Hostname: page-component-54dcc4c588-mz6gc Total loading time: 0 Render date: 2025-10-03T06:41:27.137Z Has data issue: false hasContentIssue false

Delayed facial nerve palsy following otological surgery: systematic review and narrative synthesis

Published online by Cambridge University Press:  29 August 2025

Ben Walters
Affiliation:
Department of Paediatric Surgery, Sheffield Children’s Hospital, Sheffield, UK
Sanjay Patel*
Affiliation:
Department of ENT, Birmingham Women’s and Children’s Hospital, Birmingham, UK
Valerie Kim
Affiliation:
Department of ENT, NHS Fife, Kirkcaldy, Fife, Scotland, UK
Hussein Walijee
Affiliation:
Department of ENT, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK
*
Corresponding author: Sanjay Patel; Email: s.patel9@doctors.org.uk

Abstract

Objectives

This study aimed to review the incidence, outcomes and treatment of delayed facial nerve palsy (DFP) following otological surgery.

Methods

MEDLINE, Pubmed, Embase and The Cochrane Central Register of Controlled Trials were searched up to 10 May 2024. A systematic review was conducted per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines of studies reporting on DFP following otological surgery. The risk of bias was assessed using the JBI critical appraisal tools.

Results

Forty-nine articles were included with 201 instances of DFP following 24,917 operations from 1967 to 2021. The mean day of onset post-operatively was 8.4. 93 per cent of episodes fully recovered, with most cases taking between eight days and one month to recover.

Conclusion

Many theories of the pathogenesis of DFP exist. It is rare and has an excellent prognosis following treatment with corticosteroids with or without anti-viral therapy.

