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A Novel Surface Topographical Concept for BoneImplant

Published online by Cambridge University Press:  28 January 2011

G. Munir ,
L. Di Silvio ,
M.J. Edirisinghe ,
W. Bonfield  and
J. Huang
G. Munir
Affiliation:
Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.
L. Di Silvio
Affiliation:
Biomaterials, Biomimetics and Biophotonics, King’s College Dental Institute at Guy’s, King’s and St. Thomas’ Hospitals, Floor 17, Guy’s Tower, London SE1 9RT, U.K.
M.J. Edirisinghe
Affiliation:
Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.
W. Bonfield
Affiliation:
Department of Materials Science and Metallurgy, University of Cambridge, Pembroke Street Cambridge B2 QZ U.K.
J. Huang
Affiliation:
Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.
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Abstract

Template-assisted electrohydrodynamic atomization (TAEA) sprayingdeposition, a recently developed and an electric-driven jet-based techniquehas been used to prepare bioactive surface topography on titanium (Ti).Nanometer-scaled SiHA (nanoSiHA), which closely resembles the bone mineral,has been synthesized and deposited on Ti surfaces with a range of patterns,such as pillars and tracks. A human osteoblast (HOB) cell model has beenused to evaluate the in vitro cellular responses to nanoSiHA deposition.alamarBlue™ assay showed that nanoSiHA patterns are able to encourage theattachment and growth of HOB cells in comparison to those of nanoSiHAcoating. The preferential growth of HOB cells was found along and across thetrack, HOB cells were also found to stretch between two tracks. Imageanalysis of HOB cell responses to the size of nanoSiHA pattern showed thatthe length of HOB cells was proportional to the gaps between the tracksuntil reaching the maximum length of 110 μm. The results indicate that thedistance between the structures is paramount over the width. Our study willpave the way to control and guide cellular responses for new generation ofbone implants.

Keywords

biomaterialsolution depositionsurface chemistry

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References

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