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Accepted manuscript

Clinical impact of obsessive-compulsive disorder comorbidity in bipolar disorder: a systematic review and meta-analysis

Published online by Cambridge University Press:  26 August 2025

Michele De Prisco Open the ORCID record for Michele De Prisco [Opens in a new window] ,
Cristiana Tapoi Open the ORCID record for Cristiana Tapoi [Opens in a new window] ,
Vincenzo Oliva Open the ORCID record for Vincenzo Oliva [Opens in a new window] ,
Robertas Strumila Open the ORCID record for Robertas Strumila [Opens in a new window] ,
Christine Takami Open the ORCID record for Christine Takami [Opens in a new window] ,
Nicolaja Girone Open the ORCID record for Nicolaja Girone [Opens in a new window] ,
Monica Macellaro Open the ORCID record for Monica Macellaro [Opens in a new window] ,
Juliana Braga de Salles Andrade Open the ORCID record for Juliana Braga de Salles Andrade [Opens in a new window] ,
Christian Nikolaus Schmitz Open the ORCID record for Christian Nikolaus Schmitz [Opens in a new window]  and
Eduard Vieta Open the ORCID record for Eduard Vieta [Opens in a new window]
...Show all authors
Michele De Prisco
Affiliation:
Institute of Neurosciences (ICN), Department of Medicine, Faculty of Medicine and Health Sciences, Universitat de Barcelona (UB), c. Casanova, 143, 08036 Barcelona, Spain. Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona. c. Villarroel, 170, 08036 Barcelona, Spain. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), c. Villarroel, 170, 08036 Barcelona, Spain. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Cristiana Tapoi
Affiliation:
Prof. Dr. Alexandru Obregia Clinical Psychiatry Hospital, Bucharest, Romania.
Vincenzo Oliva
Affiliation:
Institute of Neurosciences (ICN), Department of Medicine, Faculty of Medicine and Health Sciences, Universitat de Barcelona (UB), c. Casanova, 143, 08036 Barcelona, Spain. Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona. c. Villarroel, 170, 08036 Barcelona, Spain. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), c. Villarroel, 170, 08036 Barcelona, Spain. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Robertas Strumila
Affiliation:
Department of Urgent and Post Urgent Psychiatry, CHU Montpellier, 34000 Montpellier, France. Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France. Faculty of Medicine, Institute of Clinical Medicine, Psychiatric Clinic, Vilnius University, Vilnius, Lithuania.
Christine Takami
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Nicolaja Girone
Affiliation:
Department of Biomedical and Clinical Sciences “Luigi Sacco”, Department of Psychiatry, University of Milan, Milan, Italy.
Monica Macellaro
Affiliation:
Department of Biomedical and Clinical Sciences “Luigi Sacco”, Department of Psychiatry, University of Milan, Milan, Italy.
Juliana Braga de Salles Andrade
Affiliation:
D'Or Institute for Research and Education - IDOR, Rio de Janeiro, Brazil.
Christian Nikolaus Schmitz
Affiliation:
Department of Molecular Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. German Center for Mental Health (DZPG), partner site Mannheim.
Eduard Vieta*
Affiliation:
Institute of Neurosciences (ICN), Department of Medicine, Faculty of Medicine and Health Sciences, Universitat de Barcelona (UB), c. Casanova, 143, 08036 Barcelona, Spain. Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona. c. Villarroel, 170, 08036 Barcelona, Spain. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), c. Villarroel, 170, 08036 Barcelona, Spain. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Giovanna Fico
Affiliation:
Institute of Neurosciences (ICN), Department of Medicine, Faculty of Medicine and Health Sciences, Universitat de Barcelona (UB), c. Casanova, 143, 08036 Barcelona, Spain. Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona. c. Villarroel, 170, 08036 Barcelona, Spain. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), c. Villarroel, 170, 08036 Barcelona, Spain.
*
*Corresponding Author Prof. Eduard Vieta, MD, PhD Bipolar and Depressive Disorders Unit, Institute of Neuroscience IDIBAPS CIBERSAM Hospital Clinic, University of Barcelona, 170 Villarroel St 12-0, 08036 Barcelona, Catalonia, Spain. Email: evieta@clinic.cat

Abstract

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Keywords

Bipolar disorderobsessive-compulsive disordercomorbiditysuicidemeta-analysis

Information

Type
Review/Meta-analysis
Information
European Psychiatry , Accepted manuscript , pp. 1 - 34
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of European Psychiatric Association

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The authors contributed equally

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