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Laryngeal paraganglioma. A review and report of a single case

Published online by Cambridge University Press:  29 June 2007

Adnan Özünlü ,
Ahmet Dündar ,
Bülent Satar  and
Ömer Günhan
Adnan Özünlü*
Affiliation:
Department of Otorhinolaryngology – Head and Neck SurgeryGülhane Military Medical Academy, Etlik-Ankara, Turkey.
Ahmet Dündar
Affiliation:
Department of Otorhinolaryngology – Head and Neck SurgeryGülhane Military Medical Academy, Etlik-Ankara, Turkey.
Bülent Satar
Affiliation:
Department of Otorhinolaryngology – Head and Neck SurgeryGülhane Military Medical Academy, Etlik-Ankara, Turkey.
Ömer Günhan
Affiliation:
Department of Pathology, Gülhane Military Medical Academy, Etlik-Ankara, Turkey.
*
Address for correspondence: Address for correspondence: Adnan Özünlü, M.D., Asst. Prof., Gülhane Military Medical Academy, Otolaryngology – Head and Neck Surgery Department, Etlik-Ankara, 06018 – Turkey. Fax: 90 312 3127778
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Abstract

Laryngeal paraganglioma originates in the neural crest cells in the laryngeal paraganglia. Two distinct types may be cited on the basis of clinical features, but biopsy is essential for diagnosis. By light microscopy, the Zellballen pattern appears pathognomonic. The treatment consists of surgical excision.

In this article, due to the rareness of the tumour, one case of laryngeal paraganglioma is presented. The general knowledge and the available literature are reviewed. The difficulties in the differential diagnosis are stressed and treatment principles are discussed.

Keywords

LarynxParaganglioma

Information

Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 6 , June 1996 , pp. 519 - 526
Copyright
Copyright © JLO (1984) Limited 1996

