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Assessment of anthelmintic effectiveness to control Fasciola hepatica and paramphistome mixed infection in cattle in the humid tropics of Mexico

Published online by Cambridge University Press:  05 July 2021

Rodrigo Ico-Gómez ,
Roberto González-Garduño Open the ORCID record for Roberto González-Garduño [Opens in a new window] ,
Diego Ortiz-Pérez ,
Juan J. Mosqueda-Gualito Open the ORCID record for Juan J. Mosqueda-Gualito [Opens in a new window] ,
Ever del J. Flores-Santiago ,
Gustavo Sosa-Pérez  and
Abel A. Salazar-Tapia
Rodrigo Ico-Gómez
Affiliation:
Unidad Regional Universitaria Sursureste. Universidad Autónoma Chapingo. Km. 7 Carr. Teapa-V. Guerrero, Teapa, Tabasco, Mexico
Roberto González-Garduño*
Affiliation:
Unidad Regional Universitaria Sursureste. Universidad Autónoma Chapingo. Km. 7 Carr. Teapa-V. Guerrero, Teapa, Tabasco, Mexico
Diego Ortiz-Pérez
Affiliation:
Facultad De Medicina Veterinaria y Zootecnia, Extensión Pichucalco. Universidad Autónoma de Chiapas. Libramiento de la Ciudad, Boulevard Universitario S/N. Col. Napaná, Pichucalco, Chiapas, Mexico
Juan J. Mosqueda-Gualito
Affiliation:
Laboratorio de Inmunología y Vacunas. Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro, Qro, Mexico
Ever del J. Flores-Santiago
Affiliation:
Unidad Regional Universitaria Sursureste. Universidad Autónoma Chapingo. Km. 7 Carr. Teapa-V. Guerrero, Teapa, Tabasco, Mexico
Gustavo Sosa-Pérez
Affiliation:
Unidad Regional Universitaria Sursureste. Universidad Autónoma Chapingo. Km. 7 Carr. Teapa-V. Guerrero, Teapa, Tabasco, Mexico
Abel A. Salazar-Tapia
Affiliation:
División Académica de Ciencias Agropecuarias. Universidad Juárez Autónoma de Tabasco. Carretera Villahermosa-Teapa, km 25, Villahermosa, Tabasco, Mexico
*
Author for correspondence: Roberto González-Garduño, E-mail: rgonzalezg@chapingo.mx
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Abstract

The objective of this study was to evaluate the effectiveness of the main anthelmintics used for the control of trematodes in cattle in an endemic area in the humid Mexican tropics. A diagnostic study was carried out in nine cattle farms to determine the prevalence of flukes through faecal examination. Only three farms with more than 20 cows positive to trematodes were chosen to determine the effectiveness of commercial anthelmintics (triclabendazole, TCBZ; ivermectin + closantel, (IVM + CLOS); IVM + clorsulon, (CLORS); nitroxynil, NITROX). The prevalence of Fasciola hepatica was 27.1% and 29.6% of paramphistomes. The faecal egg count of trematodes ranged from 0.0 to 12.2 eggs per gram of faeces. The highest effectiveness against F. hepatica was 96.7%, and 92.7% against paramphistomes. NITROX was the most effective in the control of trematodes, while other products, such as IVM + CLORS and TCBZ obtained values lower than 90%, which puts sustainable trematode control at risk. The presence of trematodes was observed on most farms, although the prevalence per herd was highly variable, which indicates that the trematodes F. hepatica and paramphistomes are endemic to the region and a suitable management programme is suggested to control infections caused by these parasites.

Keywords

Anthelmintic resistancecattlegastrointestinal parasitestrematodes

Information

Type
Research Article
Information
Parasitology , Volume 148 , Issue 12 , October 2021 , pp. 1458 - 1466
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Copyright © The Author(s), 2021. Published by Cambridge University Press