Information

Type
Review Article
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

*Contributed equally

Sanjay Patel takes responsibility for the integrity of the content of the paper

References

Bae, SH, Kwak, SH, Nam, G-S, Jung, J. Meta-analysis of delayed facial palsy following middle ear surgery. Otol Neurotol 2019;40:1109–15Google Scholar
Hotton, M, Huggons, E, Hamlet, C, Shore, D, Johnson, D, Norris, JH, et al. The psychosocial impact of facial palsy: a systematic review. Br J Health Psychol 2020;25:695727Google Scholar
Patel, S, Walters, B, Kim, V, Walijee, H. Immediate facial nerve palsy secondary to otological surgery: a systematic review and narrative synthesis. Otol Neurotol 2024;45:619–26Google Scholar
Mat Lazim, N, Ismail, H, Abdul Halim, S, Nik Othman, NA, Haron, A. Comparison of 3 grading systems (House-Brackmann, Sunnybrook, Sydney) for the assessment of facial nerve paralysis and prediction of neural recovery. Medeni Med J 2023;38:111–19Google Scholar
Eckermann, J, Meyer, JE, Guenzel, T. Etiology and therapy of delayed facial paralysis after middle ear surgery. Eur Arch Otorhinolaryngol 2020;277:965–74Google Scholar
Lovin, BD, Sweeney, AD, Chapel, AC, Alfonso, K, Govil, N, Liu, Y-CC. Effects of age on delayed facial palsy after otologic surgery: a systematic review and meta-analysis. Ann Otol Rhinol Laryngol 2022;131:1092–101Google Scholar
Bonkowsky, V, Kochanowski, B, Strutz, J, Pere, P, Hosemann, W, Arnold, W. Delayed facial palsy following uneventful middle ear surgery: a herpes simplex virus type 1 reactivation? Ann Otol Rhinol Laryngol 1998;107:901–5Google Scholar
Page, MJ, McKenzie, JE, Bossuyt, PM, Boutron, I, Hoffmann, TC, Mulrow, CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71Google Scholar
Aromataris, E, Lockwood, C, Porritt, K, Pilla, B, Jordan, Z, eds. JBI Manual for Evidence Synthesis JBI; 2024. In: https://synthesismanualjbiglobal https://doi.org/1046658/JBIMES-24-01 [8 September 2025].Google Scholar
OCEBM Levels of Evidence Working Group “The Oxford Levels of Evidence 2” Oxford Centre for Evidence-Based Medicine. In: https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence [8 September 2025]Google Scholar
Ahn, JH, Chung, JW, Lee, K-S. Complications following cochlear implantation in patients with anomalous inner ears: experiences in Asan Medical Center. Acta Otolaryngol 2008;128:3842Google Scholar
Aldhafeeri, AM, Alsanosi, AA. Management of surgical difficulties during cochlear implant with inner ear anomalies. Int J Pediatr Otorhinolaryngol 2017;92:45–9Google Scholar
Althaus, SR, House, HP. Delayed post-stapedectomy facial paralysis: a report of five cases. Laryngoscope 1973;83:1234–40Google Scholar
Alzhrani, F, Lenarz, T, Teschner, M. Facial palsy following cochlear implantation. Eur Arch Otorhinolaryngol 2016;273:4199–207Google Scholar
Basavaraj, S, Prakash, BG, Shetty, TS, Sandhya, D, Kallada, S. Delayed facial nerve weakness after intact canal wall tympanomastoidectomy. Otol Neurotol 2014;35:1003–6Google Scholar
Bhatia, K, Gibbin, KP, Nikolopoulos, TP, O’Donoghue, GM. Surgical complications and their management in a series of 300 consecutive pediatric cochlear implantations. Otol Neurotol 2004;25:730–9Google Scholar
Black, IM, Bailey, CM, Albert, DM, Leighton, SE, Hartley, BEJ, Chatrath, P, et al. The Great Ormond Street Hospital paediatric cochlear implant programme 1992-2004. A review of surgical complications. Cochlear Implants Int 2007;8:5367Google Scholar
Çelenk, F, Cevizci, R, Altınyay, Ş, Bayazıt, YA. Cochlear implantation in extraordinary cases. Balkan Med J 2015;32:208–13Google Scholar
Cohen, M, Balaker, A, Kirsch, C, Mendelsohn, A, Ishiyama, A. Magnetic resonance imaging findings in delayed facial palsy after stapes surgery. Otol Neurotol 2010;31:1153–6Google Scholar
Di Berardino, F, Zanetti, D. Typical or atypical Ramsay-Hunt Syndrome in delayed facial palsy after stapedectomy? J Int Adv Otol 2018;14:233–8Google Scholar
