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Depression in Patients with Chronic Heart Failure: Correlation with Hemodynamic Parameters and Lipids’ Metabolism

Published online by Cambridge University Press:  26 August 2025

S. Fedorov  and
A. K. Sikora
S. Fedorov
Affiliation:
Therapy and Family Medicine department of Post-graduate Faculty
A. K. Sikora*
Affiliation:
Psychiatry, Addictions and Medical Psychology Department, Ivano-Frankivsk National Medical University, Ivano-Frankivsk , Ukraine HOSPITAL OF THE MAZOWIECKIE VOIVODESHIP DREWNICA, Warsaw, Poland
*
*Corresponding author.

Abstract

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Introduction

Depression is a major concern in patients with chronic heart failure (CHF), with a prevalence of approximately 20-40%. It has been linked to worsened outcomes, including mortality and significant declines in physical and social functioning. Understanding the relationship between depression and hemodynamic as well as lipid metabolism parameters in CHF patients can provide insights into the underlying mechanisms of these worsened outcomes.

Objectives

This study aims to evaluate the correlation between depression and central hemodynamic and lipid metabolism parameters in patients with chronic heart failure (CHF).

Methods

The study involved 80 patients with CHF II-III NYHA classes caused by chronic coronary artery disease. They were divided into two groups: 20 without signs of depression and 60 with depression, as diagnosed using the Zung Self-Rating Depression Scale, Beck Depression Inventory, and Hamilton’s Depression Scale. Hemodynamic parameters were assessed using echocardiography (EchoCG), and lipid levels were measured in blood plasma. Statistical analyses were performed using t-tests, Mann–Whitney U tests, and correlation coefficients to determine relationships between variables.

Results

Depressive symptoms were prevalent in 71.6% of the CHF patients, with severe depression observed in 3.3%. Significant correlations were found between depression severity and blood pressure, triglyceride levels (r = 0.7, p < 0.05), and key echocardiographic measures such as left atrium diameter (r = 0.57, p < 0.05), end-diastolic size (r = 0.53, p < 0.05), and ejection fraction (r = -0.29, p < 0.05). Additionally, situational anxiety was significantly correlated with serum urea levels (r = 0.42, p < 0.05), triglycerides (r = 0.91, p < 0.05), and echocardiographic parameters.

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Conclusions

Patients with CHF and depression exhibit more severe central hemodynamic and lipid metabolism disorders than those without depression. These findings suggest that addressing depression in CHF management may mitigate some of the adverse effects on cardiovascular health.

Disclosure of Interest

None Declared

Information

Type
Abstract
Information
European Psychiatry , Volume 68 , Special Issue S1: Abstracts of the 33rd European Congress of Psychiatry , April 2025 , pp. S269
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of European Psychiatric Association
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