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Feasibility of Azithromycin Prophylaxis During a Pertussis Outbreak Among Healthcare Workers in a University Hospital in Paris

Published online by Cambridge University Press:  21 June 2016

Camila Giugliani ,
Gwenaëlle Vidal-Trécan ,
Souleymane Traore ,
Hervé Blanchard ,
Gabriela Spiridon ,
Florence Rollot ,
Odile Launay ,
Myriam Gorodestski ,
Jean-Luc Marande  and
Christophe Vinsonneau
...Show all authors
Camila Giugliani
Affiliation:
Service de Santé Publique, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Gwenaëlle Vidal-Trécan
Affiliation:
Service de Santé Publique, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Souleymane Traore
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Hervé Blanchard
Affiliation:
Service d'Hygiène Hospitalière, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Gabriela Spiridon
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Florence Rollot
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Odile Launay
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Myriam Gorodestski
Affiliation:
Service de Médecine du Travail, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Jean-Luc Marande
Affiliation:
Service de Médecine du Travail, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Christophe Vinsonneau
Affiliation:
Service d'Hygiène Hospitalière, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Loïc Guillevin
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
Dominique Salmon-Céron*
Affiliation:
Service de Médecine Interne, Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France Groupe Hospitalier Cochin–St. Vincent de Paul, AP-HP, and the Département de Santé Publique, Faculté de Médecine, Université Paris Descartes, Paris, France
*
Service de Médecine Interne Unité de Maladies Infectieuses, Groupe Hospitalier Cochin–St. Vincent de Paul, 27, rue du Faubourg Saint Jacques 75014 Paris, France (dominique.salmon@cch.ap-hop-paris.fr)
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Abstract

The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%. Female sex was associated with reporting of adverse events. Nonstudents and healthcare workers who reported adverse events were less compliant with the prophylaxis regimen.

Information

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 6 , June 2006 , pp. 626 - 629
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

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