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Anaphylactoid Reaction to Adenosine

Published online by Cambridge University Press:  28 June 2012

John G. Fata ,
Ronald N. Roth  and
Linda Carpenter
John G. Fata
Affiliation:
Clinical Instructor, Department of Medicine, Michigan State University, College of Human Medicine, Lansing, Michigan
Ronald N. Roth*
Affiliation:
Assistant Professor of Medicine, Division of Emergency Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania
Linda Carpenter
Affiliation:
Affiliated Residency in Emergency Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania
*
Division of Emergency Medicine, University of Pittsburgh, School of Medicine, 230 McKee Place, Suite 500, Pittsburgh, PA 15213 USA
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Abstract

Adenosine (Adenocard) is an endogenous purine nucleoside that has been approved recently for intravenous treatment of paroxysmal supraventricular tachycardia. With a serum half-life of 10 seconds, reported side effects including facial flushing, dyspnea, and chest pressure are common, but very transient. An elderly woman who received adenosine for paroxysmal supraventricular tachycardia had a prolonged anaphylactoid reaction that required pharmacological treatment. This is the first reported case of prolonged anaphylactoid reaction to adenosine.

Keywords

adenosineanaphylactoid reactionsupraventricular tachycardiaurticaria

Information

Type
Case Report
Information
Prehospital and Disaster Medicine , Volume 11 , Issue 2 , June 1996 , pp. 144 - 146
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1996

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References

1. Dimarco, JP, Miles, W, Alchter, M, et al. : Adenosine for paroxysmal supraventricular tachycardia: Dose ranging and comparison with verapamil. Ann Intern Med 1990;113:104–110.CrossRefGoogle ScholarPubMed
2. Rankin, AC, Oldroyd, KG, Chens, E, et al. : Adenosine or adenosine triphosphate for supraventricular tachycardia? Comparative double-blind randomized study in patients with spontaneous or inducible arrhythmias. Am Heart J 1990;119:316–323.CrossRefGoogle ScholarPubMed
3. Favale, S, DiBiase, M, Rizzo, U, et al. : Effect of adenosine and adenosine 5 triphosphate on extraventricular conduction in patients. Am J Cardiol 1985;5:1212–1219.CrossRefGoogle Scholar
4. Dimarco, JP, Sellers, TD, Berne, RM, et al. : Adenosine: Electrophysio-logic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia. Circulation 1983;68:1254–1263.Google Scholar
5. Adenosine package insert. Physician's Desk Reference, Medical Economics data, Montvail, N.J., 1992, pp1007–1008.Google Scholar
6. Jeser, A, Oppenheimer, BS, Schwartz, SP: The effect of adenosine on cardiac irregularities in men. Am Heart J 1983;9:252–258.CrossRefGoogle Scholar
7. Belhassen, B, Pelleg, A: Acute management of paroxysmal supraventricular tachycardia: Verapamil, adenosine triphosphate, or adenosine? Am J Cardiol 1984;54:225–227.CrossRefGoogle ScholarPubMed
8. Gamet, L, Linker, N, Griffith, M, et al. : Comparison of adenosine and verapamil in termination of paroxysmal junctional tachycardia. Am J Cardiol 1989;64:1310–1316.Google Scholar
9. Dimarco, JP, Sellers, TD, Lermen, BP, et al. : Diagnostic and therapeutic use of adenosine in patients with supraventricular tachyarrhythmias. J Am Coll Cardiol 1985;6:417–418.CrossRefGoogle ScholarPubMed
10. Rankin, N, Oldroyd, KG, Chong, E, et al. : Value and limitations of adenosine in the diagnosis and treatment of narrow and broad complex tachycardias. Br Heart J 1989;62:195–203.Google Scholar
11. Cushley, MJ, Tattersfield, AE, Holgate, ST: Inhaled adenosine and quanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol 1983;15:161–165.Google Scholar
12. Larsson, IC, Solleri, A: Influence of infused adenosine on bronchial tone and bronchial reactivity in asthma. Chest 1988;93:280–284.CrossRefGoogle ScholarPubMed
13. Bush, A, Busst, CM, Clark, B, et al. : Effect of infused adenosine on cardiac output and systemic vascular resistance in normal subjects. Br J Pharmacol 1989;27:165–171.CrossRefGoogle ScholarPubMed
14. Paumels, RA, Vanderstraeten, ME: An animal model for adenosine-induced bronchoconstriction. Am Rev Respir Dis 1987;131:374–378.CrossRefGoogle Scholar
15. Hughes, PJ, Holgate, ST, Church, MK: Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism. Biochem Pharmacol 1984;33:3847–3852.CrossRefGoogle ScholarPubMed