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Biological Modification in the Brushite Crystallization

Published online by Cambridge University Press:  17 March 2011

Ruikang Tang ,
Molly R. Darragh ,
Christine A. Orme ,
John R. Hoyer  and
George H. Nancollas
Ruikang Tang
Affiliation:
Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
Molly R. Darragh
Affiliation:
Department of Chemistry and Materials Science, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
Christine A. Orme
Affiliation:
Department of Chemistry and Materials Science, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA
John R. Hoyer
Affiliation:
The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
George H. Nancollas
Affiliation:
Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
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Abstract

The crystallization of brushite has been investigated in the presence of typical ionic biological components, magnesium, fluoride and citrate and a natural protein, osteopontin, using a constant composition method capable of nano-mole sensitivity. While the simple ionic additives, magnesium and fluoride do not have a significant effect, citrate ions can adsorb on lateral faces due to electrostatic interactions involving the functional carboxylate groups, resulting in crystal morphology changes. Osteopontin was the most effective inhibitor influencing the growth of virtually all brushite crystal faces.

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Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 823: Symposium W – Biological and Bioinspired Materials and Devices , 2004 , W7.2
Copyright
Copyright © Materials Research Society 2004

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