Hostname: page-component-cb9f654ff-5kfdg Total loading time: 0 Render date: 2025-08-20T16:07:48.857Z Has data issue: false hasContentIssue false
  • English
  • Français

Language localization, the developing brain and childhood epilepsy: Back to the future

Published online by Cambridge University Press:  20 March 2007

MICHAEL DUCHOWNY
MICHAEL DUCHOWNY
Affiliation:
Comprehensive Epilepsy Program and Brain Institute, Miami Children's Hospital, Miami, Florida Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida
Get access Rights & Permissions [Opens in a new window]

Extract

The defining role of language for communicating and forming social bonds has captured the imagination of scientists and scholars throughout the ages, and scientific inquiry into the neural correlates of language is now centuries old. Theories of linguistic structure and function occupy center stage in fields as diverse as neuroscience, embryology, anthropology and evolution. This should come as no surprise as the neural basis of linguistic function holds promise for understanding how the mind works and what makes us uniquely human.

Information

Type
NEUROBEHAVIORAL GRAND ROUNDS – INTRODUCTION
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 3 , May 2007 , pp. 501 - 504
Copyright
© 2007 The International Neuropsychological Society

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

REFERENCES

Ahmad, B.S., Balsamo, L.M., Sachs, B.C., Xu, B., & Gaillard, W.D. (2003). Auditory comprehension of language in young children. Neurology, 60, 1598–1605.Google Scholar
Balsamo, L.M., Xu, B., Grandin, C.B., Petrella, J.R., Braniecki, S.H., Elliott, T.K., & Gaillard, W.D. (2002). A functional magnetic resonance imaging study of left hemisphere language dominance in children. Archives of Neurology, 59, 1168–1174.Google Scholar
Bell, B., Hermann, B., Seidenberg, M., Davies, K., Cariski, D., Rosenbek, J., Woodard, A., Rutecki, P., & Bishop, M. (2002). Ipsilateral reorganization of language in early-onset left temporal lobe epilepsy. Epilepsy & Behavior, 3, 158–164.Google Scholar
Briellmann, R.S., Labate, A., Harvey, A.S., Saling, M.M., Sveller, C., Lillywhite, W., Abbott, D.F., & Jackson, G.D. (2006). Is language lateralization in temporal lobe epilepsy patients related to the nature of the epileptogenic lesion? Epilepsia, 47, 916–920.Google Scholar
Burneo, J.G., Kuzniecky, R.I., Bebin, M., & Knowlton, R.C. (2004). Cortical reorganization in malformations of cortical development. Neurology, 63, 1818–1824.Google Scholar
Devinsky, O., Perrine, K., Llinas, R., Luciano, D.J., & Dogali, M. (1993). Anterior temporal language areas in patients with early onset of temporal lobe epilepsy. Annals of Neurology, 34, 727–732.Google Scholar
Duchowny, M. (1999). Pediatric epilepsy surgery: The widening spectrum of surgical candidacy. Epileptic Disorders, 1, 143–151.Google Scholar
Duchowny, M.S., Jayakar, P., Harvey, A.S., Resnick, T., Alvarez, L., Dean, P., & Levin, B. (1996). Language cortex representation: Effects of developmental versus acquired pathology. Annals of Neurology, 40, 31–39.Google Scholar
Gaillard, W.D., Balsamo, M.A., Ibrahim, B.A., Sachs, B.C., & Xu, B. (2003). fMRI identifies regional specialization of neural networks for reading in young children. Neurology, 60, 94–100.Google Scholar
Hertz-Pannier, L., Chiron, C., Jambaque, I., Renaux-Kieffer, V., Van de Moortele, P.F., Delalande, O., Fohlen, M., Brunelle, F., & Le Bihan, D. (2002). Late plasticity for language in a child's nondominant hemisphere: A pre- and post-surgery fMRI study. Brain, 125, 361–372.Google Scholar
Janszky, J., Ebner, A., Kruse, B., Mertens, M., Jokeit, H., Seitz, R.J., Witte, O.W., Tuxhorn, I., & Woermann, F.G. (2003). Functional organization of the brain with malformations of cortical development. Annals of Neurology, 53, 759–767.Google Scholar
Jayakar, P. & Duchowny, M. (1993). Functional cortical mapping in children. In O. Devinsky, A. Beric, & M. Dogali (Eds.), Electrical and Magnetic Stimulation of the Brain and Spinal Cord (pp. 149–154). New York: Raven Press.
Johnson, M.H. (2001). Functional brain development in humans. Nature Reviews Neuroscience, 2, 475–483.Google Scholar
Kadis, D.S., Iida, K., Kerr, E.N., Logan, W.J., McAndrews, M.P., Ochi, A., Otsubo, H., Rutka, J.T., Snead III, O.C., Weiss, S.K., & Smith, M.L. (2007, this issue). Intrahemispheric reorganization of language in children with medically intractable epilepsy of the left hemisphere. Journal of the International Neuropsychological Society, 13, 505–516.Google Scholar
Liegeois, F., Connelly, A., Cross, J.H., Boyd, S.G., Gadian, D.G., Vargha-Khadem, F., & Baldeweg, T. (2004). Language reorganization in children with early-onset lesions of the left hemisphere: An fMRI study. Brain, 127, 1229–1236.Google Scholar
Maegaki, Y., Yamamoto, T., & Takeshita, K. (1995). Plasticity of central motor and sensory pathways in a case of unilateral extensive cortical dysplasia. Neurology, 45, 2255–2261.Google Scholar
Marusic, P., Najm, I.M., Ying, Z., Prayson, R., Rona, S., Nair, D., Hadar, E., Kotagal, P., Bej, M.D., Wyllie, E., Bingaman, W., & Luders, H. (2002). Focal cortical dysplasias in eloquent cortex: Functional characteristics and correlation with MRI and histopathologic changes. Epilepsia, 43, 27–32.Google Scholar
Ojemann, G.A. (1983). Brain organization for language from the perspective of electrical stimulation mapping. The Behavioral and Brain Sciences, 2, 189–230.Google Scholar
Schlaggar, B.L., Brown, T.T., Lugar, H.M., Visscher, K.M., Miezin, F.M., & Petersen, S.E. (2002). Functional neuroanatomical differences between adults and school-age children in the processing of single words. Science, 296, 1476–1479.Google Scholar
Szaflarski, J.P., Schmithorst, V.J., Altaye, M., Byars, A.W., Ret, J., Plante, E., & Holland, S.K. (2006). A longitudinal functional magnetic resonance imaging study of language development in children 5 to 11 years old. Annals of Neurology, 59, 796–807.Google Scholar
Thiebaut de Schotten, M., Urbanski, M., Duffau, H., Volle, E., Levy, R., Dubois, B., & Bartolomeo, P. (2005). Direct evidence for a parietal-frontal pathway subserving spatial awareness in humans. Science, 309, 2226–2228.Google Scholar
Wood, A.G., Harvey, A.S., Wellard, R.M., Abbott, D.F., Anderson, V., Kean, M., Saling, M.M., & Jackson, G.D. (2004). Language cortex activation in normal children. Neurology, 63, 1035–1044.Google Scholar
Yuan, W., Szaflarski, J.P., Schmithorst, V.J., Schapiro, M., Byars, A.W., Strawsburg, R.H., & Holland, S.K. (2006). fMRI shows atypical language lateralization in pediatric epilepsy patients. Epilepsia, 47, 593–600.Google Scholar