Genome-wide methylation biomarkers and biological aging in patients with bipolar disorder characterized for lithium response

Claudia Pisanu*: Affiliation:
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
Alessandra Minelli: Affiliation:
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Donatella Congiu: Affiliation:
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
Anna Meloni: Affiliation:
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
Pasquale Paribello: Affiliation:
Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
Lisa Buson: Affiliation:
Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Caterina Chilllotti: Affiliation:
Unit of Clinical Pharmacology, University Hospital Agency of Cagliari, Cagliari, Italy
Marco Bortolomasi: Affiliation:
Psychiatric Hospital “Villa Santa Chiara”, Verona, Italy
Raffaella Ardau: Affiliation:
Unit of Clinical Pharmacology, University Hospital Agency of Cagliari, Cagliari, Italy
Massimo Gennarelli: Affiliation:
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Giovanni Severino: Affiliation:
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
Federica Pinna: Affiliation:
Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
Marco Pinna: Affiliation:
Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
Martina Contu: Affiliation:
Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
Maria Del Zompo: Affiliation:
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
Bernardo Carpiniello: Affiliation:
Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
Mirko Manchia: Affiliation:
Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy Department of Pharmacology, Dalhousie University, Halifax, NS, Canada
Alessio Squassina*: Affiliation:
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
*: Corresponding author:*Correspondence to: Alessio Squassina, Department of Biomedical Sciences, University of Cagliari, sp 8, 09042, Monserrato, Italy. E-mail: squassina@unica.it; Claudia Pisanu, Department of Biomedical Sciences, University of Cagliari, sp 8, 09042, Monserrato, Italy. E-mail: claudia.pisanu@unica.it
Corresponding author:*Correspondence to: Alessio Squassina, Department of Biomedical Sciences, University of Cagliari, sp 8, 09042, Monserrato, Italy. E-mail: squassina@unica.it; Claudia Pisanu, Department of Biomedical Sciences, University of Cagliari, sp 8, 09042, Monserrato, Italy. E-mail: claudia.pisanu@unica.it

Article contents

Abstract

Abstract

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Keywords

epigenetic age transcriptional age biomarkers precision psychiatry mood disorders

Information

Type: Research Article
Information: European Psychiatry , Accepted manuscript , pp. 1 - 31

DOI: https://doi.org/10.1192/j.eurpsy.2025.10112 [Opens in a new window]
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