Hostname: page-component-cb9f654ff-fg9bn Total loading time: 0 Render date: 2025-08-26T16:26:26.048Z Has data issue: false hasContentIssue false
  • English
  • Français

The effects of antidepressant treatment on sleep disturbances in depression

Published online by Cambridge University Press:  16 April 2020

M Kerkhofs  and
J Mendlewicz
M Kerkhofs
Affiliation:
Sleep laboratory, Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Route de Lennik 808, 1070Brussels, Belgium
J Mendlewicz
Affiliation:
Sleep laboratory, Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Route de Lennik 808, 1070Brussels, Belgium
Get access

Summary

Sleep problems are classical complaints in depressed patients. Polygraphie recordings performed in drug free depressed patients during an acute episode of the illness have allowed description of sleep continuity, architecture and REM sleep disturbances. While the specificity of these abnormalities is not fully established, these perturbations appear to be core symptoms of the depressive episode. Antidepressants drugs, whatever their pharmacological profile have been shown to suppress or at least to reduce REM sleep. However, the effects of these drugs on sleep continuity and architecture seem to be related to their specific pharmacological action.

Keywords

REM sleepnon-REM sleeptricyclicsMAOIsSSRIs

Information

Type
Original article
Information
European Psychiatry , Volume 10 , Issue 8 , 1995 , pp. 391 - 396
Copyright
Copyright © Elsevier, Paris 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Akindele, MOEvrans, JIOswald, IMonoamine oxidase inhibitors, sleep and mood. Electroencephalog Clin Neurophysiol 1970; 29: 47–56CrossRefGoogle Scholar
Baxter, BLGluckman, MIIprindole: an antidepressant which does not block REM sleep Nature 1969; 223: 750–2CrossRefGoogle Scholar
Benca, RMObermeyer, WHThisted, RAGillin, JSleep, psychiatric disorders. A meta-analysis. Arch gen Psychiatry 1992; 49: 651–68CrossRefGoogle ScholarPubMed
Blackburn, ABKaracan, ISalis, PJOkawa, MAnch, AMWilliams, RLThe effects of doxepin hcl on sleep patterns of neurotically depressed patients with sleep disturbance Sleep Res 1975; 4: 90Google Scholar
Borbély, AAWirz-Justice, ASleep, sleep deprivation and depression. Human Neurobiol 1982; 1: 250–10Google ScholarPubMed
Chen, CNSleep, depression and antidepressants. Br J Psychiatry 1979; 135: 385–402CrossRefGoogle ScholarPubMed
Coble, PAFoster, FGKupfer, DJElectroencephalographic sleep diagnosis of primary depression. Arch Gen Psychiatry 1976; 33: 1124–7Google ScholarPubMed
Detre, THimmelhoch, JSwartzburg, MAnderson, CMByck, RKupfer, DJHypersomnia and manic-depressive disease Am J Psychiatry 1972; 128: 1303–5CrossRefGoogle ScholarPubMed
Dube, SJones, DABell, JDavies, ARoss, ESitaram, NInterface of panic and depression: clinical and sleep EEG correlates. Psychiatry Res 1986; 19: 119–33CrossRefGoogle ScholarPubMed
Feinberg, IBraun, MKoresko, RLGottlieb, FStage 4 sleep in schizophrenia. Arch Gen Psychiatry 1969; 21: 262–6CrossRefGoogle Scholar
Feinberg, MGillin, JCCarrol, BJGreden, JFZis, APEEG studies of sleep in the diagnosis of depression Biol Psychiatry 1982; 17: 305–16Google ScholarPubMed
Feuillade, PPringuey, DBelugou, JLRobert, PHarcourt, GTrimipramine: acute and lasting effects on sleep in healthy and major depressive subjects. J Affect Disord 1992; 24: 135–46CrossRefGoogle ScholarPubMed
Ganguli, RReynolds, CF IIIKupfer, DJElectroencephalographic sleep in young never-medicated schizophrenics Arch Gen Psychiatry 1987; 44: 36–44CrossRefGoogle ScholarPubMed
Gilles, DEJarrett, RBRoffwarg, HPRush, AJReduced rapid eye movement latency. A predictor of recurrence in depression. Neuropsychopharmacology 1987; 1: 33–9CrossRefGoogle Scholar
Gillin, JCWyatt, RJFram, DSnyder, FThe relationship between changes in REM sleep and clinical improvement in depressed patients related with amitriptyline. Psychopharmacology 1978; 59: 267–72CrossRefGoogle Scholar