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References

Aktaruzzaman, M, Mohamed, Z, -Ul-Alam, N, Islam, MS and Howlader, MMR (2015) Evaluation of anthelmintic efficacy of triclabendazole, nitroxynil and albendazole against naturally acquired fascioliasis in cattle of Bangladesh with special reference to its residual effect. International Journal of Pharmacology and Toxicology 3, 1.CrossRefGoogle Scholar
Arias-García, R, Vera-Montenegro, Y, Flores-Ramos, M, Castillo, R, Hernández-Campos, A and Ibarra-Velarde, F (2020) Efficiency comparison of experimental fosfatriclaben with three commercial fasciolicides in experimentally infected sheep. Parasitology Research 119, 2687–2693.CrossRefGoogle ScholarPubMed
Arias, M, Lomba, C, Dacal, V, Vázquez, L, Pedreira, J, Francisco, I, Piñeiro, P, Cazapal-Monteiro, C, Suárez, J, Díez-Baños, P, Morrondo, P, Sánchez-Andrade, R and Paz-Silva, A (2011) Prevalence of mixed trematode infections in an abattoir receiving cattle from northern Portugal and north-west Spain. Veterinary Record 168, 408.CrossRefGoogle Scholar
Arias, MSS, Sanchís, M, Francisco, I, Francisco, R, Piñeiro, P, Cazapal-Monteiro, C, Cortiñas, F, Suárez, J, Sánchez-Andrade, R, Paz-Silva, A, Sanchis, J, Francisco, I, Francisco, R, Pineiro, P, Cazapal-Monteiro, C, Cortinas, F, Suarez, J, Sanchez-Andrade, R and Paz-Silva, A (2013) The efficacy of four anthelmintics against Calicophoron daubneyi in naturally infected dairy cattle. Veterinary Parasitology 197, 126–129.CrossRefGoogle ScholarPubMed
Brockwell, YM, Elliott, TP, Anderson, GR, Stanton, R, Spithill, TW and Sangster, NC (2014) Confirmation of Fasciola hepatica resistant to triclabendazole in naturally infected Australian beef and dairy cattle. International Journal for Parasitology: Drugs and Drug Resistance 4, 48–54.Google ScholarPubMed
CONAGUA (2021) Servicio Meteorológico Nacional. Normales climatológicas. Available at http://smn.cna.gob.mx/climatologia/normales/estacion/tab/NORMAL27068.TXT.Google Scholar
Dobson, RJ, Hosking, BC, Jacobson, CL, Cotter, JL, Besier, RB, Stein, PA and Reid, SA (2012) Preserving new anthelmintics: a simple method for estimating faecal egg count reduction test (FECRT) confidence limits when efficacy and / or nematode aggregation is high. Veterinary Parasitology 186, 79–92.CrossRefGoogle ScholarPubMed
Dorny, P, Stoliaroff, V, Charlier, J, Meas, S, Sorn, S, Chea, B, Holl, D, Van Aken, D and Vercruysse, J (2011) Infections with gastrointestinal nematodes, Fasciola and Paramphistomum in cattle in Cambodia and their association with morbidity parameters. Veterinary Parasitology 175, 293–299.CrossRefGoogle ScholarPubMed
Eduardo, SL (1982) The taxonomy of the family Paramphistomidae Fischoeder, 1901 with special reference to the morphology of species occurring in ruminants. I. General considerations. Systematic Parasitology 4, 7–57.CrossRefGoogle Scholar
Elelu, N and Eisler, MC (2017) A review of bovine fasciolosis and other trematode infections in Nigeria. Journal of Helminthology 92, 128–141.CrossRefGoogle ScholarPubMed
Fairweather, I, Brennan, GP, Hanna, REB, Robinson, MW and Skuce, PJ (2020) Drug resistance in liver flukes. International Journal for Parasitology: Drugs and Drug Resistance 12, 39–59.Google ScholarPubMed
Ferreras, MC, González-Lanza, C, Pérez, V, Fuertes, M, Benavides, J, Mezo, M, González-Warleta, M, Giráldez, J, Martínez-Ibeas, AM, Delgado, L, Fernández, M and Manga-González, MY (2014) Calicophoron daubneyi (Paramphistomidae) in slaughtered cattle in Castilla y León (Spain). Veterinary Parasitology 199, 268–271.CrossRefGoogle Scholar
Fetterer, RH, Rew, RS, Gasbarre, LC and Ostlind, DA (1985) Prophylactic efficacy of clorsulon against Fasciola hepatica in calves and sheep. Veterinary Parasitology 18, 21–27.CrossRefGoogle ScholarPubMed
