Hostname: page-component-54dcc4c588-trf7k Total loading time: 0 Render date: 2025-10-12T01:57:46.292Z Has data issue: false hasContentIssue false
  • English
  • Français

Bioresorbable Microspheres as Injectable Cell Carrier: FRom Preparation to in Vitro Evaluation

Published online by Cambridge University Press:  15 February 2011

Y. Senuma ,
S. Franceschin ,
J. G. Hilborn ,
P. Tissiéres  and
P. Frey
Y. Senuma
Affiliation:
Polymer Laboratory, Department of Materials Science, Swiss Federal Institute of Technology Lausanne, CH-1015 Ecublens, Switzerland, Joens.Hilbom@epfl.ch
S. Franceschin
Affiliation:
Polymer Laboratory, Department of Materials Science, Swiss Federal Institute of Technology Lausanne, CH-1015 Ecublens, Switzerland, Joens.Hilbom@epfl.ch
J. G. Hilborn
Affiliation:
Polymer Laboratory, Department of Materials Science, Swiss Federal Institute of Technology Lausanne, CH-1015 Ecublens, Switzerland, Joens.Hilbom@epfl.ch
P. Tissiéres
Affiliation:
Pediatric Surgery, Centre Hospitalier du Canton de Vaud, Switzerland
P. Frey
Affiliation:
Pediatric Surgery, Centre Hospitalier du Canton de Vaud, Switzerland
Get access

Abstract

A new approach to the vesico-ureteral reflux could be a local regeneration of the defective vesicoureteral junction by transplanting living cells to the target site. The aim of this work is to provide a long-term effective treatment by producing bioresorbable microspheres which can act as support matrix for those cells, with the goal of an in vivo transfer of the in vitro cultured cells with a minimal surgical procedure. After microsphere degradation, the cells should be integrated into the muscular structure of the junction. Most innovative is that these are cultured muscle and urothelial cells from the bladder of the same patient.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1. Bailey, R.R., Kidney International 44, 80–85 (1993).Google Scholar
2. Bomalaski, M.D., Hirschl, B.R., and Bloom, A.D., The Journal of Urology 157, 969–974 (1997).Google Scholar
3. Frey, P., Lutz, N., Jenny, P., and Herzog, B., The Journal of Urology 154, 804–807 (1995).Google Scholar
4. Frey, P., Gudinchet, F., and Jenny, P., The Journal of Urology 158, 12 10–1212 (1997).Google Scholar
5. Langer, R. and Vacanti, J.P., Science 260, 920–926 (1993).Google Scholar
6. Baskin, L.S., Howard, P.S., Duckett, J.W., Snyder, H.M., and Macarak, E.J., The Journal of Urology 149, 190–197 (1993).Google Scholar
7. Sittinger, M., Bujia, J., Rotter, N., Reitzel, D., Minuth, W.W., and Burmester, G.R., Biomaterials 17, 237–242 (1996).Google Scholar
8. Black, J., Biological Performance of Materials:fundamentals ofbiocompatibility, ed. (CRC PRESS, 1990)Google Scholar
9. Atala, A., Freeman, M.R., Vacanti, J.P., Shepard, J., and Retik, A.B., The Journal of Urology 150, 608–612 (1993).Google Scholar
10. Senuma, Y. and Hilborn, J.G. (submitted).Google Scholar