Gillin, JCDuncan, WCPettigrew, KDFrankel, BLSnyder, FSuccessful separation of depressed, normal and insomniac subjects by EEG sleep data. Arch Gen Psychiatry 1979; 36: 85–90CrossRefGoogle ScholarPubMed
Gillin, JCDuncan, WBMurphy, DL, et al. Age related changes in sleep in depressed and normal subjects. Psychiatry Res 1981; 4: 73–8CrossRefGoogle ScholarPubMed
Gillin, JCThe sleep therapies of depression. Prog Neuropsychopharmacol Biol Psychiatry 1983; 7: 351–64CrossRefGoogle ScholarPubMed
Hawkins, DRTaub, JMVan De Castle, RLExtended sleep (hypersomnia) in young depressed patients. Am J Psychiatry 1985; 142: 905–10Google Scholar
Hiatt, JFFlyod, TCKatz, PHFeinberg, IFurther evidence of abnormal non-rapid-eye-movement sleep in schizophrenia. Arch Gen Psychiatry 1985; 42: 797–802CrossRefGoogle Scholar
Hochli, DRiemman, DZulley, JBerger, MInitial REM suppression by clomipramine; a pronostic tool for treatment response in patients with a major depressive disorder. Biol Psychiatry 1986; 21: 1217–20CrossRefGoogle Scholar
Insel, TRGillin, JCMoore, AMendelson, WBLoewenstein, RJMurphy, DLThe sleep of patients with obsessive-compulsive disorder. Arch Gen Psychiatry 1982; 39: 1372–7CrossRefGoogle ScholarPubMed
Kempenaers, CKerkhofs, MLinkowski, PMendlewicz, JSleep EEG variables in young schizophrenic and depressive patients. Biol Psychiatry 1988; 24: 828–33CrossRefGoogle ScholarPubMed
Kerkhofs, MKempenaers, CLinkowski, PDe Maertelaer, VMendlewicz, JMultivariate study of sleep EEG in depression. Acta Psychiatr Scand 1988; 77: 463–8CrossRefGoogle ScholarPubMed
Kerkhofs, MRielaert, CDe Maertelaer, VLinkowski, PCzarka, MMendlewicz, JFluoxetine in major depression: efficacy, safety and effects on sleep polygraphic variables Intern Clin Psychopharmacol 1990; 5: 253–60CrossRefGoogle ScholarPubMed
Kerkhofs, MLinkowski, PLucas, FMendlewicz, JTwenty-fourhour patterns of sleep in depression. Sleep 1991; 14: 501–6CrossRefGoogle Scholar
Klein, EHefez, ALavie, PEffects of clomipramine infusion on sleep in depressed patients. Neuropsychobiology 1984; 1: 85–8CrossRefGoogle Scholar
Kupfer, DJREM latency: a psychobiologic marker of primary depressive disease. Biol Psychiatry 1976; 11: 159–74Google ScholarPubMed
Kupfer, DJFoster, GCoble, Pmc Partland, RJUlrich, RFThe application of EEG sleep for the differential diagnosis of affective disorders. Am J Psychiatry 1978a; 135: 69–74Google ScholarPubMed
Kupfer, DJSpiker, DJCoble, Pmc Partland, RJAmitriptyline, EEG sleep in depressed patients: I. drug effect. Sleep 1978; 1: 149–59Google ScholarPubMed
Kupfer, DJCoble, PKane, JPetti, TConners, KImipramine and EEG sleep in children with depressive symptoms. Psychopharmacology 1979; 60: 117–23CrossRefGoogle ScholarPubMed
Kupfer, DJSpiker, DJRossi, ACoble, PAShaw, DUlrich, RNortriptyline and EEG sleep in depressed patients. Biol Psychiatry 1982a; 7: 535–46Google Scholar
Kupfer, DJHanin, ICoble, PASpiker, DGSorisio, DGrau, TGEEG sleep and tricyclic blood levels: acute and chronic administration in depression. J Clin Psychopharmacol 1982b; 2: 8–13CrossRefGoogle ScholarPubMed
Kupfer, DJEhlers, CLPollock, BGNathan, SPerel, JMClomipramine and sleep EEG in depression. Psychiatry Res 1989; 30: 165–80CrossRefGoogle ScholarPubMed
Kupfer, DJPerel, JMPollock, BG, et al.Fluvoxamine versus desipramine: comparative polysomnographic effects. Biol Psychiatry 1991; 29: 23–40CrossRefGoogle ScholarPubMed
Mc Carley, RWSleep and depression: common neurobiological control mechanisms. Am J Psychiatry 1982; 139: 565–70Google Scholar
Mendlewicz, JDunbar, GCHoffmann, GChanges in sleep EEG architecture during the treatment of depressed patients with mianserin. Acta Psychiatr Scand 1985 72 (suppl 320): 26–9CrossRefGoogle Scholar
Mendlewicz, JKempenaers, Cde Maertelaer, VSleep EEG and amitriptyline treatment in depressed inpatients. Biol Psychiatry 1991a; 30: 691–702Google ScholarPubMed
