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Multifunctional Nanoparticles for Targeted Imaging and Therapy of Cancer

Published online by Cambridge University Press:  01 February 2011

Yong-Eun Koo Lee  and
Raoul Kopelman
Yong-Eun Koo Lee
Affiliation:
yeleekoo@umich.edu, University of Michigan, Ann Arbor, Michigan, United States
Raoul Kopelman
Affiliation:
kopelman@umich.edu
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Abstract

The idea of making biocompatible multifunctional nanoparticles, combining therapy, imaging and targeting, was aimed at cancer from the start a dozen years ago. This presentation will emphasize targeted theranostic nanoparticles, where “theranostic” literally means combining therapy and diagnostics, but more generally may mean a combination of imaging/visualization with therapy/surgery. Specific examples will cover (1) imaging (MRI, CT and optical methods), (2) therapy (chemo, photodynamic, radiation) and (3) guided surgery (using intra-operative imaging and therapy). Progress on brain and on head and neck cancer will be reported.

Keywords

biomedicalnanostructurebiomaterial

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