Medusozoa comprise a diverse group of marine invertebrates that includes cubozoans, hydrozoans, staurozoans, and scyphozoans, which play a fundamental role in marine ecosystems. In Cuba, with exceptions, most of the studies of the phylum Cnidaria have focused on the scleractinian corals. However, their close relatives, the jellyfish have been poorly addressed, limiting themselves to isolated records of some species. In this study, we aimed to update the list of medusozoan species registered in Cuba and compare it with the registries in the Greater Caribbean region. Peer-reviewed publications, museum collections, field-trips, global repositories, and social networks were accomplished to compile a species list. Twenty-one new species are recorded, and the distribution of 11 species previously reported is expanded. Cuba, with 361 species is the country with the highest species richness in the Caribbean region: 342 species of Hydrozoa are distributed in 69 families, 16 species of Scyphozoa are distributed in 10 families, and three species of Cubozoa each belong to one family. Analysing the studies of Medusozoa reveals significant heterogeneity in jellyfish species composition across the Caribbean region, where Cuba, Puerto Rico, Mexico, and the USA are the countries with the highest species richness. A high similarity was observed between the assemblages from Cuba and the USA. The number of jellyfish species reported for Cuba constitutes a baseline for ecological studies of their integrated role in marine ecosystems. Studies in the Caribbean region are heterogeneous, with an imbalance in the sampling effort in time and space and probably underestimate the number of species known.