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The association between oxytocin receptor gene polymorphism, childhood adversity and negative symptoms of schizophrenia

Published online by Cambridge University Press:  26 August 2025

T. Lezheiko ,
V. Golimbet ,
V. Mikhailova  and
M. Gabaeva
T. Lezheiko
Affiliation:
Clinical Genetics Laboratory, Mental Health Research Center, Moscow, Russian Federation
V. Golimbet*
Affiliation:
Clinical Genetics Laboratory, Mental Health Research Center, Moscow, Russian Federation
V. Mikhailova
Affiliation:
Clinical Genetics Laboratory, Mental Health Research Center, Moscow, Russian Federation
M. Gabaeva
Affiliation:
Clinical Genetics Laboratory, Mental Health Research Center, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Neurohormone oxytocin plays an important role in the pathogenesis of mental illness, and also moderates the relationship between stress factors, especially those acting in the early stages of development, and the development of mental disorders. Literature data indicate that environmental risk factors significantly increase the risk of schizophrenia and the severity of its clinical presentation.

Objectives

To study the association between the oxytocin receptor (OXTR) rs468302 and rs7632287 polymorphisms and negative symptoms of schizophrenia, taking into childhood adversity (CA), i.e. events that could adversely affect the psychoemotional state and development of the child in the period up to 18 years. CA includes abuse in the family, alcohol or drug addiction in parents, mental disorders.

Methods

The study included 592 patients with schizophrenia (items F20. according to ICD-10). Information about the presence of CA was obtained from case histories and patient interviews. Analysis of covariance was used for statistical data processing; in post-hoc pairwise comparison, Tukey’s test was used.

Results

A significant effect of the interaction between CA and OXTR gene polymorphism rs7632287(G\A) on the severity of negative symptoms in patients with schizophrenia was revealed. For rs4686302 (C\T) polymorphism the association was found at the trend level. In patients without CA, polymorphisms did not have a significant effect.

Conclusions

The OXTR rs468302 and rs7632287 polymorphisms, previously associated with phenotypes related to social behavior, may be associated with negative symptoms of schizophrenia, and the association is mediated by the presence of a history of psychotraumatic events acting at an early stage of development.

Disclosure of Interest

None Declared

Information

Type
Abstract
Information
European Psychiatry , Volume 68 , Special Issue S1: Abstracts of the 33rd European Congress of Psychiatry , April 2025 , pp. S754 - S755
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of European Psychiatric Association
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