazian, LM, Feng, C & Berg, JN (1997) Dietary fish oil reduces survival and impairs bacterial clearance in C3H/ Hen mice challenged with Listeria monocytogenes. Clinical Science 92, 95–101.CrossRefGoogle ScholarPubMed
Goodman, MG & Weigle, WO (1980) Modulation of lymphocyte activation I. Inhibition of an oxidation product of arachidonic acid. Journal of Immunology 125, 593–600.CrossRefGoogle ScholarPubMed
Goodwin, JS, Messner, RP & Peake, GT (1974) Prostaglandin suppression of mitogen stimulated leukocytes in culture. Journal of Clinical Investigation 4, 368–378.Google Scholar
Goodwin, JS & Webb, DR (1980) Regulation of the immune response by prostaglandins. Clinical Immunology and Immunopathology 15, 106–122.CrossRefGoogle ScholarPubMed
Gordon, D, Bray, M & Morley, J (1976) Control of Iymphokine secretion by prostaglandins. Nature 262, 401–402.CrossRefGoogle ScholarPubMed
Hollander, D, Dadufabza, VD & Sletten, EG (1984) Does essential fatty acid absorption change with age? Journal of Lipid Research 25, 129–134.CrossRefGoogle Scholar
Huang, DH, Boudreau, M & Chanmugam, P (1988) Dietary linolenic acid and longer-chain n-3 fatty acids: comparison of effects on arachidonic acid metabolism in rats. Journal of Nutrition 118, 427–437.Google Scholar
Hughes, DA & Pinder, AC (1996) Influence of n-3 polyunsaturated fatty acids (PUFA) on the antigen-presenting function of human monocytes. Biochemical Society Transactions 24, 389S.CrossRefGoogle ScholarPubMed
Hughes, DA, Pinder, AC, Piper, Z, Johnson, IT & Lund, EK (1996 a) Fish oil supplementation inhibits the expression of major histocompatibility complex class I1 molecules and adhesion molecules on human monocytes. American Journal of Clinical Nutrition 63, 267–272.CrossRefGoogle Scholar
Hughes, DA, Southon, S & Pinder, AC (1996 b) (n-3) Polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro. Journal of Nutrition 126, 603–610.CrossRefGoogle ScholarPubMed
Hunter, JE (1987) Correspondence: More on fish oil (letter). New England Journal of Medicine 316, 626.Google Scholar
Jolly, CA, Jiang, Y-H, Chapkin, RS& McMurray, DN (1997) Dietary (n-3) polyunsaturated fatty acids suppress murine lympho-proliferation, interleukin-2 secretion, and the formation of diacylglycerol and ceramide. Journal of Nutrition 127, 37–43.CrossRefGoogle Scholar
Jolly, CA, Laurenz, JC, McMurray, DN & Chapkin, RS (1996) Diacylglycerol and ceramide kinetics in primary cultures of activated T-lymphocytes. Immunology Letters 49, 43–48.CrossRefGoogle ScholarPubMed
Kelley, DS, Nelson, GJ, Serrato, CM, Schmidt, PC & Branch, LB (1988) Effects of type of dietary fat on indices of immune status of rabbits. Journal of Nutrition 118, 1376–1384.CrossRefGoogle ScholarPubMed
Knapp, HR (1990) Prostaglandins in human semen during fish oil ingestion: evidence for in vivo cyclooxygenase inhibition and appearance of novel trienoic compound. Prostaglandins 39, 407–423.CrossRefGoogle Scholar
Knusden, PJ, Dinarello, CA & Strom, TB (1986) Prostaglandins post-transcriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate. Journal of Immunology 137, 3189–3194.Google Scholar
Kramer, TR, Schoene, N, Dougless, LW, Judd, JT, Ballard-Barbash, R, Taylor, PR, Bhagavan, N & Nair, PP (1991) Increased vitamin E intake restores fish oil-induced suppressed blastogenesis of mitogenic-stimulated T lymphocytes. American Journal of Clinicul Nutrition 54, 896–902.CrossRefGoogle Scholar
