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Preparation and Surface Modification of Rare-Earth Doped Ceramic Nano-Phosphors for Fluorescence Bioimaging

Published online by Cambridge University Press:  01 February 2011

Kohei Soga ,
Yu Saito ,
Kazuaki Shimizu ,
Hiroyasu Nagata ,
Tomoya Konishi  and
Yukio Nagasaki
Kohei Soga
Affiliation:
mail@ksoga.com, Tokyo University of Science, Dept. Materials Sci. and Tech., 2641 Yamazaki, Noda, 278-8510, Japan, +81-4-7122-9689, +81-4-7124-1526
Yu Saito
Affiliation:
luv-sick1118@sogalabo.jp, Tokyo University of Science, Dept. Materials Sci. and Tech., 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Kazuaki Shimizu
Affiliation:
kazu@sogalabo.jp, Tokyo University of Science, Dept. Materials Sci. and Tech., 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Hiroyasu Nagata
Affiliation:
h-nagata@sogalabo.jp, Tokyo University of Science, Dept. Materials Sci. and Tech., 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Tomoya Konishi
Affiliation:
kon@sogalabo.jp, Tokyo University of Science, Dept. Materials Sci. and Tech., 2641 Yamazaki, Noda, Chiba, 278-8510, Japan
Yukio Nagasaki
Affiliation:
nagasaki@nagalabo.jp, University of Tsukuba, TIMS, 1-1-1 Tennoudai, Tukuba, Ibaraki, 305-8573, Japan
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Abstract

Rare-earth doped yttrium oxide nano-particles modified with bio functional polymers are one of the good candidate for upconversion bio imager. The requirement to the particles for bio imaging application is a small particle size less than 50 nm, dispersion and chemical durability in body fluid. In this study, polyacrylic acid (PAAc) was used for both precursor precipitation and surface modification of the calcinated particles. The use of the PAAc resulted in small particle size at 33 nm. Also, the modification by adding 104 PAAc/particle resulted in chemical durability and dispersion of the particles under heavily acidic and basic conditions.

Keywords

surface chemistryoxideY

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References

REFERENCES

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