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Adrenal gland volume measurement in depressed patients

Published online by Cambridge University Press:  26 August 2025

L. Stepansky ,
R. Ruppel ,
L. Sommerfeld ,
J. Kleiß ,
K. Türkan ,
S. Arndt ,
S. Bickelhaupt ,
F. Knoll ,
M. Uder  and
M. May
L. Stepansky*
Affiliation:
Institute of Radiology, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen
R. Ruppel
Affiliation:
Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin
L. Sommerfeld
Affiliation:
Institute of Radiology, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen
J. Kleiß
Affiliation:
Institute of Radiology, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen
K. Türkan
Affiliation:
Institute of Radiology, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen
S. Arndt
Affiliation:
Institute of Radiology, University Hospital Erlangen Medical Centre for Information and Communication Technology, University Hospital Erlangen
S. Bickelhaupt
Affiliation:
Institute of Radiology, University Hospital Erlangen
F. Knoll
Affiliation:
Department Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-University Erlangen-Nürnberg
M. Uder
Affiliation:
Institute of Radiology, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen Imaging Science Institute, University Hospital Erlangen, Erlangen, Germany
M. May
Affiliation:
Institute of Radiology, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen Imaging Science Institute, University Hospital Erlangen, Erlangen, Germany
*
*Corresponding author.

Abstract

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Introduction

Prior studies have shown contradicting results regarding adrenal gland volume (AGV) in depressed patients, with some reporting significant enlargement and others not.

Objectives

The aim of this study was to retrospectively compare CT image segmentations of the adrenal glands in patients with depression to a control group with stringent exclusion criteria to minimize confounding factors.

Methods

We included patients diagnosed with depression (ICD-10: F32/33) who underwent abdominal CT imaging between 2012 and 2022 and did not have any other psychiatric disorders. Diagnoses that could potentially influence AGV were excluded. The resulting 31 depressed patients were compared to a matching control group of 31 patients without depression. The AGV was manually segmented in thin-sliced reconstructions (≤1 mm).

Results

Total AGV in the depressed group was 6.78 (5.19-7.56) cm3 compared to 6.90 (5.54-10.05) cm3 in the control group. There was no significant difference in AGV between the two groups after adjusting for age, height, and weight. A positive correlation was observed between AGV and height (r=0.41, p<0.001) and weight (r=0.52, p<0.001). Males showed significantly larger AGV than females (p≤0.001), and left AGV was significantly larger than right AGV (p<0.001). Patients within the depressed group who underwent imaging after a suicide attempt showed larger total AGV compared to the control group, though not statistically significant.

Conclusions

AGV is not increased in the well-selected cohort of depressed patients in this study, which contrasts with some previous reports in literature. Further multi-centric studies are required to identify potentially influencing factors such as attempted suicide.

Disclosure of Interest

None Declared

Information

Type
Abstract
Information
European Psychiatry , Volume 68 , Special Issue S1: Abstracts of the 33rd European Congress of Psychiatry , April 2025 , pp. S282
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of European Psychiatric Association
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