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Published online by Cambridge University Press: 14 April 2009
Gene frequency changes were followed in 17 experimental cage populations of Drosophila melanogaster polymorphic for the two loci G6PD and 6PGD. From these cages it was observed that selection was favouring the F alleles of both loci when the cages were started with low frequencies of these alleles (0·20F and 0·50F). A viability experiment and an extinction experiment also provided evidence that the F alleles of both loci were favoured. It is argued that the observed selection is not due to selective differences in genetic background of the different alleles, but is acting on the isozyme loci themselves.