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The use of gamma-radiation-attenuated larvae of Gaigeria pachyscelis Railliet and Henry, 1910, for vaccination in lambs*

Published online by Cambridge University Press:  05 June 2009

Md. Zafrullah Ansari  and
Kunwar Suresh Singh
Md. Zafrullah Ansari
Affiliation:
Division of Parasitology, Indian Veterinary Research Institute, Izatnagar, (U.P.), India
Kunwar Suresh Singh
Affiliation:
Division of Parasitology, Indian Veterinary Research Institute, Izatnagar, (U.P.), India
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Abstract

The results of a vaccination trial in lambs with gamma-irradiated infective larvae of Gaigeria pachyscelis are described. A single percutaneous (P/C) vaccination of lambs with 2000 infective larvae irradiated at 40 Kr induced the development of resistance. The vaccinated lambs successfully resisted a lethal challenge infection of 5000 non-irradiated larvae 3 months later. In the vaccinated lambs, the manifestations of resistance were shown by marked reduction in the worm establishment, development of retarded and functionally sterile worms and absence of clinical signs of hookworm disease after the challenge infection.

Information

Type
Research Papers
Information
Journal of Helminthology , Volume 52 , Issue 4 , December 1978 , pp. 287 - 290
Copyright
Copyright © Cambridge University Press 1978

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References

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