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p38 activation and viral infection

Published online by Cambridge University Press:  21 January 2022

Luyao Wang ,
Zhiqiang Xia ,
Wei Tang ,
Yu Sun ,
Yingliang Wu ,
Hang Fai Kwok ,
Fang Sun  and
Zhijian Cao
Luyao Wang
Affiliation:
State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China
Zhiqiang Xia
Affiliation:
State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China
Wei Tang
Affiliation:
State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China
Yu Sun
Affiliation:
School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China
Yingliang Wu
Affiliation:
State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China
Hang Fai Kwok*
Affiliation:
Frontiers Science Center for Precision Oncology of MoE, University of Macau, Taipa, Macau, China Faculty of Health Sciences, Cancer Center, University of Macau, Avenida de Universidade, Taipa, Macau, China
Fang Sun*
Affiliation:
State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, Hubei, China
Zhijian Cao*
Affiliation:
State Key Laboratory of Virology and Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China
*
Author for correspondence: Hang Fai Kwok, E-mail: hfkwok@um.edu.mo; Fang Sun, E-mail: 2016202040055@whu.edu.cn; Zhijian Cao, E-mail: zjcao@whu.edu.cn
Author for correspondence: Hang Fai Kwok, E-mail: hfkwok@um.edu.mo; Fang Sun, E-mail: 2016202040055@whu.edu.cn; Zhijian Cao, E-mail: zjcao@whu.edu.cn
Author for correspondence: Hang Fai Kwok, E-mail: hfkwok@um.edu.mo; Fang Sun, E-mail: 2016202040055@whu.edu.cn; Zhijian Cao, E-mail: zjcao@whu.edu.cn
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Abstract

Viruses completely rely on the energy and metabolic systems of host cells for life activities. Viral infections usually lead to cytopathic effects and host diseases. To date, there are still no specific clinical vaccines or drugs against most viral infections. Therefore, understanding the molecular and cellular mechanisms of viral infections is of great significance to prevent and treat viral diseases. A variety of viral infections are related to the p38 MAPK signalling pathway, and p38 is an important host factor in virus-infected cells. Here, we introduce the different signalling pathways of p38 activation and then summarise how different viruses induce p38 phosphorylation. Finally, we provide a general summary of the effect of p38 activation on virus replication. Our review provides integrated data on p38 activation and viral infections and describes the potential application of targeting p38 as an antiviral strategy.

Keywords

Activationantiviral targetinfectionp38 MAPKvirus

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Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 24 , 2022 , e4
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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