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Placental expression of the obesity-associated gene FTO is reduced by fetal growth restriction but not by macrosomia in rats and humans

Published online by Cambridge University Press:  20 December 2012

S. Mayeur ,
O. Cisse ,
A. Gabory ,
S. Barbaux ,
D. Vaiman ,
A. Vambergue ,
I. Fajardy ,
S. Deloof ,
C. Junien  and
C. Laborie
...Show all authors
S. Mayeur
Affiliation:
Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France
O. Cisse
Affiliation:
Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France
A. Gabory
Affiliation:
Biologie du Développement et Reproduction, UMR INRA-ENVA-CNRS Jouy en Josas, France
S. Barbaux
Affiliation:
Institut Cochin, Univ Paris Descartes, CNRS, UMR 8104; INSERM U 1016, Paris, France
D. Vaiman
Affiliation:
Institut Cochin, Univ Paris Descartes, CNRS, UMR 8104; INSERM U 1016, Paris, France
A. Vambergue
Affiliation:
Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France
I. Fajardy
Affiliation:
Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France
S. Deloof
Affiliation:
Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France
C. Junien
Affiliation:
Biologie du Développement et Reproduction, UMR INRA-ENVA-CNRS Jouy en Josas, France
C. Laborie
Affiliation:
Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France
D. Vieau
Affiliation:
Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France
J. Lesage*
Affiliation:
Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Université de Lille 1, Villeneuve d'Ascq, France
*
*Address for correspondence: Professor J. Lesage, Univ Lille Nord de France, Unité Environnement Périnatal et Croissance (EA4489), Université de Lille 1, Equipe Dénutritions Maternelles Périnatales, Bâtiment SN4, F-59655 Villeneuve d'Ascq, France. (Email jean.lesage@univ-lille1.fr)
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Abstract

Genetic variants in the FTO (fat mass- and obesity-associated) gene have the highest association of all obesity-associated genes. Its placental expression was shown to relate to birth weight, suggesting that it may participate in the control of fetal weight gain. To gain more insight into the implication of FTO in fetal growth, we measured its placental expression in samples including extremes of abnormal fetal growth, such as after intrauterine growth restriction (IUGR) or macrosomia in both rats and humans. In rats, fetal growth was modulated by maternal nutritional modifications. In humans, placental villi were collected from pathological pregnancies (i.e. with IUGR or fetal macrosomia). Placental FTO mRNA expression was reduced by IUGR but was not significantly affected by macrosomia in either rats or humans. Our data suggest that placental FTO may participate in interactions between the in utero environment and the control of fetal growth under IUGR conditions by modulating epigenetic processes.

Keywords

fetal growthFTOhumanplacentarat

Information

Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 4 , Issue 2 , April 2013 , pp. 134 - 138
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2012 

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