Forbes, A (2016) The biology of fluke and their control in cattle. Livestock 21, 30–35.CrossRefGoogle Scholar
Geurden, T, Bartram, D, Van Brussel, L, Bo, L, Scott-Baird, E and Rugg, D (2012) Evaluation of the comparative efficacy of a moxidectin plus triclabendazole pour-on solution against adult and immature liver fluke, Fasciola hepatica, in cattle. Veterinary Parasitology 189, 227–232.CrossRefGoogle ScholarPubMed
Giraldo Forero, JC, Díaz Anaya, AM and Pulido Medellín, MO (2016) Prevalencia de Fasciola hepatica en bovinos sacrificados en la planta de beneficio del municipio de Une, Cundinamarca, Colombia. Revista de Investigaciones Veterinarias del Perú 27, 751–757.CrossRefGoogle Scholar
González-Garduño, R, Ortiz-Pérez, DO, Alegría-Jiménez, L, Torres-Chable, OM, Cruz-Tamayo, AA and Zaragoza-Vera, CV (2020) Evaluation of anthelmintic drugs against egg development of rumen flukes recovered from cattle raised in the humid tropics of Mexico. Journal of Helminthology 4, 1–7.Google Scholar
Islam, A (2013) Comparative efficacy of ivermectin plus clorsulon and nitroxynil against naturally infected cattle. Eurasian Journal of Veterinary Sciences 29, 43–45, Available at http://eurasianjvetsci.org/pdf/pdf.Google Scholar
Jones, A (1990) Techniques for hand-sectioning thick-bodied platyhelminths. Systematic Parasitology 15, 211–218.CrossRefGoogle Scholar
Jones, RA, Brophy, PM, Mitchell, ES and Williams, HW (2017) Rumen fluke (Calicophoron daubneyi) on Welsh farms: prevalence, risk factors and observations on co-infection with Fasciola hepatica. Parasitology 144, 237–247.CrossRefGoogle ScholarPubMed
Kelley, JM, Elliott, TP, Beddoe, T, Anderson, G, Skuce, P and Spithill, TW (2016) Current threat of triclabendazole resistance in Fasciola hepatica. Trends in Parasitology 32, 458–469.CrossRefGoogle ScholarPubMed
Kelley, JM, Rathinasamy, V, Elliott, TP, Rawlin, G, Beddoe, T, Stevenson, MA and Spithill, TW (2020) Determination of the prevalence and intensity of Fasciola hepatica infection in dairy cattle from six irrigation regions of Victoria, South-eastern Australia, further identifying significant triclabendazole resistance on three properties. Veterinary Parasitology 277, 109019.CrossRefGoogle ScholarPubMed
Malrait, K, Verschave, S, Skuce, P, Van Loo, H, Vercruysse, J and Charlier, J (2015) Novel insights into the pathogenic importance, diagnosis and treatment of the rumen fluke (Calicophoron daubneyi) in cattle. Veterinary Parasitology 207, 134–139.CrossRefGoogle ScholarPubMed
Meaney, M, Fairweather, I, Brennan, GP, McDowell, LSL and Forbes, AB (2003) Fasciola hepatica: effects of the fasciolicide clorsulon in vitro and in vivo on the tegumental surface, and a comparison of the effects on young-and old-mature flukes. Parasitology research 91, 238–250.CrossRefGoogle Scholar
Merachew, W and Alemneh, T (2020) Review on triclabendazole resistance in Fasciola. Journal of Veterinary Science & Medicine 8, 1–8.Google Scholar
Naranjo-Lucena, A, Munita Corbalán, MP, Martínez-Ibeas, AM, McGrath, G, Murray, G, Casey, M, Good, B, Sayers, R, Mulcahy, G and Zintl, A (2018) Spatial patterns of Fasciola hepatica and Calicophoron daubneyi infections in ruminants in Ireland and modelling of C. daubneyi infection. Parasites & Vectors 11, 1–13.CrossRefGoogle ScholarPubMed
Novobilský, A and Höglund, J (2015) First report of closantel treatment failure against Fasciola hepatica in cattle. International Journal for Parasitology: Drugs and Drug Resistance 5, 172–177.Google ScholarPubMed
Novobilský, A, Amaya Solis, N, Skarin, M and Höglund, J (2016) Assessment of flukicide efficacy against Fasciola hepatica in sheep in Sweden in the absence of a standardised test. International Journal for Parasitology: Drugs and Drug Resistance 6, 141–147.Google ScholarPubMed
