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Clonal dissemination of two MRSA strains in Germany

Published online by Cambridge University Press:  15 May 2009

W. Witte ,
C. Cuny ,
C. Braulke  and
D. Heuck
W. Witte
Affiliation:
Robert Koch-Institute, Wernigerode Branch, Burgstraβe 37, D-38855 Wernigerode, Germany
C. Cuny
Affiliation:
Robert Koch-Institute, Wernigerode Branch, Burgstraβe 37, D-38855 Wernigerode, Germany
C. Braulke
Affiliation:
Robert Koch-Institute, Wernigerode Branch, Burgstraβe 37, D-38855 Wernigerode, Germany
D. Heuck
Affiliation:
Robert Koch-Institute, Wernigerode Branch, Burgstraβe 37, D-38855 Wernigerode, Germany
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Summary

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Clonal dissemination of two different MRSA strains, both clumping factor negative, has been observed in Germany for more than a year. Both strains possess the mec-A determinant and each exhibits a characteristic genomic DNA fragment pattern. One strain has spread in the north, the other in the south-west of Germany.

Intensive care units are mainly affected by MRSA-infections and probably play a special role in further intra- and inter-hospital spread.

Information

Type
Research Article
Information
Epidemiology & Infection , Volume 113 , Issue 1 , August 1994 , pp. 67 - 73
Copyright
Copyright © Cambridge University Press 1994

References

REFERENCES

1.Voss, A, Machka, K, Lenz, W, Milatovic, D. Vorkommen, H¨aufigkeit und Resistenzverhalten von Methicillin-Oxacillin-resistenten Staphylococcus aureus-Stämmen in Deutschland. Dtsch med Wschr 1992; 117: 1007–12.CrossRefGoogle Scholar
2.Witte, W, Braulke, C, Cuny, Ch. Mehrfachresistente Staphylokokken, Auftreten und Verbreitung. Chemother J 1992; 1: 17–23.Google Scholar
3.Hartman, BI, Tomasz, A. Low affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J Bacteriol 1984; 18: 513–16.CrossRefGoogle Scholar
4.Kreiswirth, B, Kornblum, JU, Arbeit, RD et al. , Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus. Science 1989; 259: 227–30.CrossRefGoogle Scholar
5.Witte, W, Richardson, JF, Marples, RR. Complex typing of methicillin resistant Staphylococcus aureus (MRSA). Zbl Bakt Hyg 1988; A268: 76–82.Google Scholar
6.Prevost, G, Jaulhac, B, Piemont, J. DNA fingerprinting by pulsed field gel electrophoresis is more effective than ribotyping in distinguishing among methicillin resistant Staphylococcus aureus isolates. J Clin Microbiol 1992; 30: 967–73.CrossRefGoogle ScholarPubMed
7.Goering, RV, Duensing, TD. Rapid field inversion gel electrophoresis in combination with an rRNA gene probe in the epidemiological evaluation of staphylococci. J Clin Microbiol 1991: 28: 426–9.CrossRefGoogle Scholar
8.Witte, W, Cuny, Ch, Claus, H. Clonal relatedness of Staphylococcus aureus strains from infections in humans as deduced from genomic DNA fragment patterns. Med Microbiol Lett 1993; 2: 72–9.Google Scholar
9.Marples, RR, Cooke, EM. Current problems with methicillin resistant Staphylococcus aureus. J Hosp Infect 1988; 11: 381–2.CrossRefGoogle ScholarPubMed
10.Jordens, JZ, Hall, LMC. Molecular epidemiology of methicillin-resistant Staphylococcus aureus. Zbl Bakt Suppl 1991; 21: 371–2.Google Scholar
11.Melo-Christino, JAG, Torres, Pereira A, Afonso, F, Naidoo, J. Methicillin resistant Staphylococcus aureus: a 6 month survey in a Lisbon pediatric hospital. J Hyg 1986: 97: 265–72.CrossRefGoogle Scholar
12.Aparicio, P, Richardson, J, Martin, S. Vindel, A, Marples, RR, Cookson, B. An epidemic methicillin-resistant strain of Staphylococcus aureus in Spain. Epidemiol Infect 1992; 108: 287–98.CrossRefGoogle ScholarPubMed
13.Witte, W. Cuny, Ch. Claus, H. Unrelatedness of multiply resistant Staphylococcus aureus with resistance to methicillin and to quinolones (QR-MRSA) as evident from Sma I-digestion patterns of genomic DXA. Zbl Bakt 1993: 278: 510–17.CrossRefGoogle Scholar
14.Witte, W, Grimm, H. Occurrence of quinolone resistance in S. aureus from nosocomial infections. Epidemiol Infect 1992; 109: 413–21.CrossRefGoogle Scholar
15. Deutsches Institut für Normung e.V. Methoden zur Empfinlichkeitsprüfung von Krankheitserregern gegen Chemotherapeutika. Beuth Verlag Berlin 1990; Mikrodilution DIN 58940. Teil 8.Google Scholar
16.Witte, W, Braulke, C, Wicke, G, Halle, E. Nachweis des Verklumpungsfaktors mit stabilisiertemFibrinogen für die schnelle Diagnostik von Staphylococcus aureus. Z Klin Med 1988; 43: 1333–5.Google Scholar
17.Witte, W. Hummel, R. Meyer, W, Exner, H, Wundrak, R. Ecology of Staphylococcus aureus: characterization of strains from chickens. Z Allg Mikrobiol 1977; 639–46.Google Scholar
18.Monzon-Moreno, C, Aubert, S, Morvan, A, El Soh, N. Usefulness of three probes in typing isolates of methicillin-resistant Staphylococcus aureus (MRSA). J Med Microbiol 1991; 3: 80–8.CrossRefGoogle Scholar
19.Bitar, CM. Mayhall, CG, Lamb, VA, Bradshaw, TJ, Spadora, AC, Dalton, HP. Outbreak due to methicillin- and rifampicin-resistant Staphylococcus aureus: epidemiology and eradication of the resistant strain from the hospital. Infect Control 1987; 8: 15–23.CrossRefGoogle Scholar
20.Peacock, JE Jr. Marsik, FJ, Wenzel, RP. Methicillin resistant Staphylococcus aureus: introduction and spread within a hospital. Ann Intern Med 1980; 93: 526–32.CrossRefGoogle ScholarPubMed
21.Casewell, MW, Hill, RLR. In-vitro activity of mupirocin (pseudomonic acid) against clinical isolates of Staphylococcus aureus. J Antimicrob Chemother 1985; 15: 523–31.CrossRefGoogle ScholarPubMed
22.Mulligan, M. Murray-Leisure, KA, Ribner, BS et al. Methicillin-resistant Staphylococcus aureus: a consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management. Am J Med 1993; 94: 313–28.CrossRefGoogle ScholarPubMed
23.Cuny, Ch, Schassan, HH, Witte, W. Outbreak of nosocomial infections with two different MRSA-strains involved: significance of genomic DNA fragment patterns in strains otherwise difficult to type. Epidemiol Infect 1993; 111: 55–61.CrossRefGoogle ScholarPubMed
24.Schwarzkopf, A, Karch, H, Schmidt, H, Lenz, W, Heesemann, J. Phenotypical and genotypical characterization of epidemic clumping factor negative, oxacillin-resistant Staphylococcus aureus. J Clin Microbiol 1993; 31: 2281–5.CrossRefGoogle ScholarPubMed