A whole-brain voxel-based analysis of structural abnormalities in PTSD: an ENIGMA-PGC study

Cheryl R Z See*: Affiliation:
Department of Psychosis, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom.
Shuqing Si: Affiliation:
Department of Psychosis, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom.
C. Lexi Baird: Affiliation:
Brain Imaging and Analysis Center, Duke University, Durham, NC, USA. Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.
Courtney C. Haswell: Affiliation:
Brain Imaging and Analysis Center, Duke University, Durham, NC, USA. Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.
Ahmed Hussain: Affiliation:
Brain Imaging and Analysis Center, Duke University, Durham, NC, USA. Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.
Miranda Olff: Affiliation:
Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands. ARQ National Psychotrauma Centre, Diemen, The Netherlands.
Dick J. Veltman: Affiliation:
Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Jessie Frijling: Affiliation:
De Viersprong Mental Health Specialist in Personality Disorders, Family and Behavior, Amsterdam, The Netherlands.
Mirjam van Zuiden: Affiliation:
Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands. Clinical Psychology, Utrecht University, Utrecht, The Netherlands.
Saskia B.J. Koch: Affiliation:
Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands. Donders Center for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands.
Laura Nawijn: Affiliation:
Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands. Institute of Psychology, Clinical Psychology, Leiden University, Leiden, The Netherlands.
Li Wang: Affiliation:
Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Ye Zhu: Affiliation:
Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Gen Li: Affiliation:
Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Center for Global Health Equity, New York University Shanghai, Shanghai, China.
Yuval Neria: Affiliation:
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA. New York State Psychiatric Institute, New York, NY, USA.
Xi Zhu: Affiliation:
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA. New York State Psychiatric Institute, New York, NY, USA.
Benjamin Suarez-Jimenez: Affiliation:
Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
Sigal Zilcha-Mano: Affiliation:
Department of Psychology, University of Haifa, Haifa, Israel.
Amit Lazarov: Affiliation:
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA. School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Jennifer Stevens: Affiliation:
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Kerry Ressler: Affiliation:
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA. Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Negar Fani: Affiliation:
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Tanja Jovanovic: Affiliation:
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA. Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI, USA.
Sanne van Rooij: Affiliation:
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Milissa Kaufman: Affiliation:
Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Division of Women’s Mental Health, McLean Hospital, Belmont, MA, USA.
Lauren Lebois: Affiliation:
Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA. Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Isabelle Rosso: Affiliation:
Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Center for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Elizabeth Olson: Affiliation:
Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Center for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Justin Baker: Affiliation:
Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA.
Scott Sponheim: Affiliation:
Minneapolis VA Health Care System, Minneapolis, MN, USA. Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Seth Disner: Affiliation:
Minneapolis VA Health Care System, Minneapolis, MN, USA. Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Nicholas Davenport: Affiliation:
Minneapolis VA Health Care System, Minneapolis, MN, USA. Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Amit Etkin: Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. VA Palo Alto Health Care System, Palo Alto, CA, USA.
Adi Maron-Katz: Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Murray Stein: Affiliation:
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Martha Shenton: Affiliation:
Department of Psychiatry, Neuroimaging Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. Department of Radiology, Brigham and Women’s Hospital, Boston, MA, USA. Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Dan Stein: Affiliation:
South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Jonathan Ipser: Affiliation:
South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Sheri-Michelle Koopowitz: Affiliation:
South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Soraya Seedat: Affiliation:
Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. South African Medical Research Council Unit on the Genomics of Brain Disorders (GBD), Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Stefan du Plessis: Affiliation:
Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. South African Medical Research Council Unit on the Genomics of Brain Disorders (GBD), Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Leigh van den Huevel: Affiliation:
Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. South African Medical Research Council Unit on the Genomics of Brain Disorders (GBD), Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Shmuel Lissek: Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Hannah Berg: Affiliation:
Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Thomas Straube: Affiliation:
Institute of Medical Psychology and Systems Neuroscience, University of Mu¨nster, Mu¨nster, Germany.
David Hoffman: Affiliation:
Institute of Medical Psychology and Systems Neuroscience, University of Mu¨nster, Mu¨nster, Germany.
Lee Baugh: Affiliation:
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA. Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA. Sioux Falls VA Health Care System, Sioux Falls, SD, USA.
Gina Forster: Affiliation:
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA. Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA. Brain Health Research Centre, Department of Anatomy, University of Otago, Dunedin, New Zealand.
Raluca Simons: Affiliation:
Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA. Department of Psychology, University of South Dakota, Vermillion, SD, USA. Disaster Mental Health Institute, Vermillion, SD, USA.
Jeffrey Simons: Affiliation:
Sioux Falls VA Health Care System, Sioux Falls, SD, USA. Department of Psychology, University of South Dakota, Vermillion, SD, USA.
Vincent Magnotta: Affiliation:
Departments of Radiology, Psychiatry, and Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
Kelene Fercho: Affiliation:
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA. Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA. Sioux Falls VA Health Care System, Sioux Falls, SD, USA. Civil Aerospace Medical Institute, US Federal Aviation Administration, Oklahoma City, OK, USA.
Xin Wang: Affiliation:
Department of Psychiatry, University of Toledo, Toledo, OH, USA.
Andrew Cotton: Affiliation:
Department of Psychiatry, University of Toledo, Toledo, OH, USA.
Erin O’Leary: Affiliation:
Department of Psychiatry, University of Toledo, Toledo, OH, USA.
Hong Xie: Affiliation:
Department of Neurosciences, University of Toledo, Toledo, OH, USA.
Daniel Grupe: Affiliation:
Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.
Jack Nitschke: Affiliation:
Department of Psychiatry, University of Wisconsin- Madison, Madison, WI, USA.
Richard Davidson: Affiliation:
Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA. Department of Psychiatry, University of Wisconsin- Madison, Madison, WI, USA. Department of Psychology, University of Wisconsin- Madison, Madison, WI, USA.
Christine Larson: Affiliation:
Department of Psychology, University of Wisconsin- Milwaukee, Milwaukee, WI, USA.
Terri deRoon-Cassini: Affiliation:
Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA. Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Carissa Tomas: Affiliation:
Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee, WI, USA. Division of Epidemiology and Social Sciences, Institute of Health and Equity, Medical College of Wisconsin Milwaukee, Milwaukee, WI, USA.
Jacklynn Fitzgerald: Affiliation:
Department of Psychology, Marquette University, Milwaukee, WI, USA.
Jennifer Urbano Blackford: Affiliation:
Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA. Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Bunmi Olatunji: Affiliation:
Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Evan Gordon: Affiliation:
Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Geoffrey May: Affiliation:
Veterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA. Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA. Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA. Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan, TX, USA.
Steven Nelson: Affiliation:
Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA. Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Ruth Lanius: Affiliation:
Department of Neuroscience, Western University, London, ON, Canada.
Jean Théberge: Affiliation:
Departments of Psychology and Psychiatry, Neuroscience Program, Western University, London, ON, Canada.
Maria Densmore: Affiliation:
Departments of Psychology and Psychiatry, Neuroscience Program, Western University, London, ON, Canada.
Richard Neufeld: Affiliation:
Departments of Psychology and Psychiatry, Neuroscience Program, Western University, London, ON, Canada.
Chadi Abdallah: Affiliation:
Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Christopher Averill: Affiliation:
Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.
Ilan Harpaz-Rotem: Affiliation:
Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA. Departments of Psychiatry and of Psychology, Wu Tsai Institute, Yale University, New Haven, CT, USA.
Ifat Levy: Affiliation:
Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA. Departments of Comparative Medicine, Neuroscience and Psychology, Wu Tsai Institute, Yale University, New Haven, CT, USA.
John Krystal: Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Division of Clinical Neuroscience, National Center for PTSD, West Haven, CT, USA.
Elbert Geuze: Affiliation:
Brain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands. University Medical Center, Utrecht, The Netherlands.
Remko van Lutterveld: Affiliation:
Brain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands. University Medical Center, Utrecht, The Netherlands.
Emily Dennis: Affiliation:
Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA. George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA. Department of Radiology, Stanford University, Stanford, CA, USA.
David Tate: Affiliation:
Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA. George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA.
David Cifu: Affiliation:
Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA.
William Walker: Affiliation:
Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA. Richmond VAMC, Central Virginia VA Health Care System, Richmond, VA, USA.
Elisabeth Wilde: Affiliation:
Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA. George E. Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, USA. H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Nic van der Wee: Affiliation:
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
Robert Vermeiren: Affiliation:
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Steven van der Werff: Affiliation:
Institute of Psychology, Clinical Psychology, Leiden University, Leiden, The Netherlands. Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands. Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
Katie McLaughlin: Affiliation:
Department of Psychology, Harvard University, Cambridge, MA, USA.
Kelly Sambrook: Affiliation:
Department of Radiology, University of Washington, Seattle, WA, USA.
Matthew Peverill: Affiliation:
Department of Psychology, University of Washington, Seattle, WA, USA.
Joaquim Radua: Affiliation:
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, University of Barcelona, Barcelona, Spain.
Lauren Salminen: Affiliation:
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Neda Jahanshad: Affiliation:
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Sophia Thomopoulos: Affiliation:
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Anthony James: Affiliation:
Department of Psychiatry, University of Oxford, Oxford, United Kingdom. Highfield Unit, Warneford Hospital, Oxford, United Kingdom.
Lucia Valmaggia: Affiliation:
Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia. Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom. Department of Psychiatry, KU Leuven, Leuven, Belgium.
Paul Thompson: Affiliation:
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Rajendra Morey: Affiliation:
Brain Imaging and Analysis Center, Duke University, Durham, NC, USA. Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.
Matthew Kempton: Affiliation:
Department of Psychosis, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom.
*: Corresponding Author: Cheryl See, Email: cheryl.see@kcl.ac.ukDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, 16 De Crespigny Park London SE5 8AB

Article contents

Abstract

Abstract

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Keywords

PTSD trauma voxel-based morphometry neuroimaging brain structure grey matter volume

Information

Type: Review/Meta-analysis
Information: European Psychiatry , Accepted manuscript , pp. 1 - 38

DOI: https://doi.org/10.1192/j.eurpsy.2025.10062 [Opens in a new window]
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