The Innate Immune system, which includes the Complement System, is integral to health and disease. The innate immune system is the body's first line of defense against pathogens. The Complement System is a major humoral component of the innate immune system. 

We invite submissions to this Special Collection on Innate Immunity & the Complement System in Health and Disease via the Editorial Manager. You may want to discuss the suitability of your proposed reviews with one of our Special Collection Editors (see below).

Keywords include (but are not limited to):

Innate Immunity

Antimicrobial proteins and peptides in heath and disease

Pattern recognition receptors in immune activation, as adjuvants, and in diseases

The role of "innate memory" / "trained immunity" in health and disease

Innate immune responses to cancer

Innate immune regulation

The Complement System

Complement in Health and Disease

Intracellular complement

Complement in Cancer

Complement Biomarkers

Complement as a therapeutic target

Special collection editors

Meike Heurich-Sevcenco (heurichm@cardiff.ac.uk)

Christopher Schliehe (c.schliehe@erasmusmc.nl)

Submission Deadline

3rd November 2025