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The pharmacologic selectivity of serotonin reuptake inhibitors

Published online by Cambridge University Press:  16 April 2020

IF Tulloch
IF Tulloch*
Affiliation:
SmithKline Beecham Pharmaceuticals, Brentford, Middlesex, UK
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Summary

Paroxetine is a highly potent and selective inhibitor of serotonin reuptake, with in vitro potency greater than that of fluoxetine, fluvoxamine, and sertraline. It has little affinity for a wide variety of neurotransmitter receptors, including catecholaminergic or histaminergic systems, in marked contrast to the tricyclic antidepressants. Paroxetine undergoes first-pass metabolism that is partially saturable to give metabolites that are pharmacologically inactive in vivo, unlike those of fluoxetine or sertraline.

Keywords

paroxetineSSRItricyclicin vitroselectivity

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