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Chemoprophylactic studies with ivermectin against subperiodic Brugia malayi infection in the leaf monkey, Presbytis cristata

Published online by Cambridge University Press:  05 June 2009

J. W. Mak ,
P. L. W. Lam ,
A. Noor Rain  and
K. Suresh
J. W. Mak
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
P. L. W. Lam
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
A. Noor Rain
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
K. Suresh
Affiliation:
Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
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Abstract

Four Presbytis cristata were treated with oral ivermectin at the same time as the subcutaneous inoculation of 100 infective larvae monthly for three months. Two animals given 0·2 mg/kg monthly and two others given 0·3 mg/kg monthly as well as three control animals became patent for microfilaraemia. However, only 1% of the infective dose was recovered as adult worms from animals in the higher drug dosage group compared to 8·2% and 6·2% in the lower dosage and control groups respectively.

Keywords

Brugia malayiPresbytis cristataivermectin

Information

Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 4 , December 1987 , pp. 311 - 314
Copyright
Copyright © Cambridge University Press 1987

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References

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