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References

Ali, S., Aird, D. W., Bihari, J. (1983) Pain-induced laryngeal paragangliomas (non-chromaffin). Journal of Laryngology and Otology 97: 181–188.CrossRefGoogle Scholar
Andrews, A. H. (1955) Glomus tumour (non-chromaffin paraganglioma) of the larynx: Case report. Annals of Otology, Rhinology and Laryngology 64: 1034–1036.CrossRefGoogle ScholarPubMed
Banner, B., Morecki, R., Eviator, A. (1979) Chemodectoma in the mid-thyroid region. Journal of Otolaryngology 8: 271–273.Google ScholarPubMed
Barak, A. (1982) Paragangliomas of the head and neck: a review of the literature and report of a case. Journal of American Osteopathic Association 81: 783–789.Google ScholarPubMed
Barnes, L. (1991) Paragangliomas of the larynx. A critical review of literature. ORL 53: 220–234.CrossRefGoogle Scholar
Batsakis, J. G. (1979) Paragangliomas of the head and neck. In Tumours of the Head and Neck, Clinical and Pathological Considerations. 2nd Edition, Williams and Wilkins, Baltimore, pp 369–380.Google Scholar
Baugh, R., McClatchey, K., Sprile, S., Jones, H. (1987) Laryngeal paraganglioma. Journal of Otolaryngology 16: 167–168.Google ScholarPubMed
Blanchard, C. L., Saunders, W. H. (1955) Chemodectoma of the larynx: Case report. Archives of Otolaryngology 61: 472–474.CrossRefGoogle ScholarPubMed
Brownlee, R. E., Shockley, W. W. (1992) Thyroid paraganglioma. Annals of Otology, Rhinology and Laryngology 101: 293–299.CrossRefGoogle ScholarPubMed
Buss, D., Marshall, R., Baird, F., Meyers, R. (1980) Paraganglioma of the thyroid gland. American Journal of Surgical Pathology 4: 589–593.CrossRefGoogle ScholarPubMed
Choi, H. H., Anderson, P. J. (1985) Immunohistochemical diagnosis of olfactory neuroblastoma. Journal of Neuropathology and Experimental Neurology 44: 18–31.CrossRefGoogle ScholarPubMed
Cohn, D. V., Elting, J. J., Frick, M., Elde, R. (1984) Selective localization of the parathyroid secretory protein-I/adrenal medulla chromagranin-a protein family in a wide variety of endocrine cells of the val. Endocrinology 114: 1963–1974.CrossRefGoogle Scholar
Crowther, J. A., Colman, B. H. (1987) Chemodectoma of the larynx. Journal of Laryngology and Otology 101: 1095–1098.CrossRefGoogle ScholarPubMed
Deleu, D., De Geeter, F. (1991) Neurological manifestations of neuroendocrine neoplasms of the larynx. ORL 53: 250–258.CrossRefGoogle ScholarPubMed
De Vries, E., Watson, C. (1989) Paraganglioma of the thyroid. Head and Neck Surgery 11: 462–465.Google ScholarPubMed
El-Silimy, O., Harvy, L. (1992) A clinico-pathological classification of laryngeal paraganglioma. Journal of Laryngology and Otology 106: 635–639.CrossRefGoogle ScholarPubMed
Enzinger, F. M., Weiss, S. W. (1995) Soft tissue tumors. 3rd Edition. Mosby, St Louis p 975.Google Scholar
Ferlito, A., Friedmann, I. (1991) Contribution of immunohistochemistry in the diagnosis of neuroendocrine neoplasms of the larynx. ORL 53: 235–244.CrossRefGoogle ScholarPubMed
Ferlito, A., Barnes, L., Wenig, B. M. (1994) Identification, classification, treatment and prognosis of laryngeal paraganglioma. Review of the literature and eight new cases. Annals of Otology, Rhinology and Laryngology 103: 525–536.CrossRefGoogle ScholarPubMed
Glenner, G. G., Grimley, P. M. (1974) Tumours of the extra adrenal paraganglion system (including chemoreceptors). In Atlas of Tumor Pathology. Second Series Fascicle 9, Washington D.C., Armed Forces Institute of Pathology, p 67.Google Scholar
Handel, S. F., Miller, M. H., Wallace, S. (1977) Angiographic observation on chemodectomas of the head and neck. American Journal of Roentgenology 129: 477–480.CrossRefGoogle ScholarPubMed
Hooper, R. (1972) Chemodectoma of the glomus laryngicum superior. Laryngoscope 82: 686–692.CrossRefGoogle ScholarPubMed
Johnson, T. L., Zarbo, R. J., Lloyd, R. V., Crissman, J. D. (1988) Paragangliomas of the head and neck: immunohistochemical neuroendocrine and intermediate filament typing. Modern Pathology 1: 216–223.Google ScholarPubMed
Justrabo, E., Michiels, R., Calmettes, C., Cabanne, F., Bastein, H., Horiot, J. C., Guerrin, J. (1980) An uncommon apudoma. A functional chemodectoma of the larynx. Ada Otolaryngologica 89: 135–143.CrossRefGoogle ScholarPubMed
Kay, S., Montague, J., Dodd, R. (1975) Nonchromaffin paraganglioma (chemodectoma) of thyroid region. Cancer 36: 582–585.3.0.CO;2-O>CrossRefGoogle ScholarPubMed
Kleinsasser, O. (1988) Neuroendocrine tumours. In Tumours of the Larynx and Hypopharynx. Thieme Medical Publishers Inc., New York, pp 282–286.Google Scholar
Kliewer, K. E., Wen, D. R., Cancilla, P. A., Cochran, A. J. (1989) Paragangliomas: assessment of prognosis by histologic, immunohistochemical and ultrastructural techniques. Human Pathology 20: 29–39.CrossRefGoogle ScholarPubMed
Konowitz, P. M., Lawson, W., Som, P. M., Urken, M. L., Breakstone, B. A., Biller, H. F. (1988) Laryngeal paraganglioma: Update on diagnosis and treatment. Laryngoscope 98: 40–49.CrossRefGoogle ScholarPubMed
Korat, O., Trojanovski, J. Q., Livolis, V. A., Merino, M. J. (1988) Antigen expression in normal paraganglia and paragangliomas. Surgical Pathology 1: 33–39.Google Scholar
