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Filaricidal properties of a wild herb, Andrographis paniculata

Published online by Cambridge University Press:  18 November 2009

Anita Dutta  and
Nirmal C. Sukul
Anita Dutta
Affiliation:
Department of Zoology, Visva-Bharati University, Santiniketan 731235, West Bengal, India
Nirmal C. Sukul
Affiliation:
Department of Zoology, Visva-Bharati University, Santiniketan 731235, West Bengal, India
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Abstract

Water decoction of the leaves of Andrographis paniculata killed in vitro the microfilaria of Dipetalonema reconditum in 40 min. Three subcutaneous injections of the extract into infected dogs at 0·06 ml per kg bodyweight reduced the number of microfilariae in blood by more than 85%. The larvae were not totally eliminated with more infections but the reduced microfilarial level persisted. No toxiceffect of the extract was observed in rabbits. The treated dogs became lethargic initially for a week, probably due to the mass killing of microfilariae.

Information

Type
Research Papers
Information
Journal of Helminthology , Volume 56 , Issue 2 , June 1982 , pp. 81 - 84
Copyright
Copyright © Cambridge University Press 1982

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References

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