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Production and Characterization of Large Porous Particles for Pulmonary Drug Delivery

Published online by Cambridge University Press:  15 February 2011

Rick Batycky ,
Jackie Nice ,
Donghao Chen ,
Jean Sung ,
Mike Lipp ,
Jeff Mintzes ,
Craig Dunbar ,
Ralph Niven  and
David Edwards
Rick Batycky
Affiliation:
Advanced Inhalation Research (AIR) 840 Memorial Drive Cambridge, MA 02139
Jackie Nice
Affiliation:
Advanced Inhalation Research (AIR) 840 Memorial Drive Cambridge, MA 02139
Donghao Chen
Affiliation:
Advanced Inhalation Research (AIR) 840 Memorial Drive Cambridge, MA 02139
Jean Sung
Affiliation:
Advanced Inhalation Research (AIR) 840 Memorial Drive Cambridge, MA 02139
Mike Lipp
Affiliation:
Advanced Inhalation Research (AIR) 840 Memorial Drive Cambridge, MA 02139
Jeff Mintzes
Affiliation:
Advanced Inhalation Research (AIR) 840 Memorial Drive Cambridge, MA 02139
Craig Dunbar
Affiliation:
Advanced Inhalation Research (AIR) 840 Memorial Drive Cambridge, MA 02139
Ralph Niven
Affiliation:
Advanced Inhalation Research (AIR) 840 Memorial Drive Cambridge, MA 02139
David Edwards
Affiliation:
Advanced Inhalation Research (AIR) 840 Memorial Drive Cambridge, MA 02139
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Abstract

Inhalation of dry powders comprised of large porous particles appears to promote long therapeutic action and increased systemic bioavailability (1-3). Relative to standard inhalation aerosols, dry powders possessing large porous particles clear relatively slowly from the lungs once inhaled (1) and show less aggregation prior to delivery. The diminished aggregation properties of large porous particles permits their use in a simple (and inexpensive) device without the need for carrier particles.

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References

1) Large porous particles for pulmonary drug delivery. Edwards, D.A.; Hanes, J.; Caponetti, G.; Hrkach, J.S.; Ben-Jebria, A.; Eskew, M.L.; Mintzes, J.; Deaver, D.; Lotan, N.; Langer, R., Science 1997, 276, 1868–1871.Google Scholar
2) Controlled Release Inhalation Aerosols; Edwards, D. A., Chen, D., Wang, J., Ben-Jebria, A.; Resp. Drug Del. VI, Hilton Head, SC, 187–192, (1998).Google Scholar
3) Recent advances in pulmonary drug delivery using large, porous inhaled particles; Edwards, D.A., Ben-Jebria, A., Langer, R.; J. Appl. Physiol. 84 (2) 379–385, (1998).Google Scholar