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Treatment of severe depression with paroxetine

Published online by Cambridge University Press:  16 April 2020

J Tignol
J Tignol*
Affiliation:
Université de Bordeaux II, 121, rue de la Béchade, 33076Bordeaux, France
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Summary

Meta-analyses of 417 patients diagnosed either prospectively (316 US patients) or retrospectively (101 European patients) as suffering from melancholia according to DSM III criteria have shown that paroxetine was significantly better than placebo with respect to all outcome measures. There was no significant difference between active control and placebo in these analyses. In a group of 216 severely depressed hospitalised patients with a HAMD score of 25 or more, paroxetine was as effective as active control.

Keywords

paroxetinemelancholiaHamilton Depression Rating Scale

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References

Dunbar, GCStoker, MJ (1991) Paroxetine in the treatment of severe (melancholic) depression. Paper presented at the 5th World Cong Biol Psychiatry, June 9–14Google Scholar
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