Durcan, DJ, Shea, JJ, Sleeckx, JP. Bifurcation of the facial nerve. Arch Otolaryngol 1967;86:619–31Google Scholar
Eskander, A, Holler, T, Papsin, BC. Delayed facial nerve paresis after using the KTP laser in the treatment of cholesteatoma despite inter-operative facial nerve monitoring. Int J Pediatr Otorhinolaryngol 2010;74:823–4Google Scholar
Farinetti, A, Ben Gharbia, D, Mancini, J, Roman, S, Nicollas, R, Triglia, J-M. Cochlear implant complications in 403 patients: comparative study of adults and children and review of the literature. Eur Ann Otorhinolaryngol Head Neck Dis 2014;131:177–82Google Scholar
Fayad, JN, Wanna, GB, Micheletto, JN, Parisier, SC. Facial nerve paralysis following cochlear implant surgery. Laryngoscope 2003;113:1344–6Google Scholar
Gyo, K, Honda, N. Delayed facial palsy after middle-ear surgery due to reactivation of varicella-zoster virus. J Laryngol Otol 1999;113:914–15Google Scholar
Hansen, S, Anthonsen, K, Stangerup, S-E, Jensen, JH, Thomsen, J, Cayé-Thomasen, P. Unexpected findings and surgical complications in 505 consecutive cochlear implantations: a proposal for reporting consensus. Acta Otolaryngologica 2010;130:540–9Google Scholar
Hsieh, H-S, Wu, C-M, Zhuo, M-Y, Yang, C-H, Hwang, C-F. Intraoperative facial nerve monitoring during cochlear implant surgery: an observational study. Medicine (Baltimore) 2015;94:e456Google Scholar
Ishikawa, Y, Hosoya, M, Kanzaki, S, Ogawa, K. Delayed facial palsy after cochlear implantation caused by reactivation of Herpesvirus: a case report and review of the literature. Auris Nasus Larynx 2022;49:880–4Google Scholar
Jeppesen, J, Faber, CE. Surgical complications following cochlear implantation in adults based on a proposed reporting consensus. Acta Otolaryngol 2013;133:1012–21Google Scholar
Joseph, ST, Vishwakarma, R, Ramani, MK, Aurora, R. Cochlear implant and delayed facial palsy. Cochlear Implants Int 2009;10:229–36Google Scholar
Kamalden, TMIT, Yusof, ANM, Misron, K. A review of delayed facial nerve paresis as complication following total endoscopic ear surgery. J Int Adv Otol 2021;17:570–3Google Scholar
Lalwani, AK, Larky, JB, Wareing, MJ, Kwast, K, Schindler, RA. The Clarion Multi-Strategy Cochlear Implant–surgical technique, complications, and results: a single institutional experience. Am J Otol 1998;19:6670Google Scholar
Li, K-H, Chan, L-P, Chen, C-K, Kuo, S-H, Wang, L-F, Chang, N-C, et al. Comparative study of endoscopic and microscopic type i tympanoplasty in terms of delayed facial palsy. Otolaryngol Head Neck Surg 2021;164:645–51Google Scholar
Marioni, G, de Filippis, C, Gaio, E, Staffieri, A. Delayed facial nerve palsy following uneventful stapedectomy. ORL J Otorhinolaryngol Relat Spec 2002;64:45–8Google Scholar
Migirov, L, Muchnik, C, Kaplan-Neeman, R, Kronenberg, J. Surgical and medical complications in paediatric cochlear implantation: a review of 300 cases. Cochlear Implants Int 2006;7:194201Google Scholar
Migirov, L, Taitelbaum-Swead, R, Drendel, M, Hildesheimer, M, Kronenberg, J. Cochlear implantation in elderly patients: surgical and audiological outcome. Gerontology 2010;56:123–8Google Scholar
Migirov, L, Yakirevitch, A, Kronenberg, J. Surgical and medical complications following cochlear implantation: comparison of two surgical approaches. ORL J Otorhinolaryngol Relat Spec 2006;68:213–9Google Scholar
Mills, R, Szymanski, M, Abel, E. Delayed facial palsy following laser stapedectomy: in vitro study of facial nerve temperature. Clin Otolaryngol Allied Sci 2003;28:211–14Google Scholar
Miyamoto, RT, Young, M, Myres, WA, Kessler, K, Wolfert, K, Kirk, KI. Complications of pediatric cochlear implantation. Eur Arch Otorhinolaryngol 1996;253:14Google Scholar
Ng, M, Maceri, DR. Delayed facial paralysis after stapedotomy using KTP laser. Am J Otol 1999;20:421–4Google Scholar
Qiu, J, Chen, Y, Tan, P, Chen, J, Han, Y, Gao, L, et al. Complications and clinical analysis of 416 consecutive cochlear implantations. Int J Pediatr Otorhinolaryngol 2011;75:1143–6Google Scholar