Mendlewicz, JKerkhofs, MSleep EEG in depressive illness: a World Health Organization collaborative study. Br J Psychiatry 1991b; 159: 505–9CrossRefGoogle Scholar
Monti, JMAlterwain, PMonti, DThe effects of moclobemide on nocturnal sleep of depressed patients. J Affect Disord 1990; 20: 201–8CrossRefGoogle ScholarPubMed
Mouret, JLemoine, PMinuit, MPBenkelfat, CRenardet, MEffects of trazodone on the sleep of depressed subjects: a polygraphic study. Psychopharmacology 1988; 95: S37–S43CrossRefGoogle ScholarPubMed
Nicholson, ANPascoe, PARapide eye movement sleep and sleep continuity. Depres Antidepres Drugs 1989; (suppl 1) 4–13Google Scholar
Papadimitriou, GNKerkhofs, MKempenaers, CMendlewicz, JEEG sleep studies in patients with generalized anxiety disorder. Psychiatry Res 1988; 26: 183–90CrossRefGoogle ScholarPubMed
Reynolds, ChF IIIShax, DHNewton, TFCoble, PAKupfer, DJEEG sleep in outpatients with generalized anxiety: a preliminary comparison with depressed outpatients. Psychiatry Res 1983; 8: 81–9CrossRefGoogle ScholarPubMed
Reynolds, CF IIIKupfer, DJSleep research in affective illness: state of the art circa 1987. Sleep 1987; 10: 199–215CrossRefGoogle ScholarPubMed
Roth, TZorick, FWittig, RMc Lenaghan, ARoehs, TThe effects of doxepin HCL on sleep and depression. J Clin Psychiatry 1982; 43: 366–8Google ScholarPubMed
Schenk, CHMahowald, MWKim, SWO'Connor, KAHurwitz, TDProminent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder. Sleep 1992; 15: 226–35CrossRefGoogle Scholar
Schulz, HLund, ROn origin of early REM episodes in the sleep of depressed patients: a comparison of three hypothesis. 1985; 16: 65–77Google Scholar
Shipley, JEKupfer, DJGriffin, SJ, et al. Comparison of the effects of desipramine and amitriptyline on EEG sleep of depressed patients. Psychopharmacology 1985; 85: 14–22CrossRefGoogle ScholarPubMed
Spiker, DGGrau, TNeil, JFCoble, PFoster, FGKupfer, DJEffect of amitriptyline vs nostriptyline on sleep of depressed patients. Sleep Res 1978; 7: 205Google Scholar
Staner, LKerkhofs, MDetroux, D, et al. A double-blind comparison of the effects of paroxetine and amitriptyline on sleep EEG in patients with major depression. J Sleep Res 1992; 1: 218Google Scholar
Thase, MEKupfer, DJSpiker, DGElectroencephalographic sleep in secondary depression: a revisit. Biol Psychiatry 1984; 19: 805–10Google ScholarPubMed
Thase, MEKupfer, DJElectroencephalographic sleep in psychotic depression. A valid subtype? Arch Gen Psychiatry 1986; 43: 886–93CrossRefGoogle ScholarPubMed
Uhde, TWRoy-Byrne, PGillin, JC, et al. The sleep of patients with panic disorder. A preliminary report. Psychiatry Res 1984; 12: 251–9CrossRefGoogle ScholarPubMed
Ulrich, RFShaw, DHKupfer, DJEffects of aging on EEG sleep in depression. Sleep 1980; 3: 31–40Google ScholarPubMed
van Bemmel, ALHavermans, RGvan Diest, REffects of trazodone on EEG sleep and clinical state in major depression. Psychopharmacology 1992; 107: 569–74CrossRefGoogle Scholar
Vogel, GWBuffenstein, AMinter, KHennesey, ADrug effects on REM sleep and on endogenous depression. Neurosc Biobehav Rev 1990; 14: 49–63CrossRefGoogle ScholarPubMed
Ware, JCBrown, FWMoorad, PJPittard, JTCobert, BEffects on sleep: a double-blind study comparing trimipramine to imipramine in depressed insomnia patients. Sleep 1989; 12: 537–49CrossRefGoogle Scholar
Wehr, TAWirz-Justice, AGoodwin, FKDuncan, WGillin, JCPhase advance of the sleep-wake cycle as an antidepressant. Science 1979; 206: 710–13CrossRefGoogle ScholarPubMed
Wyatt, RJFram, DHKupfer, DJSnyder, FTotal prolonged drug-induced REM suppression in anxious-depressed patients. Arch Gen Psychiat 1971; 24: 145–55CrossRefGoogle ScholarPubMed
Zarcone, VCBenson, KLBerger, PAAbnormal rapide eye movement latencies in schizophrenia. 1987; 44: 45–8Google Scholar
Submit a response

Comments

No Comments have been published for this article.