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Long-term treatment of depression

Published online by Cambridge University Press:  16 April 2020

Y Lecrubier
Y Lecrubier*
Affiliation:
Hôpital de la Pitié-Salpêtrière, Pavillon Clérambault, 47, bd de l'Hôpital, 75013Paris, France
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Summary

Long-term treatment with antidepressants is now an accepted strategy in the management of depression. The demonstration of efficacy in this setting requires specific placebo-controlled trials of patients with recurrent depression studied after an adequate period of euthymia and for a long period of follow-up. This review examines the evidence for the prophylactic efficacy of antidepressant therapy with particular emphasis on the selective serotonin reuptake inhibitor, paroxetine.

Keywords

paroxetineSSRItricyclicmaprotilinephenelzinelong-termprophylaxis

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