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Synthesis and Characterization of Water Soluble Block Copolymers for pH-Sensitive Delivery

Published online by Cambridge University Press:  15 March 2011

Brian C. Anderson ,
Paul D. Bloom ,
Valerie V. Sheares  and
Surya K. Mallapragada
Brian C. Anderson
Affiliation:
Department of Chemical Engineering, Iowa State University, 2114 Sweeney Hall, Ames, Iowa, 50011 Ames Laboratory, Department of Energy, Iowa State University, Ames, Iowa, 50011
Paul D. Bloom
Affiliation:
Department of Chemistry, Iowa State University, 2760 Gilman Hall, Ames, Iowa, 50011 Ames Laboratory, Department of Energy, Iowa State University, Ames, Iowa, 50011
Valerie V. Sheares
Affiliation:
Department of Chemistry, Iowa State University, 2760 Gilman Hall, Ames, Iowa, 50011 Ames Laboratory, Department of Energy, Iowa State University, Ames, Iowa, 50011
Surya K. Mallapragada
Affiliation:
Department of Chemical Engineering, Iowa State University, 2114 Sweeney Hall, Ames, Iowa, 50011 Ames Laboratory, Department of Energy, Iowa State University, Ames, Iowa, 50011
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Abstract

A novel, water-soluble AB-block copolymer of diethylaminoethyl methacrylate (DEAEM) and poly(ethylene glycol) (PEG) was synthesized by anionic polymerization. Poly(ethylene glycol) methyl ether (PEGME) was converted into the corresponding potassium salt by reacting with potassium metal. The PEG salt was used as a macroinitiator for the polymerization of DEAEM to yield a PEG-b-PDEAEM block copolymer. Carbon dioxide was used to terminate DEAEM polymerization with a carboxylic acid group. This polymer, loaded with dye, was tested for pH sensitivity by release studies into solutions of various pH.

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