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Synthesis of gold nanoparticles specific to pH- and salt- tolerancefor biomedical applications

Published online by Cambridge University Press:  22 February 2016

Prem C. Pandey  and
Govind Pandey
Prem C. Pandey*
Affiliation:
Department of Chemistry, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, India
Govind Pandey
Affiliation:
Department of Pharmacology, BRD Medical College, Gorakhpur-273013, India
*
*(Email: pcpandey.apc@itbhu.ac.in)
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Abstract

The synthesis of gold nanoparticles (AuNPs) displaying pH and salt resistantactivity has been a challenging tasks. The use of aminopropyltrimethoxysilane(3-APTMS) as one of the reagent during the synthesis of AuNPs may control suchactivity due to its micellar behavior. The AuNPs made from 3-APTMS capped goldions in the presence of formaldehyde are found insensitive to pH- and salt. Themajor findings on 3-APTMS and formaldehyde mediated synthesis of AuNPs revealthe following: (1) 3-APTMS being amphiphilic, dispersibility of as preparedAuNPs largely depends on the organic reducing agents. (2) An increase in thehydrocarbon content of the reducing agent facilitate the dispersibility of AuNPsin organic solvent whereas decrease of the same increases the dispersibility inwater, (3) AuNPs made through aldehydic reducing agents (formaldehyde andacetaldehyde) have relatively better salt and pH tolerance as compared toketonic reducing agents (acetone, t-butyl dimethyl ketone), and (4) an increasein 3-APTMS concentrations enables salt- and pH- resistant property to AuNPsirrespective of organic reducing agents.

Keywords

Autransmission electron microscopy (TEM)nanostructure

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Type
Articles
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MRS Advances , Volume 1 , Issue 11: Nanomaterials and Synthesis , 2016 , pp. 729 - 735
Copyright
Copyright © Materials Research Society 2016 

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