Révész, P, Piski, Z, Burián, A, Harmat, K, Gerlinger, I. Delayed facial paralysis following uneventful KTP laser stapedotomy: two case reports and a review of the literature. Case Rep Med 2014;2014:971362Google Scholar
Safdar, A, Gendy, S, Hilal, A, Walshe, P, Burns, H. Delayed facial nerve palsy following tympano-mastoid surgery: incidence, aetiology and prognosis. J Laryngol Otol 2006;120:745–8Google Scholar
Salvinelli, F, Casale, M, Vitaliana, L, Greco, F, Dianzani, C, D’Ascanio, L. Delayed peripheral facial palsy in the stapes surgery: can it be prevented? Am J Otolaryngol 2004;25:105–8Google Scholar
Shea, JJ. Thirty years of stapes surgery. J Laryngol Otol 1988;102:1419Google Scholar
Shea, JJ Jr, Ge, X. Delayed facial palsy after stapedectomy. Otol Neurotol 2001;22:465–70Google Scholar
Sheahan, P, Viani, L. Delayed facial palsy in a patient with a bifid facial nerve lending support for viral theory of facial palsy. Otol Neurotol 2007;28:414–16Google Scholar
Smith, MC, Simon, P, Ramalingam, KK. Delayed facial palsy following uncomplicated stapedectomy. J Laryngol Otol 1990;104:611–12Google Scholar
Stratigouleas, ED, Perry, BP, King, SM, Syms, CA. 3rd. Complication rate of minimally invasive cochlear implantation. Otolaryngol Head Neck Surg 2006;135:383–6Google Scholar
Tarkan, Ö, Tuncer, Ü, Özdemir, S, Sürmelioğlu, Ö, Çetik, F, Kıroğlu, M, et al. Surgical and medical management for complications in 475 consecutive pediatric cochlear implantations. Int J Pediatr Otorhinolaryngol 2013;77:473–9Google Scholar
Thom, JJ, Carlson, ML, Olson, MD, Neff, BA, Beatty, CW, Facer, GW, et al. The prevalence and clinical course of facial nerve paresis following cochlear implant surgery. Laryngoscope 2013;123:1000–4Google Scholar
Thorne, MC, Dunham, BP, Tom, LWC. Delayed facial paresis following tympanomastoid surgery in a pediatric patient. Ear Nose Throat J 2010;89:357–61Google Scholar
Vrabec, JT. Delayed facial palsy after tympanomastoid surgery. Am J Otol 1999;20:2630Google Scholar
Xu, HX, Deroee, AF, Joglekar, S, Pollak, N, Hobson, F, Santori, T, et al. Delayed facial nerve palsy after endolymphatic sac surgery. Ear Nose Throat J 2011;90:E2831Google Scholar
Xu, P, Liu, W, Zuo, W, Wang, D, Wang, H. Delayed facial palsy after tympanomastoid surgery: a report of 15 cases. Am J Otolaryngol 2015;36:805–7Google Scholar
Zhou, Y, Song, R, Li, Y. Clinical characteristics and outcomes of delayed facial palsy after tympanoplasty. Acta Otolaryngol 2015;135:201–4Google Scholar
Zohar, Y, Laurian, N. Facial palsy following stapedectomy: (a case report). J Laryngol Otol 1985;99:387–8Google Scholar
Guthikonda, B, Pensak, ML, Theodosopoulos, PV. Delayed facial palsy after the anterior petrosal approach: case report and review of the literature. Neurosurgery 2010;66:E8456Google Scholar
Price, RW. Herpes simplex virus latency: adaptation to the peripheral nervous system. II. Cancer Invest 1985;3:389403Google Scholar
Xu, D, Pollock, M. Experimental nerve thermal injury. Brain 1994;117:375–84Google Scholar
Moreano, EH, Paparella, MM, Zelterman, D, Goycoolea, MV. Prevalence of facial canal dehiscence and of persistent stapedial artery in the human middle ear: a report of 1000 temporal bones. Laryngoscope 1994;104:309–20Google Scholar
Baxter, A. Dehiscence of the Fallopian canal. An anatomical study. J Laryngol Otol 1971;85:587–94Google Scholar
Couch, B, Hayward, D, Baum, G, Sakthiyendran, NA, Harder, J, Hernandez, EJ, et al. A systematic review of steroid use in peripheral nerve pathologies and treatment. Front Neurol 2024;15:1434429Google Scholar
Gagyor, I, Madhok, VB, Daly, F, Sullivan, F. Antiviral treatment for Bell’s palsy (idiopathic facial paralysis). Cochrane Database Syst Rev 2019;9:CD001869Google Scholar
Supplementary material: File

Walters et al. supplementary material

Walters et al. supplementary material
Download Walters et al. supplementary material(File)
File 135.2 KB