Lack, E. E., Cubilla, A. L., Woodruff, J. M., Farr, H. W. (1977) Paraganglioma of the head and neck region. Cancer 39, 397–09.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Lack, E., E., Cubilla, A. L., Woodruff, J. M. (1979) Paraganglioma of the head and neck region. Human Pathology 10: 191–218.CrossRefGoogle ScholarPubMed
Laudadio, P. (1971) Chemodectoma (paraganglioma nonchromaffine) del glomo laringeo superiore. Otorinolaringologica Italia 39: 19–31.Google Scholar
Lawson, W., Zak, F. G. (1974) The glomus bodies (‘Paraganglia’) of the human larynx. Laryngoscope 83: 98–111.CrossRefGoogle Scholar
Levene, A. (1981) Review: Pathological factors influencing excision of tumours in the head and neck. Part II. Clinical Otolaryngology 6: 209–215.CrossRefGoogle Scholar
Lloyd, R. V., Blaivas, M., Wilson, B. S. (1983) Specific endocrine marker defined by a monoclonal antibody. Science 222: 628–630.CrossRefGoogle ScholarPubMed
Lloyd, R. V. (1988) Immunohistochemical localization of cathecholamines, cathecolamine synthesizing enzymes and chromogranines in neuroendocrine cells tumors. In Advances in Immunohistochemistry, (De Lellis, R. A., Ed.). Raven Press, New York, pp 317–339.Google Scholar
Marks, P. V., Brookes, G. B. (1983) Malignant paraganglioma of the larynx. Journal of Laryngology and Otology 97: 1183–1188.CrossRefGoogle ScholarPubMed
Martinez-Madrigal, F., Bosq, M. J., Micheau, C. H., Nivet, P., Luboinski, B. (1991) Paragangliomas of the head and neck. Immunohistochemical analysis of 16 cases in comparison with neuro-endocrine carcinomas. Pathology, Research and Practice 187: 814–823.CrossRefGoogle ScholarPubMed
Massaioli, N., Balbo, G., Fausone, G., Negro, D. (1979) Paraganglioma branchiomerico endotiroideo (non-chromaffine). Minerva Chirurgica 34: 867–874.Google Scholar
Milroy, C. M., Williams, R. A., Charlton, I. G., Moss, E., Rode, J. (1991) Nuclear ploidy in neuroendocrine neoplasms of the larynx. ORL 53: 245–249.CrossRefGoogle ScholarPubMed
Mitsuda, S., Grajower, M., Balbi, H., Silver, C. (1987) Malignant paraganglioma of the thyroid gland. Archives of Pathology and Laboratory Medicine 111: 378–380.Google Scholar
Mittal, K. R., Hartman, G., True, L. V. (1986) Immunohistochemical profile of retroperitoneal carcinomas. Laboratory Investigation 54: 52A.Google Scholar
Moisa, I. I., Silver, C. E. (1991) Treatment of neuroendocrine neoplasms of the larynx. ORL 53: 259–264.CrossRefGoogle ScholarPubMed
Moisa, I. I. (1991) Neuroendocrine tumours of the larynx. Head and Neck 13 (6): 498–508.CrossRefGoogle Scholar
Olofsson, J., Grontoft, O., Sokjer, H., Kisberg, B. (1984) Paraganglioma involving the larynx. ORL 46: 57–65.CrossRefGoogle ScholarPubMed
Rufenacht, H., Mihatsch, M. I., Jundt, K., Gachter, A., Tanner, K., Heitz, P. U. (1985) Gastric epitheloid leiomyomas, pulmonary chondroma, non-functioning metastasizing extra-adrenal paraganglioma and myxoma. A variant of Carney's triad. Report of a patient. Klinische Wochenschrift 63: 282–284.CrossRefGoogle ScholarPubMed
Salim, S. A., Milroy, C., Rode, J., Corrins, B., Hamid, Q. (1993) Immunocytochemical characterization of neuroendocrine tumours of the larynx. Histopathology 23: 69–73.CrossRefGoogle ScholarPubMed
Schaefer, S. D., Blend, B. L., Denton, J. G. (1980) Laryngeal paragangliomas: evaluation and treatment. American Journal of Otolaryngology 1: 451–455.CrossRefGoogle ScholarPubMed
Smith, O., Youngs, R., Snell, D., Van Nostrand, P. (1988) Paraganglioma of the larynx. Journal of Otolaryngology 17: 293–301.Google ScholarPubMed
Sneige, N., Mackay, B., Ordonez, N. G., Batsakis, J. G. (1983) Laryngeal paraganglioma. Report of two tumours with immunohistochemical and ultrastructural analysis. Archives of Otolaryngology 109: 113–117.CrossRefGoogle ScholarPubMed
Stanley, R. J., Weiland, L. H., Neel, H. B. (1986) Paininducing laryngeal paraganglioma: Report of the ninth case and review of the literature. Otolaryngology – Head and Neck Surgery 95: 107–112.CrossRefGoogle ScholarPubMed
Sykes, J. M., Ossoff, R. H. (1986) Paragangliomas of the head and neck. Otolaryngologic Clinics of North America 19: 755–767.CrossRefGoogle ScholarPubMed
Tezel, I., Onart, S., Erisen, L., Tolunay, S. (1989) Laryngeal paraganglioma. Proceedings of 20th Turkish National Otorhinolaryngology Congress, Girne/Cyprus, pp 133–134.Google Scholar
Vetters, J. M., Toner, P. G. (1970) Chemodectoma of larynx. Journal of Pathology 101: 259–265.CrossRefGoogle ScholarPubMed
Wenig, B. M., Gnepp, D. R. (1989) The spectrum of neuroendocrine carcinomas of the larynx. Seminars in Diagnostic Pathlogy 6: 329–350.Google ScholarPubMed
Wenig, B. M. (1992) Neuroendocrine of the larynx. Letter to the Editor. Head and Neck 14: 332–334.CrossRefGoogle ScholarPubMed
Werner, J. A., Hansmann, M. L., Lippert, B. M., Rudert, U. (1992) Laryngeal paraganglioma and pregnancy. ORL 54: 163–167.CrossRefGoogle ScholarPubMed
Wetmore, R. F., Tronso, R. D., Lane, R. J., Lowry, L. D. (1981) Nonfunctional paraganglioma of the larynx. Cancer 48: 2717–2723.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
Wilson, B. S., Lloyd, R. V. (1984) Detection of chromografin in neuroendocrine cells with a monoclonal antibody. American Journal of Pathology 115: 458–468.Google ScholarPubMed
Zak, F. G., Lawson, W. (1972) Glomic (paraganglionic) tissue in the larynx and the capsule of the thyroid gland. Mount Sinai Journal of Medicine 39: 82–90.Google ScholarPubMed