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Fluid therapy in sepsis with capillary leakage

Published online by Cambridge University Press:  11 July 2005

G. Marx
G. Marx
Affiliation:
University of Liverpool, University Department of Anaesthesia, Liverpool, UK
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Summary

Sepsis is associated with a profound intravascular fluid deficit due to vasodilatation, venous pooling and capillary leakage. Fluid therapy is aimed at restoration of intravascular volume status, haemodynamic stability and organ perfusion. Circulatory stability following fluid resuscitation is usually achieved in the septic patient at the expense of tissue oedema formation that may significantly influence vital organ function. The type of fluid therapy, crystalloid or colloid, in sepsis with capillary leakage remains an area of intensive and controversial discussion. The current understanding of the physiology of increased microvascular permeability in health and sepsis is incomplete. Furthermore, there is a lack of appropriate clinical study end-points for fluid resuscitation. This review considers critically the clinical and experimental data analysing the assessment of capillary leakage in sepsis and investigating the effects of different fluid types on increased microvascular permeability in sepsis.

Keywords

FLUID THERAPYINFECTION, sepsis, septic, septicaemia, shockVASCULAR DISEASES, capillary leak syndrome

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Type
Review
Information
European Journal of Anaesthesiology , Volume 20 , Issue 6 , June 2003 , pp. 429 - 442
Copyright
© 2003 European Society of Anaesthesiology

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