L'Abbe, MR, Trick, KD & Beare-Rogers, J (1991) Dietary (n-3) fatty acids affect rat heart, liver and aorta protective enzyme activities and lipid peroxidation. Journal of Nutrition 121, 1331–1340.CrossRefGoogle ScholarPubMed
Leaver, HA, Howie, A & Wilson, NH (1991) The biosynthesis of the 3-series prostaglandins in rat uterus after alpha-linolenic acid feeding, mass spectroscopy of prostaglandins E and F produced by rat uteri in tissue culture. Prostaglandins, Leukotrienes and Essential Fatty Acids 42, 217–224.CrossRefGoogle Scholar
Lee, TH, Hoover, R, Williams, JD, Sperling, J, Raralese, J, Spur, BW, Robinson, DR, Corey, EJ, Lewis, RA & Austen, KF (1985) Effect of dietary enrichment with eicosapentaenoic and docosa-hexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. New England Journal of Medicine 312, 1217–1224.CrossRefGoogle Scholar
Leitch, AG, Lee, TH, Ringel, EW, Prickett, JD, Robinson, WR, Pyme, SG, Corey, EJ, Drazen, JM, Austen, KF & Lewis, RA (1985) Immunologically induced generation of tetraene and pentaene leukotrienes in the peritoneal cavities of menhaden-fed rats. Journal of Immunology 132, 2559–2565.CrossRefGoogle Scholar
Meydani, M, Natiello, F, Goldin, B, Free, N, Woods, M, Schaefer, E, Blumberg, JB & Gorbach, SL (1991 b) Effect of long-term fish oil supplementation on vitamin E status and lipid peroxidation in women. Journal of Nutrition 121, 484–491.CrossRefGoogle ScholarPubMed
Meydani, SN, Barklund, MP, Liu, S, Meydani, M, Miller, RA, Cannon, JG, Morrow, FD, Rocklin, R & Blumberg, JB (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. American Journal of Clinical Nutrition 52, 557–563.CrossRefGoogle ScholarPubMed
MeydaniSN, SN,, Endres, S, Woods, MN, Goldin, RD, Soo, C, Morrill-Labrode, A, Dinarello, CA & Gorbach, SL (1991 a) Oral (n-3) fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: Comparison between young and older women. Journal of Nutrition 121, 547–555.CrossRefGoogle Scholar
Meydani, SN, Lichtenstein, AH, Meydani, M, Goldin, BR, Rasmussen, H, Dinarello, CA & Schaefer, E (1993) Immunologic effects of National Cholesterol Education Panel (NCEP) Step-2 diets with and without fish-derived n-3 fatty acid enrichment. Journal of Clinical Investigation 92, 105–113.CrossRefGoogle ScholarPubMed
Meydani, SN, Meydani, M, Verdon, CP, ShapiroAC, AC,, Blumberg, JB & Hayes, KC (1986) Vitamin E supplementation suppresses prostaglandin E2 synthesis and enhances the immune response of aged mice. Mechanisms of Ageing and Development 34, 191–201.CrossRefGoogle ScholarPubMed
Meydani, SN, Shapiro, AC, Meydani, M, Macauley, JB & Blumberg, JB (1987) Effect of age and dietary fat (fish, corn and coconut oils) on tocopherol status of C57BL/6NIA mice. Lipids 22, 345–350.CrossRefGoogle ScholarPubMed
Meydani, SN, Yogeeswaran, G, Liu, S, Baskar, S & Meydani, M (1988) Fish oil and tocopherol-induced changes in natural killer cell-mediated cytotoxicity and PGE2 synthesis in young and old mice. Journal of Nutrition 118, 1245–1252.CrossRefGoogle ScholarPubMed
Miller, RA (1994) Aging and immune function, cellular and biochemical analyses. Experimental Gerontology 29, 21–35.CrossRefGoogle ScholarPubMed
Muggli, R (editor) (1989) Dietary fish oils increase the requirement for vitamin E in humans. St John's, Nfld., Canada: Biochemical Publishers & Distributors.Google Scholar
Payan, DG, Wong, MYS & Chernov-Rogan, T (1986) Alterations in human leukocyte function induced by ingestion of eicosa-pentaenoic acid. Journal of Clinical Immunology 6, 402–410.CrossRefGoogle Scholar
