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Similarities and differences among the Opisthorchiidae liver flukes: insights from Opisthorchis felineus

Published online by Cambridge University Press:  16 May 2022

Maria Y. Pakharukova Open the ORCID record for Maria Y. Pakharukova [Opens in a new window]  and
Viatcheslav A. Mordvinov Open the ORCID record for Viatcheslav A. Mordvinov [Opens in a new window]
Maria Y. Pakharukova
Affiliation:
Laboratory of Molecular Mechanisms of Pathological Processes, Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Akad. Lavrentieva Ave., Novosibirsk 630090, Russia Department of Natural Sciences, Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russia
Viatcheslav A. Mordvinov*
Affiliation:
Laboratory of Molecular Mechanisms of Pathological Processes, Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Akad. Lavrentieva Ave., Novosibirsk 630090, Russia
*
Author for correspondence: Viatcheslav A. Mordvinov, E-mail: mordvin@bionet.nsc.ru
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Abstract

The foodborne liver trematode Opisthorchis felineus (Rivolta, 1884) is a member of the triad of phylogenetically related epidemiologically important Opisthorchiidae trematodes, which also includes O. viverrini (Poirier, 1886) and Clonorchis sinensis (Loos, 1907). Despite similarity in the life cycle, Opisthorchiidae liver flukes also have marked differences. Two species (O. viverrini and C. sinensis) are recognized as Group 1A biological carcinogens, whereas O. felineus belongs to Group 3A. In this review, we focus on these questions: Are there actual differences in carcinogenicity among these 3 liver fluke species? Is there an explanation for these differences? We provide a recent update of our knowledge on the liver fluke O. felineus and highlight its differences from O. viverrini and C. sinensis. In particular, we concentrate on differences in the climate of endemic areas, characteristics of the life cycle, the range of intermediate hosts, genomic and transcriptomic features of the pathogens, and clinical symptoms and morbidity of the infections in humans. The discussion of these questions can stimulate new developments in comparative studies on the pathogenicity of liver flukes and should help to identify species-specific features of opisthorchiasis and clonorchiasis pathogenesis.

Keywords

Cholangiocarcinomafoodborne trematodesliver flukesOpisthorchis felineus

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Type
Review Article
Information
Parasitology , Volume 149 , Special Issue 10: Foodborne Trematodes – time to rise from neglected status , September 2022 , pp. 1306 - 1318
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Copyright © The Author(s), 2022. Published by Cambridge University Press

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