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Implementation and outcomes of a clinician-directed intervention to improve antibiotic prescribing for acute respiratory tract infections within the Veterans’ Affairs Healthcare System

Published online by Cambridge University Press:  15 August 2022

Karl J. Madaras-Kelly Open the ORCID record for Karl J. Madaras-Kelly [Opens in a new window] ,
Suzette A. Rovelsky ,
Robert A. McKie Open the ORCID record for Robert A. McKie [Opens in a new window] ,
McKenna R. Nevers ,
Jian Ying ,
Benjamin A. Haaland ,
Chad L. Kay ,
Melissa L. Christopher Open the ORCID record for Melissa L. Christopher [Opens in a new window] ,
Lauri A. Hicks  and
Mathew H. Samore
Karl J. Madaras-Kelly*
Affiliation:
Boise Veterans’ Affairs (VA) Medical Center, Boise, Idaho College of Pharmacy, Idaho State University, Meridian, Idaho
Suzette A. Rovelsky
Affiliation:
Boise Veterans’ Affairs (VA) Medical Center, Boise, Idaho
Robert A. McKie
Affiliation:
Boise Veterans’ Affairs (VA) Medical Center, Boise, Idaho
McKenna R. Nevers
Affiliation:
Salt Lake City VA Health Care System, Salt Lake City, Utah University of Utah School of Medicine, Salt Lake City, Utah
Jian Ying
Affiliation:
Salt Lake City VA Health Care System, Salt Lake City, Utah University of Utah School of Medicine, Salt Lake City, Utah
Benjamin A. Haaland
Affiliation:
Salt Lake City VA Health Care System, Salt Lake City, Utah University of Utah School of Medicine, Salt Lake City, Utah
Chad L. Kay
Affiliation:
VA National Academic Detailing Service, St. Louis, Missouri
Melissa L. Christopher
Affiliation:
VA National Academic Detailing Service, San Diego, California
Lauri A. Hicks
Affiliation:
Centers for Disease Control and Prevention (CDC), Atlanta, Georgia
Mathew H. Samore
Affiliation:
Salt Lake City VA Health Care System, Salt Lake City, Utah University of Utah School of Medicine, Salt Lake City, Utah
*
Author for correspondence: Karl J. Madaras-Kelly, E-mail: Karl.Madaras-Kelly2@va.gov
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Abstract

Objective:

To determine whether a clinician-directed acute respiratory tract infection (ARI) intervention was associated with improved antibiotic prescribing and patient outcomes across a large US healthcare system.

Design:

Multicenter retrospective quasi-experimental analysis of outpatient visits with a diagnosis of uncomplicated ARI over a 7-year period.

Participants:

Outpatients with ARI diagnoses: sinusitis, pharyngitis, bronchitis, and unspecified upper respiratory tract infection (URI-NOS). Outpatients with concurrent infection or select comorbid conditions were excluded.

Intervention(s):

Audit and feedback with peer comparison of antibiotic prescribing rates and academic detailing of clinicians with frequent ARI visits. Antimicrobial stewards and academic detailing personnel delivered the intervention; facility and clinician participation were voluntary.

Measure(s):

We calculated the probability to receive antibiotics for an ARI before and after implementation. Secondary outcomes included probability for a return clinic visits or infection-related hospitalization, before and after implementation. Intervention effects were assessed with logistic generalized estimating equation models. Facility participation was tracked, and results were stratified by quartile of facility intervention intensity.

Results:

We reviewed 1,003,509 and 323,023 uncomplicated ARI visits before and after the implementation of the intervention, respectively. The probability to receive antibiotics for ARI decreased after implementation (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.78–0.86). Facilities with the highest quartile of intervention intensity demonstrated larger reductions in antibiotic prescribing (OR, 0.69; 95% CI, 0.59–0.80) compared to nonparticipating facilities (OR, 0.89; 95% CI, 0.73–1.09). Return visits (OR, 1.00; 95% CI, 0.94–1.07) and infection-related hospitalizations (OR, 1.21; 95% CI, 0.92–1.59) were not different before and after implementation within facilities that performed intensive implementation.

Conclusions:

Implementation of a nationwide ARI management intervention (ie, audit and feedback with academic detailing) was associated with improved ARI management in an intervention intensity–dependent manner. No impact on ARI-related clinical outcomes was observed.

Information

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 44 , Issue 5 , May 2023 , pp. 746 - 754
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Creative Commons
This is a work of the US Government and is not subject to copyright protection within the United States. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America.
Copyright
© Department of Veterans Affairs, 2022

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