Nurhidayah, N, Satrija, F, Satrija, F, Retnani, EB, Retnani, EB, Astuti, DA, Murtini, S and Murtini, S (2020) Prevalence and risk factors of trematode infection in swamp buffaloes reared under different agro-climatic conditions in Java island of Indonesia. Veterinary World 13, 687–694.CrossRefGoogle Scholar
Nzalawahe, J, Hannah, R, Kassuku, AA, Stothard, JR, Coles, G and Eisler, MC (2018) Evaluating the effectiveness of trematocides against Fasciola gigantica and amphistomes infections in cattle, using faecal egg count reduction tests in Iringa Rural and Arumeru Districts, Tanzania. Parasites & vectors 11, 1–9.CrossRefGoogle ScholarPubMed
Ojeda-Robertos, NF, González-Garduño, R, Cornelio-Cruz, S, Peralta-Torres, JA, Luna-Palomera, C, Machain-Williams, C, Zarza, H, Torres-Chablé, OM, Reyes-Novelo, E, Baak-Baak, C and Chay-Canul, A (2020) Factores asociados al decomiso de hígados positivos a Fasciola sp en una zona endémica del sureste de México. Revista Mexicana De Ciencias Pecuarias 11, 565–575.CrossRefGoogle Scholar
Paucar, S, Chávez, A, Casas, E and Suárez, F (2010) Prevalencia de fascioliasis y paramfistomiasis en el ganado lechero de Oxapampa, Pasco. Revista de Investigaciones Veterinarias del Perú 21, 87–92.Google Scholar
Pinedo, V, Chávez, V, Casas, A, Suárez, A, Sánchez, P and Huamán, U (2010) Prevalencia de trematodes de la familia Paramphistomatidae en bovinos del distrito de Yurimaguas, provincia de alto Amazonas. Revista de Investigaciones Veterinarias del Perú 21, 161–167.Google Scholar
Pinilla, JC, Florez Muñoz, AA and Uribe Delgado, N (2020) Prevalence and risk factors associated with liver fluke Fasciola hepatica in cattle and sheep in three municipalities in the Colombian Northeastern Mountains. Veterinary Parasitology: Regional Studies and Reports 19, 100364.Google ScholarPubMed
Rojas-Campos, T, Vera-Montenegro, Y, Flores-Ramos, M, Castillo, R, Hernández-Campos, A and Ibarra-Velarde, F (2019) Effectiveness of the experimental Fosfatriclaben in comparison with two commercial Fasciolicides in Cattle. Pharmacology & Pharmacy 10, 498–506.CrossRefGoogle Scholar
Rolfe, PF and Boray, JC (1987) Chemotherapy of paramphistomosis in cattle. Australian Veterinary Journal 64, 328–332.CrossRefGoogle ScholarPubMed
Romero, J, Villaguala, C, Quiroz, F, Landaeta-Aqueveque, C, Alfaro, G and Pérez, R (2019) Flukicide efficacy against Fasciola hepatica of Triclabendazole and Nitroxynil in cattle of the central valley of Chile. Revista Brasileira de Parasitologia Veterinária 28, 164–167.CrossRefGoogle ScholarPubMed
Sanabria, REF and Romero, JR (2008) Review and update of paramphistomosis. Helminthologia 45, 64–68.CrossRefGoogle Scholar
Sanchís, J, Sánchez-Andrade, R, Macchi, MI, Piñeiro, P, Suárez, JL, Cazapal-Monteiro, C and Arias, MS (2013) Infection by paramphistomidae trematodes in cattle from two agricultural regions in NW Uruguay and NW Spain. Veterinary Parasitology 191, 165–171.CrossRefGoogle ScholarPubMed
Sargison, N, Francis, E, Davison, C, Bronsvoort, BMDC, Handel, I and Mazeri, S (2016) Observations on the biology, epidemiology and economic relevance of rumen flukes (paramphistomidae) in cattle kept in a temperate environment. Veterinary Parasitology 219, 7–16.CrossRefGoogle Scholar
Shokier, KM, Aboelhadid, SM and Waleed, MA (2013) Efficacy of five anthelmintics against a natural Fasciola species infection in cattle. Beni-Suef University Journal of Basic and Applied Sciences 2, 41–45.CrossRefGoogle Scholar
Torgerson, PR (2013) Veterinary parasitology one world health: socioeconomic burden and parasitic disease control priorities. Veterinary Parasitology 195, 223–232.CrossRefGoogle ScholarPubMed
Villa-Mancera, A and Reynoso-Palomar, A (2019) High prevalence, potential economic impact, and risk factors of Fasciola hepatica in dairy herds in tropical, dry and temperate climate regions in Mexico. Acta Tropica 193, 169–175.CrossRefGoogle ScholarPubMed