Piche, LA, Draper, HH & Cole, PD (1988) Malondialdehyde excretion by subjects consuming cod liver oil versus a concentrate of n-3 fatty acids. Lipids 23, 370–371.CrossRefGoogle Scholar
Plaunt, M (1979) The role of cyclic AMP in modulating cytotoxic T lymphocytes. Journal of Immunology 123, 692–701.CrossRefGoogle Scholar
Roder, JC & Klein, M (1979) Target-effector interaction in the natural killer cell system. Journal of Immunology 123, 2785–2790.CrossRefGoogle ScholarPubMed
Rola-Plezczunski, M (1985) Imunoregulation by leukotrienes and other lipoxygenase metabolites. Immunology Today 6, 302–307.CrossRefGoogle Scholar
Santoli, D & Zurier, RB (1989) Prostaglandin E precursor fatty acids inhibit human IL-2 production by a prostaglandin E-dependent mechanism. Journal of Immunology 143, 1303–1309.CrossRefGoogle Scholar
Shapiro, AC, Wu, D, Hayek, MG, Meydani, M & Meydani, SN (1994) Role of eicosanoids and vitamin E in fish oil-induced changes of splenocyte proliferation to T cell mitogens in mice. Nutrition Research 14, 1339–1354.CrossRefGoogle Scholar
Shapiro, AC, Wu, D & Meydani, SN (1993) Eicosanoids derived from arachidonic and eicosapentaenoic acids inhibit T cell proliferative response. Prostaglandins 45, 229–240.CrossRefGoogle ScholarPubMed
Simopoulos, AP & Salem, N (1986) Purslane: a terrestrial source of omega-3 fatty acids. New England Journal of Medicine 315, 833.Google ScholarPubMed
Siskind, GW (1980) Immunological aspects of aging: An overview. In Biological Mechanism in Aging, pp. 455–467 [Schimke, RT, editor]. Bethesda, MA: National Institutes of Health.Google Scholar
Tappia, PS, Man, WJ & Grimble, RF (1995) Influence of unsaturated fatty acids on the production of tumor necrosis factor and interleukin-6 by rat peritoneal macrophages. Molecular and Cellular Biochemistry 143, 89–98.CrossRefGoogle ScholarPubMed
VanMeter, AR, Ehringer, WD, Stillwell, W, Blumenthal, EJ & Jenski, LJ (1994) Aged lymphocyte proliferation following incorporation and retention of dietary omega-3 fatty acids. Mechanisms of Ageing and Development 75, 95–114.CrossRefGoogle ScholarPubMed
Wander, RC, Du, S-H, Ketchum, SO & Rowe, KE (1996) α-Tocopherol influences in vivo indices of lipid peroxidation in postmenopausal women given fish oil. Journal of Nutrition 126, 643–652.CrossRefGoogle ScholarPubMed
Wander, RC, Hall, JA, Gradin, JL, Du, S-H & Jewell, DE (1997) The ratio of dietary (n-6) to (n-3) fatty acids influences immune system function, eicosanoid metabolism, lipid peroxidation, and vitamin E status in aged dogs. Journal of Nutrition 127, 1198–1205.CrossRefGoogle Scholar
Webb, DR, Rogers, TJ & Nowowiejski, E (1980) Endogenous prostaglandin synthesis and the control of lymphocyte function. Proceedings of the New York Academy of Sciences USA 332, 260–270.Google Scholar
Whelan, KS, Broughton, B, Lokesh, B & Kinsella, JE (1991) In vivo formation of leukotriene E5 by murine peritoneal cells. Prostaglandins 41, 29–41.CrossRefGoogle ScholarPubMed
Wu, D, Meydani, SN, Meydani, M, Hayek, MG, Huth, P & Nicolosi, RJ (1996) Immunological effects of marine- and plant-derived (n-3) polyunsaturated fatty acids in non-human primates. American Journal of Clinical Nutrition 63, 273–280.CrossRefGoogle Scholar
Zoschke, DC & Messner, RP (1984) Suppression of human lymphocyte mitogenesis mediated by phagocyte-released reactive oxygen species, comparative activities in normal and chronic granulomatous disease. Clinical Immunology and lmmunopathology 32, 29–40.CrossRefGoogle ScholarPubMed