Our national scientific enterprise has a crisis of reproducibility. While this phenomenon has many contributors, one is the proliferation of data manipulation. Data manipulation may range from seemingly innocuous to brazen to the point of verging on criminal. This latter category has recently received more attention, stimulating a debate about the handling of such unpleasant matters. We co-authors have instigated and interacted with numerous research integrity investigations and believe the current model of handling potential violations of research integrity standards is deeply flawed. Institution-led investigations are fundamentally conflicted because of the potential for institutional reputational damage and financial harm from a finding of research misconduct. Concerns are often handled with secrecy, lethargy, and limited technical analysis. Integrity lapses are frequently handled with a lack of openness, accountability and proportional consequences, which have weakened public trust in the scientific enterprise.

We propose that research integrity violations of substantial scale should be independently investigated by appropriately resourced specialists. Such investigations should be completed within a time frame that facilitates meaningful corrective action when required or exoneration of the accused party when appropriate; completion of an investigation should rarely extend beyond one year and the results of the investigation should be made public.